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Association between telomere length and psychiatric disorders: a bidirectional Mendelian randomization study.

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Title: Association between telomere length and psychiatric disorders: a bidirectional Mendelian randomization study.
Authors: Zhang, Han (AUTHOR), Zhou, Jing (AUTHOR), Cao, Yuan (AUTHOR), Zhang, Xiaoan (AUTHOR), Chang, Hui (AUTHOR), Zhao, Yan (AUTHOR), Bo, Yacong (AUTHOR), Zhang, Huanhuan (AUTHOR), Yu, Zengli (AUTHOR), Zhao, Xin (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Jun2026, Vol. 276 Issue 4, p1959-1966. 8p.
Subjects: Attention-deficit hyperactivity disorder, Post-traumatic stress disorder, Biomarkers, Mental illness, Causal inference, Genetic risk score, Mendelian randomization
Abstract: Observational studies have suggested that shorter telomere length (TL) may be a risk factor for psychiatric disorders. However, whether this association underlie causal effects remains unknown. This study aims to investigate the potential association between TL and psychiatric disorders by conducting a bidirectional Mendelian randomization (MR) study. Summary statistics for TL were obtained from the UK Biobank (n = 472,174), while summary statistics for ten psychiatric disorders were acquired from the Psychiatric Genomics Consortium (PGC). The inverse-variance weighted (IVW) method was used as primary analysis, with the MR-Egger, weighted median, MR-PRESSO, simple mode, and weighted mode approaches were utilized as sensitivity analyses. Our findings indicated a potential association between genetic predisposition to attention deficit hyperactivity disorder (ADHD) and shortened TL (Beta = − 0.039, SE = 0.011, P = 4.00E-04). Additionally, posttraumatic stress disorder (PTSD) may be was potentially associated with TL (Beta = − 0.014, SE = 0.006, P = 0.019). Our findings suggest a potential correlation between ADHD and TL, yet no significant association exists between TL and other psychiatric disorders. Nevertheless, considering the small effect size and the fact that it might have limited practical clinical significance, TL may not function as a biomarker for psychiatric disorders. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Association between telomere length and psychiatric disorders: a bidirectional Mendelian randomization study.
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  Data: <searchLink fieldCode="AR" term="%22Zhang%2C+Han%22">Zhang, Han</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Jing%22">Zhou, Jing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cao%2C+Yuan%22">Cao, Yuan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Xiaoan%22">Zhang, Xiaoan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chang%2C+Hui%22">Chang, Hui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhao%2C+Yan%22">Zhao, Yan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bo%2C+Yacong%22">Bo, Yacong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Huanhuan%22">Zhang, Huanhuan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yu%2C+Zengli%22">Yu, Zengli</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhao%2C+Xin%22">Zhao, Xin</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Jun2026, Vol. 276 Issue 4, p1959-1966. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Post-traumatic+stress+disorder%22">Post-traumatic stress disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+illness%22">Mental illness</searchLink><br /><searchLink fieldCode="DE" term="%22Causal+inference%22">Causal inference</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+risk+score%22">Genetic risk score</searchLink><br /><searchLink fieldCode="DE" term="%22Mendelian+randomization%22">Mendelian randomization</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Observational studies have suggested that shorter telomere length (TL) may be a risk factor for psychiatric disorders. However, whether this association underlie causal effects remains unknown. This study aims to investigate the potential association between TL and psychiatric disorders by conducting a bidirectional Mendelian randomization (MR) study. Summary statistics for TL were obtained from the UK Biobank (n = 472,174), while summary statistics for ten psychiatric disorders were acquired from the Psychiatric Genomics Consortium (PGC). The inverse-variance weighted (IVW) method was used as primary analysis, with the MR-Egger, weighted median, MR-PRESSO, simple mode, and weighted mode approaches were utilized as sensitivity analyses. Our findings indicated a potential association between genetic predisposition to attention deficit hyperactivity disorder (ADHD) and shortened TL (Beta = − 0.039, SE = 0.011, P = 4.00E-04). Additionally, posttraumatic stress disorder (PTSD) may be was potentially associated with TL (Beta = − 0.014, SE = 0.006, P = 0.019). Our findings suggest a potential correlation between ADHD and TL, yet no significant association exists between TL and other psychiatric disorders. Nevertheless, considering the small effect size and the fact that it might have limited practical clinical significance, TL may not function as a biomarker for psychiatric disorders. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Mendelian randomization
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      – TitleFull: Association between telomere length and psychiatric disorders: a bidirectional Mendelian randomization study.
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              Text: Jun2026
              Type: published
              Y: 2026
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