Genetic dissociation of two behaviors associated with nicotine addiction: Beta-2 containing nicotinic receptors are involved in nicotine reinforcement but not in withdrawal syndrome.
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| Title: | Genetic dissociation of two behaviors associated with nicotine addiction: Beta-2 containing nicotinic receptors are involved in nicotine reinforcement but not in withdrawal syndrome. |
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| Authors: | Besson, M., David, V., Suarez, S., Cormier, A., Cazala, P., Changeux, J. -P., Granon, S. |
| Source: | Psychopharmacology. Aug2006, Vol. 187 Issue 2, p189-199. 11p. 1 Color Photograph, 1 Chart, 3 Graphs. |
| Subjects: | Nicotine addiction, Nicotinic receptors, Cholinergic receptors, Drug withdrawal symptoms, Mice |
| Abstract: | Rationale Nicotine addiction is characterized by two distinct behaviors, chronic compulsive self-administration and the induction of a withdrawal syndrome upon cessation of nicotine consumption. Objective To examine if these two processes rely on β2-containing nicotinic receptors--β2*nAChRs--we analyzed the behavior of mice lacking these receptors in the two situations. Results First, we showed that, in contrast to wild-type (WT) mice, β2-knockout (β2-/-) mice exhibit no intra-ventral tegmental area (VTA) nicotine self-administration, whereas their ability to self-administer morphine is intact. However, β2-/- mice showed some sensitivity to locomotor effects of nicotine, implying an effect of the drug on other nicotinic subtypes. Then, we observed that β2-/- mice exhibited a normal nicotine withdrawal syndrome, i.e., increased levels of rearing and jumping upon precipitated withdrawal. Thus, the β2*nAChRs are not involved in the behaviors induced by cessation of nicotine consumption. Conclusion Taken together, the present data demonstrated a genetic dissociation of two distinct behavioral patterns associated with nicotine addiction. They further suggested that independent molecular mechanisms underlie these two aspects, offering the possibility of controlling them separately. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 21467313 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Genetic dissociation of two behaviors associated with nicotine addiction: Beta-2 containing nicotinic receptors are involved in nicotine reinforcement but not in withdrawal syndrome. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Besson%2C+M%2E%22">Besson, M.</searchLink><br /><searchLink fieldCode="AR" term="%22David%2C+V%2E%22">David, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Suarez%2C+S%2E%22">Suarez, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Cormier%2C+A%2E%22">Cormier, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Cazala%2C+P%2E%22">Cazala, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Changeux%2C+J%2E+-P%2E%22">Changeux, J. -P.</searchLink><br /><searchLink fieldCode="AR" term="%22Granon%2C+S%2E%22">Granon, S.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Aug2006, Vol. 187 Issue 2, p189-199. 11p. 1 Color Photograph, 1 Chart, 3 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Nicotine+addiction%22">Nicotine addiction</searchLink><br /><searchLink fieldCode="DE" term="%22Nicotinic+receptors%22">Nicotinic receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Cholinergic+receptors%22">Cholinergic receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+withdrawal+symptoms%22">Drug withdrawal symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%22">Mice</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale Nicotine addiction is characterized by two distinct behaviors, chronic compulsive self-administration and the induction of a withdrawal syndrome upon cessation of nicotine consumption. Objective To examine if these two processes rely on β2-containing nicotinic receptors--β2*nAChRs--we analyzed the behavior of mice lacking these receptors in the two situations. Results First, we showed that, in contrast to wild-type (WT) mice, β2-knockout (β2-/-) mice exhibit no intra-ventral tegmental area (VTA) nicotine self-administration, whereas their ability to self-administer morphine is intact. However, β2-/- mice showed some sensitivity to locomotor effects of nicotine, implying an effect of the drug on other nicotinic subtypes. Then, we observed that β2-/- mice exhibited a normal nicotine withdrawal syndrome, i.e., increased levels of rearing and jumping upon precipitated withdrawal. Thus, the β2*nAChRs are not involved in the behaviors induced by cessation of nicotine consumption. Conclusion Taken together, the present data demonstrated a genetic dissociation of two distinct behavioral patterns associated with nicotine addiction. They further suggested that independent molecular mechanisms underlie these two aspects, offering the possibility of controlling them separately. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-006-0418-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 189 Subjects: – SubjectFull: Nicotine addiction Type: general – SubjectFull: Nicotinic receptors Type: general – SubjectFull: Cholinergic receptors Type: general – SubjectFull: Drug withdrawal symptoms Type: general – SubjectFull: Mice Type: general Titles: – TitleFull: Genetic dissociation of two behaviors associated with nicotine addiction: Beta-2 containing nicotinic receptors are involved in nicotine reinforcement but not in withdrawal syndrome. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Besson, M. – PersonEntity: Name: NameFull: David, V. – PersonEntity: Name: NameFull: Suarez, S. – PersonEntity: Name: NameFull: Cormier, A. – PersonEntity: Name: NameFull: Cazala, P. – PersonEntity: Name: NameFull: Changeux, J. -P. – PersonEntity: Name: NameFull: Granon, S. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 187 – Type: issue Value: 2 Titles: – TitleFull: Psychopharmacology Type: main |
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