View in EDS

Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery.

Saved in:
Bibliographic Details
Title: Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery.
Authors: Zhang, Chu-Yi (AUTHOR), Li, Miao (AUTHOR), Sun, Ping (AUTHOR), Hui, Li (AUTHOR), Gao, Yuan (AUTHOR), Yang, Jian-Zhong (AUTHOR), Zhang, Nan (AUTHOR), Feng, Xiaoyang (AUTHOR), Wu, Yong (AUTHOR), Guo, Lei (AUTHOR), Yuan, Jing (AUTHOR), Jiang, Hong-Yan (AUTHOR), Cheng, Yu-Qi (AUTHOR), Ma, Simeng (AUTHOR), Gong, Qian (AUTHOR), Sun, Yaoyao (AUTHOR), Li, Yi (AUTHOR), Qu, Na (AUTHOR), Yin, Xu-Yuan (AUTHOR), Wang, Lu (AUTHOR)
Source: Nature Neuroscience. Feb2026, Vol. 29 Issue 2, p293-305. 13p.
Abstract: Genome-wide association studies (GWASs) of bipolar disorder (BD) have predominantly included individuals of European (EUR) ancestry, underrepresenting non-EUR populations and limiting insight into disease mechanisms. Here we performed a GWAS of BD in Han Chinese individuals (5,164 cases and 13,460 controls) and conducted comparative and integrative analyses with independent East Asian (EAS, 4,479 cases and 75,725 controls) and EUR (59,287 cases and 781,022 controls) cohorts from the PGC4 GWAS. Our GWAS in EAS ancestry identified two genome-wide significant risk loci, including variants at the major histocompatibility complex (MHC) class II region. Incorporating EAS data into trans-ancestry GWAS revealed 93 significant loci (23 novel). Heritability enrichment analyses implicated a variety of neuronal cell types. Multidimensional post-GWAS prioritization identified 39 high-confidence risk genes, of which 15 were differentially expressed in the brains of patients with BD, 12 modulated BD-relevant behaviors in mice and 18 are pharmacologically tractable. This work advances understanding of the biological underpinnings of BD and provides direction for future research in underrepresented populations. The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 191453125
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Zhang%2C+Chu-Yi%22">Zhang, Chu-Yi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Miao%22">Li, Miao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Ping%22">Sun, Ping</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hui%2C+Li%22">Hui, Li</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gao%2C+Yuan%22">Gao, Yuan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Jian-Zhong%22">Yang, Jian-Zhong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Nan%22">Zhang, Nan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Feng%2C+Xiaoyang%22">Feng, Xiaoyang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Yong%22">Wu, Yong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guo%2C+Lei%22">Guo, Lei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yuan%2C+Jing%22">Yuan, Jing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiang%2C+Hong-Yan%22">Jiang, Hong-Yan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cheng%2C+Yu-Qi%22">Cheng, Yu-Qi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ma%2C+Simeng%22">Ma, Simeng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gong%2C+Qian%22">Gong, Qian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Yaoyao%22">Sun, Yaoyao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Yi%22">Li, Yi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qu%2C+Na%22">Qu, Na</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yin%2C+Xu-Yuan%22">Yin, Xu-Yuan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Lu%22">Wang, Lu</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Feb2026, Vol. 29 Issue 2, p293-305. 13p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Genome-wide association studies (GWASs) of bipolar disorder (BD) have predominantly included individuals of European (EUR) ancestry, underrepresenting non-EUR populations and limiting insight into disease mechanisms. Here we performed a GWAS of BD in Han Chinese individuals (5,164 cases and 13,460 controls) and conducted comparative and integrative analyses with independent East Asian (EAS, 4,479 cases and 75,725 controls) and EUR (59,287 cases and 781,022 controls) cohorts from the PGC4 GWAS. Our GWAS in EAS ancestry identified two genome-wide significant risk loci, including variants at the major histocompatibility complex (MHC) class II region. Incorporating EAS data into trans-ancestry GWAS revealed 93 significant loci (23 novel). Heritability enrichment analyses implicated a variety of neuronal cell types. Multidimensional post-GWAS prioritization identified 39 high-confidence risk genes, of which 15 were differentially expressed in the brains of patients with BD, 12 modulated BD-relevant behaviors in mice and 18 are pharmacologically tractable. This work advances understanding of the biological underpinnings of BD and provides direction for future research in underrepresented populations. The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=191453125
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41593-025-02147-2
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 13
        StartPage: 293
    Titles:
      – TitleFull: Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Zhang, Chu-Yi
      – PersonEntity:
          Name:
            NameFull: Li, Miao
      – PersonEntity:
          Name:
            NameFull: Sun, Ping
      – PersonEntity:
          Name:
            NameFull: Hui, Li
      – PersonEntity:
          Name:
            NameFull: Gao, Yuan
      – PersonEntity:
          Name:
            NameFull: Yang, Jian-Zhong
      – PersonEntity:
          Name:
            NameFull: Zhang, Nan
      – PersonEntity:
          Name:
            NameFull: Feng, Xiaoyang
      – PersonEntity:
          Name:
            NameFull: Wu, Yong
      – PersonEntity:
          Name:
            NameFull: Guo, Lei
      – PersonEntity:
          Name:
            NameFull: Yuan, Jing
      – PersonEntity:
          Name:
            NameFull: Jiang, Hong-Yan
      – PersonEntity:
          Name:
            NameFull: Cheng, Yu-Qi
      – PersonEntity:
          Name:
            NameFull: Ma, Simeng
      – PersonEntity:
          Name:
            NameFull: Gong, Qian
      – PersonEntity:
          Name:
            NameFull: Sun, Yaoyao
      – PersonEntity:
          Name:
            NameFull: Li, Yi
      – PersonEntity:
          Name:
            NameFull: Qu, Na
      – PersonEntity:
          Name:
            NameFull: Yin, Xu-Yuan
      – PersonEntity:
          Name:
            NameFull: Wang, Lu
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: Feb2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 10976256
          Numbering:
            – Type: volume
              Value: 29
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Nature Neuroscience
              Type: main
ResultId 1