View in EDS HTML Full Text PDF Full Text

Statins and Their Effect on Hearing: An All of Us Database Study.

Saved in:
Bibliographic Details
Title: Statins and Their Effect on Hearing: An All of Us Database Study.
Authors: Homer, Benjamin J. (AUTHOR), Kasthuri, Viknesh S. (AUTHOR), Jain, Rishubh (AUTHOR), Homer, Alexander S. (AUTHOR), Gjini, Emily (AUTHOR), Noonan, Kathryn Y. (AUTHOR)
Source: Annals of Otology, Rhinology & Laryngology. Jan2026, Vol. 135 Issue 1, p20-26. 7p.
Subjects: Drug therapy for hyperlipidemia, Databases, Medical information storage & retrieval systems, Simvastatin, Risk assessment, Mitochondria, Research funding, Sensorineural hearing loss, Logistic regression analysis, Aspirin, Hypertension, Sex distribution, Fluvastatin, Population health, Retrospective studies, Age distribution, Multivariate analysis, Descriptive statistics, Tinnitus, Odds ratio, Race, Atorvastatin, Surveys, Statins (Cardiovascular agents), Medical records, Acquisition of data, Electronic health records, Hearing, Hearing disorders, Ototoxicity, Confidence intervals, Data analysis software, Diabetes, Disease risk factors
Geographic Terms: United States
Abstract: Objective: Hearing loss affects approximately 23% of Americans and is associated with medical comorbidities including hyperlipidemia. Statins, commonly used for dyslipidemia, may protect against hearing loss in animal models, but human studies show mixed results. This study aims to investigate statins and their effect on hearing loss and tinnitus. Methods: This study is a retrospective cohort study using the All of Us database. All of Us is a NIH-funded research database representing more than 710,000 participants in the United States. Patients with hyperlipidemia were labeled based on their exposure to at least 1 statin and additionally labeled for diagnoses of sensorineural hearing loss and/or tinnitus. Logistic regressions were performed with independent variables of statin use, aspirin use, diagnosis of hypertension and diabetes, age, race, and sex at birth and dependent variables of hearing loss and tinnitus. Results: A total of 90 271 patients with hyperlipidemia were included in this study. The analysis showed an association between the use of statins and sensorineural hearing loss (OR = 1.60, P <.01) as well as tinnitus (OR = 1.36, P <.01). In the individual statin analysis, simvastatin was associated with the strongest correlation with hearing loss (OR = 1.56, P <.01) and tinnitus (OR = 1.50, P <.01) while fluvastatin was the least associated both hearing loss (OR = 1.15, P <.01) and tinnitus (OR = 1.02, P =.68). Atorvastatin, the most used statin, was also associated with hearing loss (OR = 1.27, P <.01) and tinnitus (OR = 1.21, P <.01). Conclusion: In this study, the All of Us database was used to investigate the relationship between statins and hearing loss/tinnitus. Results indicate a potential ototoxic association of statins on hearing and tinnitus. [ABSTRACT FROM AUTHOR]
Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 190221811
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Statins and Their Effect on Hearing: An All of Us Database Study.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Homer%2C+Benjamin+J%2E%22&quot;&gt;Homer, Benjamin J.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kasthuri%2C+Viknesh+S%2E%22&quot;&gt;Kasthuri, Viknesh S.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jain%2C+Rishubh%22&quot;&gt;Jain, Rishubh&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Homer%2C+Alexander+S%2E%22&quot;&gt;Homer, Alexander S.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gjini%2C+Emily%22&quot;&gt;Gjini, Emily&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Noonan%2C+Kathryn+Y%2E%22&quot;&gt;Noonan, Kathryn Y.&lt;/searchLink&gt; (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Annals+of+Otology%2C+Rhinology+%26+Laryngology%22&quot;&gt;Annals of Otology, Rhinology &amp; Laryngology&lt;/searchLink&gt;. Jan2026, Vol. 135 Issue 1, p20-26. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Drug+therapy+for+hyperlipidemia%22&quot;&gt;Drug therapy for hyperlipidemia&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Databases%22&quot;&gt;Databases&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Medical+information+storage+%26+retrieval+systems%22&quot;&gt;Medical information storage &amp; retrieval systems&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Simvastatin%22&quot;&gt;Simvastatin&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Risk+assessment%22&quot;&gt;Risk assessment&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mitochondria%22&quot;&gt;Mitochondria&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Research+funding%22&quot;&gt;Research funding&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Sensorineural+hearing+loss%22&quot;&gt;Sensorineural hearing loss&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Logistic+regression+analysis%22&quot;&gt;Logistic regression analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Aspirin%22&quot;&gt;Aspirin&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Hypertension%22&quot;&gt;Hypertension&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Sex+distribution%22&quot;&gt;Sex distribution&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Fluvastatin%22&quot;&gt;Fluvastatin&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Population+health%22&quot;&gt;Population health&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Retrospective+studies%22&quot;&gt;Retrospective studies&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Age+distribution%22&quot;&gt;Age distribution&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Multivariate+analysis%22&quot;&gt;Multivariate analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Descriptive+statistics%22&quot;&gt;Descriptive statistics&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Tinnitus%22&quot;&gt;Tinnitus&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Odds+ratio%22&quot;&gt;Odds ratio&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Race%22&quot;&gt;Race&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Atorvastatin%22&quot;&gt;Atorvastatin&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Surveys%22&quot;&gt;Surveys&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Statins+%28Cardiovascular+agents%29%22&quot;&gt;Statins (Cardiovascular agents)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Medical+records%22&quot;&gt;Medical records&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Acquisition+of+data%22&quot;&gt;Acquisition of data&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Electronic+health+records%22&quot;&gt;Electronic health records&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Hearing%22&quot;&gt;Hearing&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Hearing+disorders%22&quot;&gt;Hearing disorders&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Ototoxicity%22&quot;&gt;Ototoxicity&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Confidence+intervals%22&quot;&gt;Confidence intervals&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Data+analysis+software%22&quot;&gt;Data analysis software&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Diabetes%22&quot;&gt;Diabetes&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Disease+risk+factors%22&quot;&gt;Disease risk factors&lt;/searchLink&gt;
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22United+States%22&quot;&gt;United States&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Hearing loss affects approximately 23% of Americans and is associated with medical comorbidities including hyperlipidemia. Statins, commonly used for dyslipidemia, may protect against hearing loss in animal models, but human studies show mixed results. This study aims to investigate statins and their effect on hearing loss and tinnitus. Methods: This study is a retrospective cohort study using the All of Us database. All of Us is a NIH-funded research database representing more than 710,000 participants in the United States. Patients with hyperlipidemia were labeled based on their exposure to at least 1 statin and additionally labeled for diagnoses of sensorineural hearing loss and/or tinnitus. Logistic regressions were performed with independent variables of statin use, aspirin use, diagnosis of hypertension and diabetes, age, race, and sex at birth and dependent variables of hearing loss and tinnitus. Results: A total of 90 271 patients with hyperlipidemia were included in this study. The analysis showed an association between the use of statins and sensorineural hearing loss (OR = 1.60, P &lt;.01) as well as tinnitus (OR = 1.36, P &lt;.01). In the individual statin analysis, simvastatin was associated with the strongest correlation with hearing loss (OR = 1.56, P &lt;.01) and tinnitus (OR = 1.50, P &lt;.01) while fluvastatin was the least associated both hearing loss (OR = 1.15, P &lt;.01) and tinnitus (OR = 1.02, P =.68). Atorvastatin, the most used statin, was also associated with hearing loss (OR = 1.27, P &lt;.01) and tinnitus (OR = 1.21, P &lt;.01). Conclusion: In this study, the All of Us database was used to investigate the relationship between statins and hearing loss/tinnitus. Results indicate a potential ototoxic association of statins on hearing and tinnitus. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Annals of Otology, Rhinology &amp; Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=190221811
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1177/00034894251359135
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 20
    Subjects:
      – SubjectFull: Drug therapy for hyperlipidemia
        Type: general
      – SubjectFull: Databases
        Type: general
      – SubjectFull: Medical information storage & retrieval systems
        Type: general
      – SubjectFull: Simvastatin
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Mitochondria
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Sensorineural hearing loss
        Type: general
      – SubjectFull: Logistic regression analysis
        Type: general
      – SubjectFull: Aspirin
        Type: general
      – SubjectFull: Hypertension
        Type: general
      – SubjectFull: Sex distribution
        Type: general
      – SubjectFull: Fluvastatin
        Type: general
      – SubjectFull: Population health
        Type: general
      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Age distribution
        Type: general
      – SubjectFull: Multivariate analysis
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Tinnitus
        Type: general
      – SubjectFull: Odds ratio
        Type: general
      – SubjectFull: Race
        Type: general
      – SubjectFull: Atorvastatin
        Type: general
      – SubjectFull: Surveys
        Type: general
      – SubjectFull: Statins (Cardiovascular agents)
        Type: general
      – SubjectFull: Medical records
        Type: general
      – SubjectFull: Acquisition of data
        Type: general
      – SubjectFull: Electronic health records
        Type: general
      – SubjectFull: Hearing
        Type: general
      – SubjectFull: Hearing disorders
        Type: general
      – SubjectFull: Ototoxicity
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Diabetes
        Type: general
      – SubjectFull: Disease risk factors
        Type: general
      – SubjectFull: United States
        Type: general
    Titles:
      – TitleFull: Statins and Their Effect on Hearing: An All of Us Database Study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Homer, Benjamin J.
      – PersonEntity:
          Name:
            NameFull: Kasthuri, Viknesh S.
      – PersonEntity:
          Name:
            NameFull: Jain, Rishubh
      – PersonEntity:
          Name:
            NameFull: Homer, Alexander S.
      – PersonEntity:
          Name:
            NameFull: Gjini, Emily
      – PersonEntity:
          Name:
            NameFull: Noonan, Kathryn Y.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: Jan2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 00034894
          Numbering:
            – Type: volume
              Value: 135
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Annals of Otology, Rhinology & Laryngology
              Type: main
ResultId 1