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Distinct Trajectories of Amygdala Connectivity Patterns Characterize Remission vs. Non‐Remission in Patients With Major Depressive Disorder.

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Title: Distinct Trajectories of Amygdala Connectivity Patterns Characterize Remission vs. Non‐Remission in Patients With Major Depressive Disorder.
Authors: Zhang, Shudong (AUTHOR), Zhang, Zhifang (AUTHOR), Li, Xiaoya (AUTHOR), Zhou, Jingjing (AUTHOR), Li, Ruinan (AUTHOR), Liu, Rui (AUTHOR), Wang, Yun (AUTHOR), Chen, Xiongying (AUTHOR), Feng, Yuan (AUTHOR), Cui, Jian (AUTHOR), Zhang, Ling (AUTHOR), Zhou, Yuan (AUTHOR), Wang, Gang (AUTHOR), Bose, Chandra (AUTHOR)
Source: Depression & Anxiety (1091-4269). 6/11/2026, Vol. 2026, p1-13. 13p.
Subjects: Functional connectivity, Disease remission, Neural pathways, Functional magnetic resonance imaging, Longitudinal method, Mental depression, Antidepressants
Abstract: Background: This study aimed to investigate the neural basis of individual differences in antidepressant efficacy using an 8‐week longitudinal multitime point resting‐state functional magnetic resonance imaging (fMRI) design. Methods: Forty‐eight patients with major depressive disorder (MDD) completed two or three scans, and 44 healthy controls (HCs) underwent a baseline scan. Patients were categorized into remission (MDDr) and nonremission (MDDnr) groups based on treatment outcomes. Group differences in resting‐state functional connectivity (rsFC) of the amygdala subregions at baseline were examined among MDDr, MDDnr, and HCs. Longitudinal changes in the identified rsFC were compared between the MDDr and MDDnr groups. Correlation analyses were conducted to explore the relationship between baseline rsFC or its longitudinal changes and depressive symptom severity or improvement. Results: At baseline, rsFC between the right basolateral (BL) amygdala and the right supplementary motor area (SMA) was lower in the MDDr group but higher in the MDDnr group compared with HCs, although this effect did not survive multiple comparisons correction across amygdala subregions. The trajectory of this rsFC differed between the two patient groups during treatment, with normalization observed at 2 and 8 weeks posttreatment. Correlation analyses indicated that baseline rsFC was associated with treatment response and that longitudinal changes in rsFC were aligned with symptom improvement, although some associations did not survive multiple comparisons correction. Conclusions: Our findings provide novel and valuable insights into the neural mechanisms underlying antidepressant response and highlight the role of amygdala subregional connectivity in explaining interindividual variability in treatment efficacy. Trial Registration: ClinicalTrials.gov identifier: ChiCTR2400093823 [ABSTRACT FROM AUTHOR]
Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Distinct Trajectories of Amygdala Connectivity Patterns Characterize Remission vs. Non‐Remission in Patients With Major Depressive Disorder.
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  Data: <searchLink fieldCode="AR" term="%22Zhang%2C+Shudong%22">Zhang, Shudong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Zhifang%22">Zhang, Zhifang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Xiaoya%22">Li, Xiaoya</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Jingjing%22">Zhou, Jingjing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Ruinan%22">Li, Ruinan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Rui%22">Liu, Rui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Yun%22">Wang, Yun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Xiongying%22">Chen, Xiongying</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Feng%2C+Yuan%22">Feng, Yuan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cui%2C+Jian%22">Cui, Jian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Ling%22">Zhang, Ling</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Yuan%22">Zhou, Yuan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Gang%22">Wang, Gang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bose%2C+Chandra%22">Bose, Chandra</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Depression+%26+Anxiety+%281091-4269%29%22">Depression & Anxiety (1091-4269)</searchLink>. 6/11/2026, Vol. 2026, p1-13. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Functional+connectivity%22">Functional connectivity</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+remission%22">Disease remission</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+pathways%22">Neural pathways</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: This study aimed to investigate the neural basis of individual differences in antidepressant efficacy using an 8‐week longitudinal multitime point resting‐state functional magnetic resonance imaging (fMRI) design. Methods: Forty‐eight patients with major depressive disorder (MDD) completed two or three scans, and 44 healthy controls (HCs) underwent a baseline scan. Patients were categorized into remission (MDDr) and nonremission (MDDnr) groups based on treatment outcomes. Group differences in resting‐state functional connectivity (rsFC) of the amygdala subregions at baseline were examined among MDDr, MDDnr, and HCs. Longitudinal changes in the identified rsFC were compared between the MDDr and MDDnr groups. Correlation analyses were conducted to explore the relationship between baseline rsFC or its longitudinal changes and depressive symptom severity or improvement. Results: At baseline, rsFC between the right basolateral (BL) amygdala and the right supplementary motor area (SMA) was lower in the MDDr group but higher in the MDDnr group compared with HCs, although this effect did not survive multiple comparisons correction across amygdala subregions. The trajectory of this rsFC differed between the two patient groups during treatment, with normalization observed at 2 and 8 weeks posttreatment. Correlation analyses indicated that baseline rsFC was associated with treatment response and that longitudinal changes in rsFC were aligned with symptom improvement, although some associations did not survive multiple comparisons correction. Conclusions: Our findings provide novel and valuable insights into the neural mechanisms underlying antidepressant response and highlight the role of amygdala subregional connectivity in explaining interindividual variability in treatment efficacy. Trial Registration: ClinicalTrials.gov identifier: ChiCTR2400093823 [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1155/da/4701907
    Languages:
      – Code: eng
        Text: English
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        PageCount: 13
        StartPage: 1
    Subjects:
      – SubjectFull: Functional connectivity
        Type: general
      – SubjectFull: Disease remission
        Type: general
      – SubjectFull: Neural pathways
        Type: general
      – SubjectFull: Functional magnetic resonance imaging
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Antidepressants
        Type: general
    Titles:
      – TitleFull: Distinct Trajectories of Amygdala Connectivity Patterns Characterize Remission vs. Non‐Remission in Patients With Major Depressive Disorder.
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              M: 06
              Text: 6/11/2026
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              Y: 2026
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