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Social and Clinical Factors Associated With Antipsychotic Medication Discontinuation in Patients With Schizophrenia.

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Title: Social and Clinical Factors Associated With Antipsychotic Medication Discontinuation in Patients With Schizophrenia.
Authors: Chen, Zhengquan (AUTHOR), Wu, Yiming (AUTHOR), Wang, Zuowei (AUTHOR), Wang, Jun (AUTHOR), Jiang, Chao (AUTHOR), Shen, Wenchao (AUTHOR), Zheng, Yanting (AUTHOR), Wu, Yi (AUTHOR)
Source: International Journal of Methods in Psychiatric Research. Jun2026, Vol. 35 Issue 2, p1-9. 9p.
Subjects: Termination of treatment, Antipsychotic agents, Schizophrenia, Social skills, Disease risk factors, Social factors, Symptom burden, Cognitive ability
Abstract: Objectives: This study aims to identify social and clinical factors associated with antipsychotic medication discontinuation in patients with schizophrenia. Methods: This cross‐sectional case‐control study comprised 111 schizophrenia patients, including 55 who discontinued medication on their own initiative and 56 matched continuous‐treatment patients. Assessed factors covered demographics, clinical profiles, and scores from the Positive and Negative Syndrome Scale (PANSS), the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and the Personal and Social Performance (PSP) scale. Results: Patients in the discontinuation group demonstrated significantly higher employment rates (χ2 = 24.514, p < 0.001) and marriage rates (χ2 = 14.970, p = 0.002) compared to those in the continuous treatment group. The continuous treatment group had more episodes (p < 0.001) and severe symptoms (PANSS, p < 0.001) with lower cognitive (RBANS, p = 0.001) and social functioning scores (PSP, p < 0.001) compared to the discontinuation group. Regression analysis revealed that fewer episodes (β = 2.799, p = 0.018) and lower PANSS negative symptom scores (β = 0.533, p = 0.011) were associated with a greater likelihood of medication discontinuation. Conclusion: The discontinuation group exhibited milder schizophrenia symptoms and higher social functioning than the continuation group. Furthermore, patients with fewer episodes and milder negative symptoms were more likely to discontinue medication. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Methods in Psychiatric Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Social and Clinical Factors Associated With Antipsychotic Medication Discontinuation in Patients With Schizophrenia.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chen%2C+Zhengquan%22&quot;&gt;Chen, Zhengquan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wu%2C+Yiming%22&quot;&gt;Wu, Yiming&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wang%2C+Zuowei%22&quot;&gt;Wang, Zuowei&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wang%2C+Jun%22&quot;&gt;Wang, Jun&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jiang%2C+Chao%22&quot;&gt;Jiang, Chao&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shen%2C+Wenchao%22&quot;&gt;Shen, Wenchao&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zheng%2C+Yanting%22&quot;&gt;Zheng, Yanting&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wu%2C+Yi%22&quot;&gt;Wu, Yi&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22International+Journal+of+Methods+in+Psychiatric+Research%22&quot;&gt;International Journal of Methods in Psychiatric Research&lt;/searchLink&gt;. Jun2026, Vol. 35 Issue 2, p1-9. 9p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Termination+of+treatment%22&quot;&gt;Termination of treatment&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Antipsychotic+agents%22&quot;&gt;Antipsychotic agents&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Schizophrenia%22&quot;&gt;Schizophrenia&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Social+skills%22&quot;&gt;Social skills&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Disease+risk+factors%22&quot;&gt;Disease risk factors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Social+factors%22&quot;&gt;Social factors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Symptom+burden%22&quot;&gt;Symptom burden&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cognitive+ability%22&quot;&gt;Cognitive ability&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: This study aims to identify social and clinical factors associated with antipsychotic medication discontinuation in patients with schizophrenia. Methods: This cross‐sectional case‐control study comprised 111 schizophrenia patients, including 55 who discontinued medication on their own initiative and 56 matched continuous‐treatment patients. Assessed factors covered demographics, clinical profiles, and scores from the Positive and Negative Syndrome Scale (PANSS), the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and the Personal and Social Performance (PSP) scale. Results: Patients in the discontinuation group demonstrated significantly higher employment rates (χ2 = 24.514, p &lt; 0.001) and marriage rates (χ2 = 14.970, p = 0.002) compared to those in the continuous treatment group. The continuous treatment group had more episodes (p &lt; 0.001) and severe symptoms (PANSS, p &lt; 0.001) with lower cognitive (RBANS, p = 0.001) and social functioning scores (PSP, p &lt; 0.001) compared to the discontinuation group. Regression analysis revealed that fewer episodes (β = 2.799, p = 0.018) and lower PANSS negative symptom scores (β = 0.533, p = 0.011) were associated with a greater likelihood of medication discontinuation. Conclusion: The discontinuation group exhibited milder schizophrenia symptoms and higher social functioning than the continuation group. Furthermore, patients with fewer episodes and milder negative symptoms were more likely to discontinue medication. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of International Journal of Methods in Psychiatric Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1002/mpr.70082
    Languages:
      – Code: eng
        Text: English
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        PageCount: 9
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    Subjects:
      – SubjectFull: Termination of treatment
        Type: general
      – SubjectFull: Antipsychotic agents
        Type: general
      – SubjectFull: Schizophrenia
        Type: general
      – SubjectFull: Social skills
        Type: general
      – SubjectFull: Disease risk factors
        Type: general
      – SubjectFull: Social factors
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      – SubjectFull: Symptom burden
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      – SubjectFull: Cognitive ability
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      – TitleFull: Social and Clinical Factors Associated With Antipsychotic Medication Discontinuation in Patients With Schizophrenia.
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              Text: Jun2026
              Type: published
              Y: 2026
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