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Expression of ecalectin, a novel eosinophil chemoattractant, in nasal polyps.

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Title: Expression of ecalectin, a novel eosinophil chemoattractant, in nasal polyps.
Authors: Iino, Y. (AUTHOR), Miyazawa, T. (AUTHOR), Kakizaki, K. (AUTHOR), Saigusa, H. (AUTHOR), Katano, H. (AUTHOR), Shiga, J. (AUTHOR), Kanegasaki, S. (AUTHOR)
Source: Acta Oto-Laryngologica. Jan2006, Vol. 126 Issue 1, p43-50. 8p. 3 Diagrams, 2 Charts, 2 Graphs.
Subjects: Nasal polyps, Eosinophils, Eosinophil disorders, Nasal cavity, Paranasal sinuses, Case studies, Diseases
Abstract: Conclusion. Ecalectin, which is produced in the mucosa of nasal polyps, seems to play an important role in the accumulation and activation of eosinophils in nasal polyps, regardless of the presence or absence of atopic predisposition. Objective . Ecalectin is a recently discovered eosinophil chemoattractant which belongs to the galectin family. We investigated the expression of ecalectin in nasal polyp tissues associated with various nasal and paranasal diseases in order to clarify the pathogenesis of eosinophilia in nasal polyposis. Material and methods . Nasal polyps were taken from 56 patients diagnosed as having chronic sinusitis with nasal polyposis. The surgically resected polyps and nasal turbinates were immunohistochemically stained using antibodies against EG2, human mast cell tryptase, CD3 and ecalectin. Results . The number of EG2- and ecalectin-positive cells was significantly higher in nasal polyps than control turbinates. Ecalectin-positive cells were observed in the subepithelial layer, where many EG2-positive cells were present. The number of ecalectin-positive cells correlated significantly with the number of EG2-positive cells in nasal polyps. Many ecalectin mRNA-positive cells were also observed in nasal polyps with an accumulation of EG2-positive cells. [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Expression of ecalectin, a novel eosinophil chemoattractant, in nasal polyps.
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  Data: <searchLink fieldCode="AR" term="%22Iino%2C+Y%2E%22">Iino, Y.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miyazawa%2C+T%2E%22">Miyazawa, T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kakizaki%2C+K%2E%22">Kakizaki, K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Saigusa%2C+H%2E%22">Saigusa, H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Katano%2C+H%2E%22">Katano, H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shiga%2C+J%2E%22">Shiga, J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kanegasaki%2C+S%2E%22">Kanegasaki, S.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Jan2006, Vol. 126 Issue 1, p43-50. 8p. 3 Diagrams, 2 Charts, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Nasal+polyps%22">Nasal polyps</searchLink><br /><searchLink fieldCode="DE" term="%22Eosinophils%22">Eosinophils</searchLink><br /><searchLink fieldCode="DE" term="%22Eosinophil+disorders%22">Eosinophil disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Nasal+cavity%22">Nasal cavity</searchLink><br /><searchLink fieldCode="DE" term="%22Paranasal+sinuses%22">Paranasal sinuses</searchLink><br /><searchLink fieldCode="DE" term="%22Case+studies%22">Case studies</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases%22">Diseases</searchLink>
– Name: Abstract
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  Data: Conclusion. Ecalectin, which is produced in the mucosa of nasal polyps, seems to play an important role in the accumulation and activation of eosinophils in nasal polyps, regardless of the presence or absence of atopic predisposition. Objective . Ecalectin is a recently discovered eosinophil chemoattractant which belongs to the galectin family. We investigated the expression of ecalectin in nasal polyp tissues associated with various nasal and paranasal diseases in order to clarify the pathogenesis of eosinophilia in nasal polyposis. Material and methods . Nasal polyps were taken from 56 patients diagnosed as having chronic sinusitis with nasal polyposis. The surgically resected polyps and nasal turbinates were immunohistochemically stained using antibodies against EG2, human mast cell tryptase, CD3 and ecalectin. Results . The number of EG2- and ecalectin-positive cells was significantly higher in nasal polyps than control turbinates. Ecalectin-positive cells were observed in the subepithelial layer, where many EG2-positive cells were present. The number of ecalectin-positive cells correlated significantly with the number of EG2-positive cells in nasal polyps. Many ecalectin mRNA-positive cells were also observed in nasal polyps with an accumulation of EG2-positive cells. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Eosinophil disorders
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      – SubjectFull: Nasal cavity
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      – TitleFull: Expression of ecalectin, a novel eosinophil chemoattractant, in nasal polyps.
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              Text: Jan2006
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