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Socio‐economic differences in the effectiveness of pharmacotherapy use in alcohol use disorder: A cohort study of 148 626 individuals in Sweden.

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Title: Socio‐economic differences in the effectiveness of pharmacotherapy use in alcohol use disorder: A cohort study of 148 626 individuals in Sweden.
Authors: Elling, Devy L., Thern, Emelie, Mangot‐Sala, Lluís, Tiihonen, Jari, Hammarberg, Anders, Falkstedt, Daniel, Taipale, Heidi
Source: Addiction. Mar2026, Vol. 121 Issue 3, p597-605. 9p.
Subjects: Patient compliance, Risk assessment, Research funding, Alcohol deterrents, Hospital care, Socioeconomic factors, Sex distribution, Patient readmissions, Treatment effectiveness, Descriptive statistics, Age distribution, Longitudinal method, Odds ratio, Acamprosate calcium, Drug efficacy, Alcoholism, Comparative studies, Data analysis software, Confidence intervals, Sociodemographic factors, Length of stay in hospitals, Regression analysis, Disulfiram, Naltrexone, Evaluation
Geographic Terms: Sweden
Abstract: Aim: To examine the socioeconomic differences in the effectiveness of alcohol use disorders (AUD) pharmacotherapy and risk of AUD hospitalisation. Design: A prospective register‐based cohort study. Setting: Sweden. Participants: Individuals who were registered as living in Sweden in 2005 (16–64 years) with a first‐time AUD diagnosis and complete information on their socioeconomic position (SEP) between 2005 and 2019 (n = 148 626). Measurement The outcome was AUD hospitalisation. The use of AUD pharmacotherapy was treated as a time‐varying exposure. SEP was the moderator. The association between the joint‐exposure (pharmacotherapy use and SEP) and AUD hospitalisation was assessed using a competing‐risk regression model, adjusted for sociodemographic factors, previous mental health diagnoses and use of other psychiatric medications. Findings Pharmacotherapy use was associated with a lower risk of AUD hospitalisation among high SEP individuals [subdistribution hazard ratio (SHR) = 0.83, 95% confidence interval (CI) = 0.77–0.90], but not among those with low SEP (SHR = 1.02, 95% CI = 0.94–1.10) and middle SEP (SHR = 1.01, 95% CI = 0.94–1.09), compared with low SEP individuals when not using pharmacotherapy. Conclusions: In Sweden, alcohol use disorder (AUD) pharmacotherapy appears to be effective to reduce the risk of AUD hospitalisation only among individuals of high socioeconomic position. [ABSTRACT FROM AUTHOR]
Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Socio‐economic differences in the effectiveness of pharmacotherapy use in alcohol use disorder: A cohort study of 148 626 individuals in Sweden.
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  Data: <searchLink fieldCode="JN" term="%22Addiction%22">Addiction</searchLink>. Mar2026, Vol. 121 Issue 3, p597-605. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Patient+compliance%22">Patient compliance</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Alcohol+deterrents%22">Alcohol deterrents</searchLink><br /><searchLink fieldCode="DE" term="%22Hospital+care%22">Hospital care</searchLink><br /><searchLink fieldCode="DE" term="%22Socioeconomic+factors%22">Socioeconomic factors</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+distribution%22">Sex distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+readmissions%22">Patient readmissions</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Age+distribution%22">Age distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Acamprosate+calcium%22">Acamprosate calcium</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+efficacy%22">Drug efficacy</searchLink><br /><searchLink fieldCode="DE" term="%22Alcoholism%22">Alcoholism</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Sociodemographic+factors%22">Sociodemographic factors</searchLink><br /><searchLink fieldCode="DE" term="%22Length+of+stay+in+hospitals%22">Length of stay in hospitals</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Disulfiram%22">Disulfiram</searchLink><br /><searchLink fieldCode="DE" term="%22Naltrexone%22">Naltrexone</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation%22">Evaluation</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Sweden%22">Sweden</searchLink>
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  Label: Abstract
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  Data: Aim: To examine the socioeconomic differences in the effectiveness of alcohol use disorders (AUD) pharmacotherapy and risk of AUD hospitalisation. Design: A prospective register‐based cohort study. Setting: Sweden. Participants: Individuals who were registered as living in Sweden in 2005 (16–64 years) with a first‐time AUD diagnosis and complete information on their socioeconomic position (SEP) between 2005 and 2019 (n = 148 626). Measurement The outcome was AUD hospitalisation. The use of AUD pharmacotherapy was treated as a time‐varying exposure. SEP was the moderator. The association between the joint‐exposure (pharmacotherapy use and SEP) and AUD hospitalisation was assessed using a competing‐risk regression model, adjusted for sociodemographic factors, previous mental health diagnoses and use of other psychiatric medications. Findings Pharmacotherapy use was associated with a lower risk of AUD hospitalisation among high SEP individuals [subdistribution hazard ratio (SHR) = 0.83, 95% confidence interval (CI) = 0.77–0.90], but not among those with low SEP (SHR = 1.02, 95% CI = 0.94–1.10) and middle SEP (SHR = 1.01, 95% CI = 0.94–1.09), compared with low SEP individuals when not using pharmacotherapy. Conclusions: In Sweden, alcohol use disorder (AUD) pharmacotherapy appears to be effective to reduce the risk of AUD hospitalisation only among individuals of high socioeconomic position. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=191490923
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        Value: 10.1111/add.70238
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        Text: English
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      – SubjectFull: Research funding
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      – SubjectFull: Alcohol deterrents
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      – SubjectFull: Sex distribution
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      – SubjectFull: Odds ratio
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