View in EDS HTML Full Text PDF Full Text

Network Analysis Identifies T‐Type Voltage‐Sensitive Calcium Channels, Kainate Receptors and cAMP Signalling Regulators as Potential Mediators Linking the Pathophysiology of Obsessive Compulsive Disorder (OCD) and Dementia.

Saved in:
Bibliographic Details
Title: Network Analysis Identifies T‐Type Voltage‐Sensitive Calcium Channels, Kainate Receptors and cAMP Signalling Regulators as Potential Mediators Linking the Pathophysiology of Obsessive Compulsive Disorder (OCD) and Dementia.
Authors: Joshi, Antara (AUTHOR), Mitra, Bhumika (AUTHOR), Sudesh, Ravi (AUTHOR), Arumugam, Mohanapriya (AUTHOR), Balakrishnan, Balaji (AUTHOR), Haque, Shafiul (AUTHOR), Lage, Miguel Angel Prieto (AUTHOR), Ahmad, Faraz (AUTHOR), Liampas, Ioannis (AUTHOR)
Source: Acta Neurologica Scandinavica. 3/26/2026, Vol. 2026, p1-23. 23p.
Subjects: Obsessive-compulsive disorder, Dementia, Cyclic adenylic acid, Pathological physiology, Excitatory amino acids, Genome-wide association studies, Calcium channels, Systems biology
Abstract: Obsessive compulsive disorder (OCD) is a challenging mental health condition marked by intrusive thoughts and repetitive actions intended to reduce anxiety or prevent potential harm. Dementia encompasses a range of degenerative brain conditions distinguished by diminished cognitive abilities, memory impairment and challenges in everyday activities. Clinical data suggests a probable association between OCD and dementia, with individuals exhibiting obsessive–compulsive symptoms showing higher risk of developing dementia, like Alzheimer′s disease. However, the underlying mechanisms linking the two conditions are largely unknown. This in silico network analysis is aimed at understanding the common molecular determinants underlying the pathophysiology of OCD and dementia. For this purpose, genome‐wide association study (GWAS) databases were used to identify the genes involved in the pathogeneses of both conditions. Subsequent network analyses of the common genes found to be altered in OCD and dementia was performed to identify potential shared biological pathways and their pathophysiological implications. Our findings indicated significant pathway enrichment and common dysregulated gene modules in both diseases, indicating potential convergence spots for targeted therapeutic approaches. In particular, T‐type voltage‐sensitive calcium channels, kainate receptors and cAMP signalling regulators were recognized as key mediators linking the pathophysiology of OCD and dementia. Although further experimental data is warranted, our gene set enrichment analysis results may aid in understanding the pathophysiology of these disorders, particularly in cases where they coexist. Further, hub genes linking the two conditions constitute hypothesis‐generating leads and promising targets for experimental validation aimed at tackling the intricately interlinked aetiology of dementia and OCD. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 192556098
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Network Analysis Identifies T‐Type Voltage‐Sensitive Calcium Channels, Kainate Receptors and cAMP Signalling Regulators as Potential Mediators Linking the Pathophysiology of Obsessive Compulsive Disorder (OCD) and Dementia.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Joshi%2C+Antara%22">Joshi, Antara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mitra%2C+Bhumika%22">Mitra, Bhumika</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sudesh%2C+Ravi%22">Sudesh, Ravi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arumugam%2C+Mohanapriya%22">Arumugam, Mohanapriya</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Balakrishnan%2C+Balaji%22">Balakrishnan, Balaji</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Haque%2C+Shafiul%22">Haque, Shafiul</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lage%2C+Miguel+Angel+Prieto%22">Lage, Miguel Angel Prieto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ahmad%2C+Faraz%22">Ahmad, Faraz</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liampas%2C+Ioannis%22">Liampas, Ioannis</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. 3/26/2026, Vol. 2026, p1-23. 23p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Obsessive-compulsive+disorder%22">Obsessive-compulsive disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Dementia%22">Dementia</searchLink><br /><searchLink fieldCode="DE" term="%22Cyclic+adenylic+acid%22">Cyclic adenylic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+physiology%22">Pathological physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Excitatory+amino+acids%22">Excitatory amino acids</searchLink><br /><searchLink fieldCode="DE" term="%22Genome-wide+association+studies%22">Genome-wide association studies</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+channels%22">Calcium channels</searchLink><br /><searchLink fieldCode="DE" term="%22Systems+biology%22">Systems biology</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Obsessive compulsive disorder (OCD) is a challenging mental health condition marked by intrusive thoughts and repetitive actions intended to reduce anxiety or prevent potential harm. Dementia encompasses a range of degenerative brain conditions distinguished by diminished cognitive abilities, memory impairment and challenges in everyday activities. Clinical data suggests a probable association between OCD and dementia, with individuals exhibiting obsessive–compulsive symptoms showing higher risk of developing dementia, like Alzheimer′s disease. However, the underlying mechanisms linking the two conditions are largely unknown. This in silico network analysis is aimed at understanding the common molecular determinants underlying the pathophysiology of OCD and dementia. For this purpose, genome‐wide association study (GWAS) databases were used to identify the genes involved in the pathogeneses of both conditions. Subsequent network analyses of the common genes found to be altered in OCD and dementia was performed to identify potential shared biological pathways and their pathophysiological implications. Our findings indicated significant pathway enrichment and common dysregulated gene modules in both diseases, indicating potential convergence spots for targeted therapeutic approaches. In particular, T‐type voltage‐sensitive calcium channels, kainate receptors and cAMP signalling regulators were recognized as key mediators linking the pathophysiology of OCD and dementia. Although further experimental data is warranted, our gene set enrichment analysis results may aid in understanding the pathophysiology of these disorders, particularly in cases where they coexist. Further, hub genes linking the two conditions constitute hypothesis‐generating leads and promising targets for experimental validation aimed at tackling the intricately interlinked aetiology of dementia and OCD. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=192556098
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1155/ane/7255903
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 23
        StartPage: 1
    Subjects:
      – SubjectFull: Obsessive-compulsive disorder
        Type: general
      – SubjectFull: Dementia
        Type: general
      – SubjectFull: Cyclic adenylic acid
        Type: general
      – SubjectFull: Pathological physiology
        Type: general
      – SubjectFull: Excitatory amino acids
        Type: general
      – SubjectFull: Genome-wide association studies
        Type: general
      – SubjectFull: Calcium channels
        Type: general
      – SubjectFull: Systems biology
        Type: general
    Titles:
      – TitleFull: Network Analysis Identifies T‐Type Voltage‐Sensitive Calcium Channels, Kainate Receptors and cAMP Signalling Regulators as Potential Mediators Linking the Pathophysiology of Obsessive Compulsive Disorder (OCD) and Dementia.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Joshi, Antara
      – PersonEntity:
          Name:
            NameFull: Mitra, Bhumika
      – PersonEntity:
          Name:
            NameFull: Sudesh, Ravi
      – PersonEntity:
          Name:
            NameFull: Arumugam, Mohanapriya
      – PersonEntity:
          Name:
            NameFull: Balakrishnan, Balaji
      – PersonEntity:
          Name:
            NameFull: Haque, Shafiul
      – PersonEntity:
          Name:
            NameFull: Lage, Miguel Angel Prieto
      – PersonEntity:
          Name:
            NameFull: Ahmad, Faraz
      – PersonEntity:
          Name:
            NameFull: Liampas, Ioannis
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 26
              M: 03
              Text: 3/26/2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 00016314
          Numbering:
            – Type: volume
              Value: 2026
          Titles:
            – TitleFull: Acta Neurologica Scandinavica
              Type: main
ResultId 1