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Suicide Risk Among Transgender Adolescents and Young Adults: A Meta‐Analysis of Nearly One Million Participants.

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Title: Suicide Risk Among Transgender Adolescents and Young Adults: A Meta‐Analysis of Nearly One Million Participants.
Authors: Hassan, Noheir Ashraf Ibrahem Fathy (AUTHOR), Toraih, Eman A. (AUTHOR), Shebl, Menna A. (AUTHOR), Usmani, Amaan (AUTHOR), Atwal, Uday (AUTHOR), Laraib‐Ijaz, Ayesha (AUTHOR), Samuel, Helen A. O. (AUTHOR), Eldessouky, Ahmed Ibrahim (AUTHOR), Alhouli, Anwar (AUTHOR), Elsawah, Yusuf (AUTHOR), Sunny, Sonnet (AUTHOR), Aslam, Muaaz (AUTHOR), Shah, Jaafer (AUTHOR), Hazimeh, Yusef (AUTHOR), Aiash, Hani (AUTHOR)
Source: International Journal of Methods in Psychiatric Research. Jun2026, Vol. 35 Issue 2, p1-15. 15p.
Subjects: Transgender youth, Suicidal ideation, Young adults, Evidence synthesis, Mental health, Suicide risk factors, Attempted suicide, Public health
Abstract: Background: Mental health disparities among transgender and gender diverse adolescents and young adults represent a critical public health concern. This meta‐analysis examined suicidal risk among transgender youth compared to their cisgender peers. Methods: Following PRISMA guidelines, we analyzed 29 studies published between 2015–2024, comprising nearly one million participants (957,163; 29,041 transgender and 928,122 cisgender). Random effects models were used to calculate risk ratios (RR) and prevalence estimates for suicidal ideation, planning, attempts, and completion. Results: Transgender youth showed significantly higher prevalence of suicidal ideation (transmale: 52.2%, transfemale: 49.5% vs. cismale: 18.1%, cisfemale: 22.4%; p < 0.001) and attempts (48.0%–51.3% vs. 18.0%–22.0%; p < 0.001). Risk analyses revealed elevated risks for ideation (RR = 2.38, 95% CI: 1.97–2.88), attempts (RR = 2.85, 95% CI: 1.31–6.21), and completed suicide (RR = 4.80, 95% CI: 2.15–10.74). However, substantial heterogeneity was observed across all suicide outcomes (I2 > 90%), indicating that pooled estimates should be interpreted with caution. Publication bias assessment suggested potential overestimation of unadjusted effects, with trim‐and‐fill adjustment reducing the pooled risk estimate (adjusted RR = 1.25, 95% CI: 1.08–1.45). No significant differences emerged between transmale and transfemale groups (p > 0.05). Conclusion: Overall, this meta‐analysis documents markedly elevated suicidality among transgender adolescents and young adults, while emphasizing the need for cautious interpretation of aggregated effect sizes and further high‐quality longitudinal research. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Methods in Psychiatric Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Suicide Risk Among Transgender Adolescents and Young Adults: A Meta‐Analysis of Nearly One Million Participants.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hassan%2C+Noheir+Ashraf+Ibrahem+Fathy%22&quot;&gt;Hassan, Noheir Ashraf Ibrahem Fathy&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Toraih%2C+Eman+A%2E%22&quot;&gt;Toraih, Eman A.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shebl%2C+Menna+A%2E%22&quot;&gt;Shebl, Menna A.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Usmani%2C+Amaan%22&quot;&gt;Usmani, Amaan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Atwal%2C+Uday%22&quot;&gt;Atwal, Uday&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Laraib‐Ijaz%2C+Ayesha%22&quot;&gt;Laraib‐Ijaz, Ayesha&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Samuel%2C+Helen+A%2E+O%2E%22&quot;&gt;Samuel, Helen A. O.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Eldessouky%2C+Ahmed+Ibrahim%22&quot;&gt;Eldessouky, Ahmed Ibrahim&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Alhouli%2C+Anwar%22&quot;&gt;Alhouli, Anwar&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Elsawah%2C+Yusuf%22&quot;&gt;Elsawah, Yusuf&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sunny%2C+Sonnet%22&quot;&gt;Sunny, Sonnet&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Aslam%2C+Muaaz%22&quot;&gt;Aslam, Muaaz&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shah%2C+Jaafer%22&quot;&gt;Shah, Jaafer&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hazimeh%2C+Yusef%22&quot;&gt;Hazimeh, Yusef&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Aiash%2C+Hani%22&quot;&gt;Aiash, Hani&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22International+Journal+of+Methods+in+Psychiatric+Research%22&quot;&gt;International Journal of Methods in Psychiatric Research&lt;/searchLink&gt;. Jun2026, Vol. 35 Issue 2, p1-15. 15p.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Mental health disparities among transgender and gender diverse adolescents and young adults represent a critical public health concern. This meta‐analysis examined suicidal risk among transgender youth compared to their cisgender peers. Methods: Following PRISMA guidelines, we analyzed 29 studies published between 2015–2024, comprising nearly one million participants (957,163; 29,041 transgender and 928,122 cisgender). Random effects models were used to calculate risk ratios (RR) and prevalence estimates for suicidal ideation, planning, attempts, and completion. Results: Transgender youth showed significantly higher prevalence of suicidal ideation (transmale: 52.2%, transfemale: 49.5% vs. cismale: 18.1%, cisfemale: 22.4%; p &lt; 0.001) and attempts (48.0%–51.3% vs. 18.0%–22.0%; p &lt; 0.001). Risk analyses revealed elevated risks for ideation (RR = 2.38, 95% CI: 1.97–2.88), attempts (RR = 2.85, 95% CI: 1.31–6.21), and completed suicide (RR = 4.80, 95% CI: 2.15–10.74). However, substantial heterogeneity was observed across all suicide outcomes (I2 &gt; 90%), indicating that pooled estimates should be interpreted with caution. Publication bias assessment suggested potential overestimation of unadjusted effects, with trim‐and‐fill adjustment reducing the pooled risk estimate (adjusted RR = 1.25, 95% CI: 1.08–1.45). No significant differences emerged between transmale and transfemale groups (p &gt; 0.05). Conclusion: Overall, this meta‐analysis documents markedly elevated suicidality among transgender adolescents and young adults, while emphasizing the need for cautious interpretation of aggregated effect sizes and further high‐quality longitudinal research. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of International Journal of Methods in Psychiatric Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1002/mpr.70077
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 15
        StartPage: 1
    Subjects:
      – SubjectFull: Transgender youth
        Type: general
      – SubjectFull: Suicidal ideation
        Type: general
      – SubjectFull: Young adults
        Type: general
      – SubjectFull: Evidence synthesis
        Type: general
      – SubjectFull: Mental health
        Type: general
      – SubjectFull: Suicide risk factors
        Type: general
      – SubjectFull: Attempted suicide
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      – SubjectFull: Public health
        Type: general
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      – TitleFull: Suicide Risk Among Transgender Adolescents and Young Adults: A Meta‐Analysis of Nearly One Million Participants.
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              M: 06
              Text: Jun2026
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