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Olanzapine plasma level in relation to antimanic effect in the acute therapy of manic states.

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Title: Olanzapine plasma level in relation to antimanic effect in the acute therapy of manic states.
Authors: Bech, P. (AUTHOR), Gex-Fabry, M. (AUTHOR), Aubry, J.-M. (AUTHOR), Favre, S. (AUTHOR), Bertschy, G. (AUTHOR)
Source: Nordic Journal of Psychiatry. Apr2006, Vol. 60 Issue 2, p181-182. 2p. 1 Chart.
Subjects: Mania, Bipolar disorder, Olanzapine, Psychological tests, Scale analysis (Psychology), Psychometrics
Abstract: The aim of this study was to evaluate internal as well as external validity of the two most frequently used mania scales, the Young Mania Rating Scale (YMRS) and the Bech–Rafaelsen Mania Scale (MAS), in patients with DSM-IV mania. Mokken analysis was used to evaluate internal validity in which a coefficient of homogeneity of 0.40 or higher indicates that the total score is a sufficient statistic. The external validity was evaluated by plasma-level relationship of olanzapine. In total, 20 patients with DSM-IV mania were analysed, and the coefficient of homogeneity was acceptable for the MAS, but not for the YMRS. In a subgroup of females who over 2  weeks had received a fixed dose of 20  mg olanzapine daily, a significant association was found between MAS scores and plasma levels, but this association was not obtained with the YMRS. In conclusion, the MAS was found superior to the YMRS in regard to both internal and external validity. [ABSTRACT FROM AUTHOR]
Copyright of Nordic Journal of Psychiatry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Olanzapine plasma level in relation to antimanic effect in the acute therapy of manic states.
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  Data: <searchLink fieldCode="AR" term="%22Bech%2C+P%2E%22">Bech, P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gex-Fabry%2C+M%2E%22">Gex-Fabry, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aubry%2C+J%2E-M%2E%22">Aubry, J.-M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Favre%2C+S%2E%22">Favre, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bertschy%2C+G%2E%22">Bertschy, G.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Nordic+Journal+of+Psychiatry%22">Nordic Journal of Psychiatry</searchLink>. Apr2006, Vol. 60 Issue 2, p181-182. 2p. 1 Chart.
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  Data: <searchLink fieldCode="DE" term="%22Mania%22">Mania</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Olanzapine%22">Olanzapine</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+tests%22">Psychological tests</searchLink><br /><searchLink fieldCode="DE" term="%22Scale+analysis+%28Psychology%29%22">Scale analysis (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Psychometrics%22">Psychometrics</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: The aim of this study was to evaluate internal as well as external validity of the two most frequently used mania scales, the Young Mania Rating Scale (YMRS) and the Bech–Rafaelsen Mania Scale (MAS), in patients with DSM-IV mania. Mokken analysis was used to evaluate internal validity in which a coefficient of homogeneity of 0.40 or higher indicates that the total score is a sufficient statistic. The external validity was evaluated by plasma-level relationship of olanzapine. In total, 20 patients with DSM-IV mania were analysed, and the coefficient of homogeneity was acceptable for the MAS, but not for the YMRS. In a subgroup of females who over 2  weeks had received a fixed dose of 20  mg olanzapine daily, a significant association was found between MAS scores and plasma levels, but this association was not obtained with the YMRS. In conclusion, the MAS was found superior to the YMRS in regard to both internal and external validity. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Nordic Journal of Psychiatry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/08039480600601282
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        Text: English
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              Text: Apr2006
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