Anticonvulsant Use in Older Age Bipolar Disorder in a Global Sample from the Global Aging and Geriatric Experiments in Bipolar Disorder Project: Utilisation d'anticonvulsivants pour le traitement des troubles bipolaires du sujet âgé auprès d'un échantillon mondial provenant du projet GAGE-BD
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| Title: | Anticonvulsant Use in Older Age Bipolar Disorder in a Global Sample from the Global Aging and Geriatric Experiments in Bipolar Disorder Project: Utilisation d'anticonvulsivants pour le traitement des troubles bipolaires du sujet âgé auprès d'un échantillon mondial provenant du projet GAGE-BD |
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| Authors: | Bodenstein, Katie C. (AUTHOR), Lesage, Myriam (AUTHOR), Lavin, Paola (AUTHOR), Schouws, Sigfried (AUTHOR), Orhan, Melis (AUTHOR), Beunders, Alexandra (AUTHOR), Almeida, Osvaldo P. (AUTHOR), Altinbas, Kursat (AUTHOR), Balanzá-Martínez, Vicent (AUTHOR), Barbosa, Izabela G. (AUTHOR), Blumberg, Hilary P. (AUTHOR), Briggs, Farren B.S. (AUTHOR), Calkin, Cynthia V. (AUTHOR), Forlenza, Orestes V. (AUTHOR), Forester, Brent (AUTHOR), Gildengers, Ariel G. (AUTHOR), Haarman, Benno C.M. (AUTHOR), Hajek, Tomas (AUTHOR), Lafer, Beny (AUTHOR), Nunes, Paula V. (AUTHOR) |
| Source: | Canadian Journal of Psychiatry. Jul2026, Vol. 71 Issue 7, p489-497. 9p. |
| Subjects: | Anticonvulsants, Bipolar disorder, Cardiovascular diseases risk factors, Drug utilization, Clinical indications, Older people, Valproic acid |
| Abstract (English): | Background: Anticonvulsants are an essential treatment for bipolar disorder; however, there is relatively little known about their use in older age bipolar disorder (OABD). In this paper, which leverages a large international dataset, we aim to 1) describe the use of anticonvulsants in OABD compared to younger age bipolar disorder (YABD; ages <50 years old) and 2) explore any demographic/clinical correlates. Methods: A secondary analysis was conducted on the international data from the Global Aging and Geriatric Experiments in Bipolar Disorder project. The main objective was to report the prevalence of anticonvulsant use in OABD over 50 years old (mean age = 62.27) and the most prescribed anticonvulsant. Additional analysis explored any demographic and clinical correlates associated with anticonvulsant use. Generalized linear mixed models were used for this analysis. Results: Of the 2,691 participants with bipolar disorder who had anticonvulsant prescribing data, 34.4% (n = 926) used anticonvulsants at the time of study. Rates of anticonvulsant prescribing did not significantly differ between OABD and YABD groups (36.7% (n = 666) vs. 29.7% (n = 260)). Anticonvulsant prescribing patterns for OABD and YABD did not significantly differ, with valproate as the most prescribed anticonvulsant. OABD anticonvulsant users had less lithium use, more antidepressant use, more rapid cycling, more mood episodes and more cardiovascular comorbidities compared to nonusers. Conclusion: Anticonvulsant use was similar in OABD and YABD. A number of important clinical correlates of anticonvulsant use were identified. [ABSTRACT FROM AUTHOR] |
| Abstract (French): | Les anticonvulsivants sont un traitement essentiel contre le trouble bipolaire, mais leur utilisation pour traiter les troubles bipolaires du sujet âgé est relativement peu connue. Dans cet article, lequel s'appuie sur un vaste ensemble de données internationales, nous visons 1) à décrire l'utilisation des anticonvulsivants pour traiter les troubles bipolaires du sujet âgé par rapport à leur utilisation pour traiter les troubles bipolaires du sujet jeune (< 50 ans) et 2) à explorer toute corrélation démographique/clinique. Une analyse secondaire des données internationales tirées du projet Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) a été menée. L'objectif principal était de faire état de la prévalence de l'utilisation d'anticonvulsivants pour traiter les troubles bipolaires du sujet âgé chez les personnes de plus de 50 ans (âge moyen : 62,27 ans) et de l'anticonvulsivant le plus prescrit. Une analyse supplémentaire a permis d'examiner chaque corrélat démographique et clinique associé à l'utilisation d'anticonvulsivants. Des modèles linéaires mixtes généralisés ont été utilisés dans le cadre de cette analyse. Sur les 2 691 participants atteints de trouble bipolaire pour lesquels des données sur la prescription d'anticonvulsivants étaient disponibles, 34,4% (n = 926) prenaient des anticonvulsivants au moment de l'étude. Les taux de prescription d'anticonvulsivants ne différaient pas de façon significative entre les groupes de troubles bipolaires du sujet âgé et le groupe de troubles bipolaires du sujet jeune (36,7% [n = 666] contre 29,7% [n = 260]). Les modèles de prescription d'anticonvulsivants pour les troubles bipolaires du sujet âgé et les troubles bipolaires du sujet jeune ne différaient pas de façon significative, le valproate étant l'anticonvulsivant le plus prescrit. Les personnes atteintes de troubles bipolaires du sujet âgé qui prenaient des anticonvulsivants ont pris moins de lithium et plus d'antidépresseur, ont présenté des cycles plus rapides, davantage de fluctuations de l'humeur et davantage de maladies cardiovasculaires concomitantes par rapport à celles qui n'en prenaient pas. L'utilisation d'anticonvulsivants était similaire pour traiter les troubles bipolaires du sujet âgé et ceux du sujet jeune. Un certain nombre de corrélats cliniques importants de l'utilisation d'anticonvulsivants ont été définis. [ABSTRACT FROM AUTHOR] |
| Copyright of Canadian Journal of Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 194393514 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Anticonvulsant Use in Older Age Bipolar Disorder in a Global Sample from the Global Aging and Geriatric Experiments in Bipolar Disorder Project: Utilisation d'anticonvulsivants pour le traitement des troubles bipolaires du sujet âgé auprès d'un échantillon mondial provenant du projet GAGE-BD – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bodenstein%2C+Katie+C%2E%22">Bodenstein, Katie C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lesage%2C+Myriam%22">Lesage, Myriam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lavin%2C+Paola%22">Lavin, Paola</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schouws%2C+Sigfried%22">Schouws, Sigfried</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Orhan%2C+Melis%22">Orhan, Melis</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Beunders%2C+Alexandra%22">Beunders, Alexandra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Almeida%2C+Osvaldo+P%2E%22">Almeida, Osvaldo P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Altinbas%2C+Kursat%22">Altinbas, Kursat</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Balanzá-Martínez%2C+Vicent%22">Balanzá-Martínez, Vicent</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barbosa%2C+Izabela+G%2E%22">Barbosa, Izabela G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blumberg%2C+Hilary+P%2E%22">Blumberg, Hilary P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Briggs%2C+Farren+B%2ES%2E%22">Briggs, Farren B.S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Calkin%2C+Cynthia+V%2E%22">Calkin, Cynthia V.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Forlenza%2C+Orestes+V%2E%22">Forlenza, Orestes V.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Forester%2C+Brent%22">Forester, Brent</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gildengers%2C+Ariel+G%2E%22">Gildengers, Ariel G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Haarman%2C+Benno+C%2EM%2E%22">Haarman, Benno C.M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hajek%2C+Tomas%22">Hajek, Tomas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lafer%2C+Beny%22">Lafer, Beny</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nunes%2C+Paula+V%2E%22">Nunes, Paula V.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Canadian+Journal+of+Psychiatry%22">Canadian Journal of Psychiatry</searchLink>. Jul2026, Vol. 71 Issue 7, p489-497. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Anticonvulsants%22">Anticonvulsants</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiovascular+diseases+risk+factors%22">Cardiovascular diseases risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+utilization%22">Drug utilization</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+indications%22">Clinical indications</searchLink><br /><searchLink fieldCode="DE" term="%22Older+people%22">Older people</searchLink><br /><searchLink fieldCode="DE" term="%22Valproic+acid%22">Valproic acid</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Background: Anticonvulsants are an essential treatment for bipolar disorder; however, there is relatively little known about their use in older age bipolar disorder (OABD). In this paper, which leverages a large international dataset, we aim to 1) describe the use of anticonvulsants in OABD compared to younger age bipolar disorder (YABD; ages <50 years old) and 2) explore any demographic/clinical correlates. Methods: A secondary analysis was conducted on the international data from the Global Aging and Geriatric Experiments in Bipolar Disorder project. The main objective was to report the prevalence of anticonvulsant use in OABD over 50 years old (mean age = 62.27) and the most prescribed anticonvulsant. Additional analysis explored any demographic and clinical correlates associated with anticonvulsant use. Generalized linear mixed models were used for this analysis. Results: Of the 2,691 participants with bipolar disorder who had anticonvulsant prescribing data, 34.4% (n = 926) used anticonvulsants at the time of study. Rates of anticonvulsant prescribing did not significantly differ between OABD and YABD groups (36.7% (n = 666) vs. 29.7% (n = 260)). Anticonvulsant prescribing patterns for OABD and YABD did not significantly differ, with valproate as the most prescribed anticonvulsant. OABD anticonvulsant users had less lithium use, more antidepressant use, more rapid cycling, more mood episodes and more cardiovascular comorbidities compared to nonusers. Conclusion: Anticonvulsant use was similar in OABD and YABD. A number of important clinical correlates of anticonvulsant use were identified. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (French) Group: Ab Data: Les anticonvulsivants sont un traitement essentiel contre le trouble bipolaire, mais leur utilisation pour traiter les troubles bipolaires du sujet âgé est relativement peu connue. Dans cet article, lequel s'appuie sur un vaste ensemble de données internationales, nous visons 1) à décrire l'utilisation des anticonvulsivants pour traiter les troubles bipolaires du sujet âgé par rapport à leur utilisation pour traiter les troubles bipolaires du sujet jeune (< 50 ans) et 2) à explorer toute corrélation démographique/clinique. Une analyse secondaire des données internationales tirées du projet Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) a été menée. L'objectif principal était de faire état de la prévalence de l'utilisation d'anticonvulsivants pour traiter les troubles bipolaires du sujet âgé chez les personnes de plus de 50 ans (âge moyen : 62,27 ans) et de l'anticonvulsivant le plus prescrit. Une analyse supplémentaire a permis d'examiner chaque corrélat démographique et clinique associé à l'utilisation d'anticonvulsivants. Des modèles linéaires mixtes généralisés ont été utilisés dans le cadre de cette analyse. Sur les 2 691 participants atteints de trouble bipolaire pour lesquels des données sur la prescription d'anticonvulsivants étaient disponibles, 34,4% (n = 926) prenaient des anticonvulsivants au moment de l'étude. Les taux de prescription d'anticonvulsivants ne différaient pas de façon significative entre les groupes de troubles bipolaires du sujet âgé et le groupe de troubles bipolaires du sujet jeune (36,7% [n = 666] contre 29,7% [n = 260]). Les modèles de prescription d'anticonvulsivants pour les troubles bipolaires du sujet âgé et les troubles bipolaires du sujet jeune ne différaient pas de façon significative, le valproate étant l'anticonvulsivant le plus prescrit. Les personnes atteintes de troubles bipolaires du sujet âgé qui prenaient des anticonvulsivants ont pris moins de lithium et plus d'antidépresseur, ont présenté des cycles plus rapides, davantage de fluctuations de l'humeur et davantage de maladies cardiovasculaires concomitantes par rapport à celles qui n'en prenaient pas. L'utilisation d'anticonvulsivants était similaire pour traiter les troubles bipolaires du sujet âgé et ceux du sujet jeune. Un certain nombre de corrélats cliniques importants de l'utilisation d'anticonvulsivants ont été définis. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Canadian Journal of Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1177/07067437251372190 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 489 Subjects: – SubjectFull: Anticonvulsants Type: general – SubjectFull: Bipolar disorder Type: general – SubjectFull: Cardiovascular diseases risk factors Type: general – SubjectFull: Drug utilization Type: general – SubjectFull: Clinical indications Type: general – SubjectFull: Older people Type: general – SubjectFull: Valproic acid Type: general Titles: – TitleFull: Anticonvulsant Use in Older Age Bipolar Disorder in a Global Sample from the Global Aging and Geriatric Experiments in Bipolar Disorder Project: Utilisation d'anticonvulsivants pour le traitement des troubles bipolaires du sujet âgé auprès d'un échantillon mondial provenant du projet GAGE-BD Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bodenstein, Katie C. – PersonEntity: Name: NameFull: Lesage, Myriam – PersonEntity: Name: NameFull: Lavin, Paola – PersonEntity: Name: NameFull: Schouws, Sigfried – PersonEntity: Name: NameFull: Orhan, Melis – PersonEntity: Name: NameFull: Beunders, Alexandra – PersonEntity: Name: NameFull: Almeida, Osvaldo P. – PersonEntity: Name: NameFull: Altinbas, Kursat – PersonEntity: Name: NameFull: Balanzá-Martínez, Vicent – PersonEntity: Name: NameFull: Barbosa, Izabela G. – PersonEntity: Name: NameFull: Blumberg, Hilary P. – PersonEntity: Name: NameFull: Briggs, Farren B.S. – PersonEntity: Name: NameFull: Calkin, Cynthia V. – PersonEntity: Name: NameFull: Forlenza, Orestes V. – PersonEntity: Name: NameFull: Forester, Brent – PersonEntity: Name: NameFull: Gildengers, Ariel G. – PersonEntity: Name: NameFull: Haarman, Benno C.M. – PersonEntity: Name: NameFull: Hajek, Tomas – PersonEntity: Name: NameFull: Lafer, Beny – PersonEntity: Name: NameFull: Nunes, Paula V. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 07067437 Numbering: – Type: volume Value: 71 – Type: issue Value: 7 Titles: – TitleFull: Canadian Journal of Psychiatry Type: main |
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