Statins and Their Effect on Hearing: An All of Us Database Study.
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| Title: | Statins and Their Effect on Hearing: An All of Us Database Study. |
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| Authors: | Homer, Benjamin J. (AUTHOR), Kasthuri, Viknesh S. (AUTHOR), Jain, Rishubh (AUTHOR), Homer, Alexander S. (AUTHOR), Gjini, Emily (AUTHOR), Noonan, Kathryn Y. (AUTHOR) |
| Source: | Annals of Otology, Rhinology & Laryngology. Jan2026, Vol. 135 Issue 1, p20-26. 7p. |
| Subjects: | Drug therapy for hyperlipidemia, Databases, Medical information storage & retrieval systems, Simvastatin, Risk assessment, Mitochondria, Research funding, Sensorineural hearing loss, Logistic regression analysis, Aspirin, Hypertension, Sex distribution, Fluvastatin, Population health, Retrospective studies, Age distribution, Multivariate analysis, Descriptive statistics, Tinnitus, Odds ratio, Race, Atorvastatin, Surveys, Statins (Cardiovascular agents), Medical records, Acquisition of data, Electronic health records, Hearing, Hearing disorders, Ototoxicity, Confidence intervals, Data analysis software, Diabetes, Disease risk factors |
| Geographic Terms: | United States |
| Abstract: | Objective: Hearing loss affects approximately 23% of Americans and is associated with medical comorbidities including hyperlipidemia. Statins, commonly used for dyslipidemia, may protect against hearing loss in animal models, but human studies show mixed results. This study aims to investigate statins and their effect on hearing loss and tinnitus. Methods: This study is a retrospective cohort study using the All of Us database. All of Us is a NIH-funded research database representing more than 710,000 participants in the United States. Patients with hyperlipidemia were labeled based on their exposure to at least 1 statin and additionally labeled for diagnoses of sensorineural hearing loss and/or tinnitus. Logistic regressions were performed with independent variables of statin use, aspirin use, diagnosis of hypertension and diabetes, age, race, and sex at birth and dependent variables of hearing loss and tinnitus. Results: A total of 90 271 patients with hyperlipidemia were included in this study. The analysis showed an association between the use of statins and sensorineural hearing loss (OR = 1.60, P <.01) as well as tinnitus (OR = 1.36, P <.01). In the individual statin analysis, simvastatin was associated with the strongest correlation with hearing loss (OR = 1.56, P <.01) and tinnitus (OR = 1.50, P <.01) while fluvastatin was the least associated both hearing loss (OR = 1.15, P <.01) and tinnitus (OR = 1.02, P =.68). Atorvastatin, the most used statin, was also associated with hearing loss (OR = 1.27, P <.01) and tinnitus (OR = 1.21, P <.01). Conclusion: In this study, the All of Us database was used to investigate the relationship between statins and hearing loss/tinnitus. Results indicate a potential ototoxic association of statins on hearing and tinnitus. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Objective: Hearing loss affects approximately 23% of Americans and is associated with medical comorbidities including hyperlipidemia. Statins, commonly used for dyslipidemia, may protect against hearing loss in animal models, but human studies show mixed results. This study aims to investigate statins and their effect on hearing loss and tinnitus. Methods: This study is a retrospective cohort study using the All of Us database. All of Us is a NIH-funded research database representing more than 710,000 participants in the United States. Patients with hyperlipidemia were labeled based on their exposure to at least 1 statin and additionally labeled for diagnoses of sensorineural hearing loss and/or tinnitus. Logistic regressions were performed with independent variables of statin use, aspirin use, diagnosis of hypertension and diabetes, age, race, and sex at birth and dependent variables of hearing loss and tinnitus. Results: A total of 90 271 patients with hyperlipidemia were included in this study. The analysis showed an association between the use of statins and sensorineural hearing loss (OR = 1.60, P <.01) as well as tinnitus (OR = 1.36, P <.01). In the individual statin analysis, simvastatin was associated with the strongest correlation with hearing loss (OR = 1.56, P <.01) and tinnitus (OR = 1.50, P <.01) while fluvastatin was the least associated both hearing loss (OR = 1.15, P <.01) and tinnitus (OR = 1.02, P =.68). Atorvastatin, the most used statin, was also associated with hearing loss (OR = 1.27, P <.01) and tinnitus (OR = 1.21, P <.01). Conclusion: In this study, the All of Us database was used to investigate the relationship between statins and hearing loss/tinnitus. Results indicate a potential ototoxic association of statins on hearing and tinnitus. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00034894 |
| DOI: | 10.1177/00034894251359135 |
