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Outcomes of an Exercise Intervention in Adults With Down Syndrome and Congenital Heart Disease: A Secondary Analysis.

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Title: Outcomes of an Exercise Intervention in Adults With Down Syndrome and Congenital Heart Disease: A Secondary Analysis.
Authors: Clina, Julianne G. (AUTHOR), Helsel, Brian C. (AUTHOR), White, David A. (AUTHOR), Sherman, Joseph R. (AUTHOR), Rice, Anna M. (AUTHOR), Forsha, Daniel E. (AUTHOR), Danon, Jessica C. (AUTHOR), Bodde, Amy E. (AUTHOR), Donnelly, Joseph E. (AUTHOR), Washburn, Richard A. (AUTHOR), Ptomey, Lauren T. (AUTHOR)
Source: Journal of Intellectual Disability Research. May2026, Vol. 70 Issue 5, p491-499. 9p.
Subjects: Congenital heart disease, Exercise physiology, Cardiopulmonary fitness, Poisson distribution, Down syndrome, Patient safety, Secondary analysis, Research funding, Exercise therapy, Accelerometry, Exercise intensity, Hemodynamics, Descriptive statistics, Chi-squared test, Mann Whitney U Test, Heart beat, Blood pressure, Physical activity
Abstract: Background: Adults with Down syndrome (DS) are less physically active than those without DS. Among adults with DS, those with congenital heart disease (CHD) have lower physical activity than those without CHD. Many trials exclude people with CHD from exercise trials; thus, the safety and effectiveness of these interventions for increasing physical activity and fitness in adults with DS and CHD are not known. The purpose of this analysis was to evaluate the safety and preliminary effectiveness of an exercise intervention in adults with DS and CHD for increasing physical activity and fitness. Method: This secondary analysis used data from a 12‐month randomized controlled physical activity intervention for adults with DS. Safety of the intervention was assessed as number and severity of adverse events and compared by CHD status. Changes in physical activity (accelerometry) and fitness (VO2peak) among those with CHD were evaluated using mixed effects models. Results: Thirty‐six participants had CHD and were randomized to one of the exercise intervention arms (average age 25.5 years, 55.6% female). There were no differences in number (CHD: 18 vs. no CHD 22 events; rate ratio 1.02, p = 0.94) or severity (p = 0.25) of adverse events between those with and without CHD. Participants significantly increased moderate‐to‐vigorous physical activity minutes per day (+8.6 min/day, p = 0.045) and VO2peak (+2.1 mL/kg/min, p = 0.036). Discussion: Results from this analysis show preliminary support for young adults with DS and CHD to safely participate in exercise interventions that are appropriately designed for their inclusion. These interventions also demonstrate preliminary effectiveness for increasing physical activity and fitness. Findings should be repeated and confirmed in a larger, more diverse sample to understand the safety and impact of exercise on health in persons with DS and CHD. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Intellectual Disability Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Outcomes of an Exercise Intervention in Adults With Down Syndrome and Congenital Heart Disease: A Secondary Analysis.
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  Data: <searchLink fieldCode="AR" term="%22Clina%2C+Julianne G%2E%22">Clina, Julianne G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Helsel%2C+Brian C%2E%22">Helsel, Brian C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22White%2C+David A%2E%22">White, David A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sherman%2C+Joseph R%2E%22">Sherman, Joseph R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rice%2C+Anna M%2E%22">Rice, Anna M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Forsha%2C+Daniel E%2E%22">Forsha, Daniel E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Danon%2C+Jessica C%2E%22">Danon, Jessica C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bodde%2C+Amy E%2E%22">Bodde, Amy E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Donnelly%2C+Joseph E%2E%22">Donnelly, Joseph E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Washburn%2C+Richard A%2E%22">Washburn, Richard A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ptomey%2C+Lauren T%2E%22">Ptomey, Lauren T.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Intellectual+Disability+Research%22">Journal of Intellectual Disability Research</searchLink>. May2026, Vol. 70 Issue 5, p491-499. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Congenital+heart+disease%22">Congenital heart disease</searchLink><br /><searchLink fieldCode="DE" term="%22Exercise+physiology%22">Exercise physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiopulmonary+fitness%22">Cardiopulmonary fitness</searchLink><br /><searchLink fieldCode="DE" term="%22Poisson+distribution%22">Poisson distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Down+syndrome%22">Down syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+safety%22">Patient safety</searchLink><br /><searchLink fieldCode="DE" term="%22Secondary+analysis%22">Secondary analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Exercise+therapy%22">Exercise therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Accelerometry%22">Accelerometry</searchLink><br /><searchLink fieldCode="DE" term="%22Exercise+intensity%22">Exercise intensity</searchLink><br /><searchLink fieldCode="DE" term="%22Hemodynamics%22">Hemodynamics</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Mann+Whitney+U+Test%22">Mann Whitney U Test</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+beat%22">Heart beat</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+pressure%22">Blood pressure</searchLink><br /><searchLink fieldCode="DE" term="%22Physical+activity%22">Physical activity</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Adults with Down syndrome (DS) are less physically active than those without DS. Among adults with DS, those with congenital heart disease (CHD) have lower physical activity than those without CHD. Many trials exclude people with CHD from exercise trials; thus, the safety and effectiveness of these interventions for increasing physical activity and fitness in adults with DS and CHD are not known. The purpose of this analysis was to evaluate the safety and preliminary effectiveness of an exercise intervention in adults with DS and CHD for increasing physical activity and fitness. Method: This secondary analysis used data from a 12‐month randomized controlled physical activity intervention for adults with DS. Safety of the intervention was assessed as number and severity of adverse events and compared by CHD status. Changes in physical activity (accelerometry) and fitness (VO2peak) among those with CHD were evaluated using mixed effects models. Results: Thirty‐six participants had CHD and were randomized to one of the exercise intervention arms (average age 25.5 years, 55.6% female). There were no differences in number (CHD: 18 vs. no CHD 22 events; rate ratio 1.02, p = 0.94) or severity (p = 0.25) of adverse events between those with and without CHD. Participants significantly increased moderate‐to‐vigorous physical activity minutes per day (+8.6 min/day, p = 0.045) and VO2peak (+2.1 mL/kg/min, p = 0.036). Discussion: Results from this analysis show preliminary support for young adults with DS and CHD to safely participate in exercise interventions that are appropriately designed for their inclusion. These interventions also demonstrate preliminary effectiveness for increasing physical activity and fitness. Findings should be repeated and confirmed in a larger, more diverse sample to understand the safety and impact of exercise on health in persons with DS and CHD. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Intellectual Disability Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=192872545
RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1111/jir.70087
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      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 491
    Subjects:
      – SubjectFull: Congenital heart disease
        Type: general
      – SubjectFull: Exercise physiology
        Type: general
      – SubjectFull: Cardiopulmonary fitness
        Type: general
      – SubjectFull: Poisson distribution
        Type: general
      – SubjectFull: Down syndrome
        Type: general
      – SubjectFull: Patient safety
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      – SubjectFull: Secondary analysis
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Exercise therapy
        Type: general
      – SubjectFull: Accelerometry
        Type: general
      – SubjectFull: Exercise intensity
        Type: general
      – SubjectFull: Hemodynamics
        Type: general
      – SubjectFull: Descriptive statistics
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      – SubjectFull: Chi-squared test
        Type: general
      – SubjectFull: Mann Whitney U Test
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      – SubjectFull: Heart beat
        Type: general
      – SubjectFull: Blood pressure
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      – SubjectFull: Physical activity
        Type: general
    Titles:
      – TitleFull: Outcomes of an Exercise Intervention in Adults With Down Syndrome and Congenital Heart Disease: A Secondary Analysis.
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              Text: May2026
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