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Mismatch Negativity and P3a in Unaffected Siblings of Individuals with Autism Spectrum Disorder and the Exploration on the Neurocognitive Implications.

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Title: Mismatch Negativity and P3a in Unaffected Siblings of Individuals with Autism Spectrum Disorder and the Exploration on the Neurocognitive Implications.
Authors: Chien, Yi-Ling (AUTHOR), Hsieh, Ming H. (AUTHOR), Gau, Susan Shur-Fen (AUTHOR)
Source: Journal of Autism & Developmental Disorders. Jan2026, Vol. 56 Issue 1, p256-268. 13p.
Subjects: Brain physiology, Intellect, Statistical correlation, Cross-sectional method, Pearson correlation (Statistics), Cognitive testing, Task performance, Research funding, T-test (Statistics), Autism, Neural development, Questionnaires, Electroencephalography, Sex distribution, Age distribution, Descriptive statistics, Analysis of covariance, Mann Whitney U Test, Attention, Neuropsychology, Neuropsychological tests, Asperger's syndrome, Short-term memory, Visual perception, Auditory perception, Data analysis software, Comparative studies, Auditory evoked response, Electrophysiology, Phenotypes
Geographic Terms: Taiwan
Abstract: Evidence suggests different mismatch negativity (MMN) and P3a responses in individuals with autism spectrum disorder (ASD). Since unaffected siblings shared aberrant neurocognition and brain connectivity with ASD probands, this study investigated MMN and P3a responses in unaffected siblings and explored its neurocognitive implications and effects modifiers. We assessed 43 unaffected siblings of ASD probands and 64 non-autistic comparisons (NTC) using MMN and P3a on both frequency and duration oddball paradigms. The amplitude and latency of MMN and P3a were compared between unaffected siblings and NTC, and validated in 67 ASD probands. In addition, the neurocognitive correlates of MMN and P3a parameters were explored in attention performance, spatial working memory (SWM), and visual research via the tasks of the Conners' Continuous Performance Test and the Cambridge Neuropsychological Test Automated Battery. Compared to NTC, unaffected siblings and ASD probands presented a shorter MMN latency. The P3a amplitude of the duration paradigm (dP3a) was correlated with fewer commission errors, fewer SWM total errors, higher detectability, and more correct responses on visual search tasks. In addition, the dP3a amplitude significantly interacted with sibship, age, and full-scale IQ to predict attention performance, SWM total errors, and total correct response on visual search. Findings suggest that unaffected siblings of ASD may have earlier brain responses upon novelty discrimination. P3a amplitude may correlate with better neurocognitive performance, but the effect was moderated by sibship, age, and intelligence. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Mismatch Negativity and P3a in Unaffected Siblings of Individuals with Autism Spectrum Disorder and the Exploration on the Neurocognitive Implications.
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Autism+%26+Developmental+Disorders%22">Journal of Autism & Developmental Disorders</searchLink>. Jan2026, Vol. 56 Issue 1, p256-268. 13p.
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  Data: Evidence suggests different mismatch negativity (MMN) and P3a responses in individuals with autism spectrum disorder (ASD). Since unaffected siblings shared aberrant neurocognition and brain connectivity with ASD probands, this study investigated MMN and P3a responses in unaffected siblings and explored its neurocognitive implications and effects modifiers. We assessed 43 unaffected siblings of ASD probands and 64 non-autistic comparisons (NTC) using MMN and P3a on both frequency and duration oddball paradigms. The amplitude and latency of MMN and P3a were compared between unaffected siblings and NTC, and validated in 67 ASD probands. In addition, the neurocognitive correlates of MMN and P3a parameters were explored in attention performance, spatial working memory (SWM), and visual research via the tasks of the Conners' Continuous Performance Test and the Cambridge Neuropsychological Test Automated Battery. Compared to NTC, unaffected siblings and ASD probands presented a shorter MMN latency. The P3a amplitude of the duration paradigm (dP3a) was correlated with fewer commission errors, fewer SWM total errors, higher detectability, and more correct responses on visual search tasks. In addition, the dP3a amplitude significantly interacted with sibship, age, and full-scale IQ to predict attention performance, SWM total errors, and total correct response on visual search. Findings suggest that unaffected siblings of ASD may have earlier brain responses upon novelty discrimination. P3a amplitude may correlate with better neurocognitive performance, but the effect was moderated by sibship, age, and intelligence. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10803-024-06520-1
    Languages:
      – Code: eng
        Text: English
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        StartPage: 256
    Subjects:
      – SubjectFull: Brain physiology
        Type: general
      – SubjectFull: Intellect
        Type: general
      – SubjectFull: Statistical correlation
        Type: general
      – SubjectFull: Cross-sectional method
        Type: general
      – SubjectFull: Pearson correlation (Statistics)
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      – SubjectFull: Cognitive testing
        Type: general
      – SubjectFull: Task performance
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: T-test (Statistics)
        Type: general
      – SubjectFull: Autism
        Type: general
      – SubjectFull: Neural development
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Electroencephalography
        Type: general
      – SubjectFull: Sex distribution
        Type: general
      – SubjectFull: Age distribution
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Analysis of covariance
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      – SubjectFull: Mann Whitney U Test
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      – SubjectFull: Attention
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      – SubjectFull: Neuropsychology
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      – SubjectFull: Neuropsychological tests
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      – SubjectFull: Asperger's syndrome
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      – SubjectFull: Comparative studies
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      – SubjectFull: Auditory evoked response
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      – SubjectFull: Electrophysiology
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      – SubjectFull: Phenotypes
        Type: general
      – SubjectFull: Taiwan
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    Titles:
      – TitleFull: Mismatch Negativity and P3a in Unaffected Siblings of Individuals with Autism Spectrum Disorder and the Exploration on the Neurocognitive Implications.
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              Text: Jan2026
              Type: published
              Y: 2026
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