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Increased intracerebral cerebrospinal fluid spaces predict unemployment and negative symptoms in psychotic illness. A prospective study.

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Title: Increased intracerebral cerebrospinal fluid spaces predict unemployment and negative symptoms in psychotic illness. A prospective study.
Authors: Van Os, Jim, Fahy, Thomas A., Jones, Peter, Harvey, Ian, Lewis, Shôn, Williams, Maureen, Toone, Brian, Murray, Robin, van Os, J (AUTHOR), Fahy, T A (AUTHOR), Jones, P (AUTHOR), Harvey, I (AUTHOR), Lewis, S (AUTHOR), Williams, M (AUTHOR), Toone, B (AUTHOR), Murray, R (AUTHOR)
Source: British Journal of Psychiatry. Jun95, Vol. 166, p750-758. 9p.
Subjects: Cerebrospinal fluid, Psychoses, Pathological psychology, Mental illness, Cerebral ventricles, Suicide & psychology, Unemployment & psychology, Vocational rehabilitation, Arousal (Physiology), Computed tomography, Longitudinal method, Prognosis, Psychological tests, Treatment effectiveness, Psychology
Abstract: Background: It has been suggested that the dimensions of cerebral ventricles are a risk factor for poor outcome in psychotic illness.Method: A cohort of 140 patients with functional psychoses of recent onset who had undergone CT scanning, were followed up for an average of 46 months and assessed on six dimensions of course and outcome of illness.Results: Left and right sylvian fissure volumes and, to a lesser extent, third ventricular volume predicted negative symptoms and unemployment over the course of follow-up, the latter association being mediated by poor cognitive functioning. There was significant linear trend in risk over the distribution of sylvian fissure volumes in the cohort, and associations were especially evident in schizophrenic patients. No associations were found with global severity of illness, duration of hospital stay, homelessness, or affective symptoms.Conclusions: These findings support the notion that dimensions of the cerebral ventricles are a continuous risk factor for some measures of outcome in the functional psychoses. [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Increased intracerebral cerebrospinal fluid spaces predict unemployment and negative symptoms in psychotic illness. A prospective study.
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  Data: <searchLink fieldCode="AR" term="%22Van+Os%2C+Jim%22">Van Os, Jim</searchLink><br /><searchLink fieldCode="AR" term="%22Fahy%2C+Thomas+A%2E%22">Fahy, Thomas A.</searchLink><br /><searchLink fieldCode="AR" term="%22Jones%2C+Peter%22">Jones, Peter</searchLink><br /><searchLink fieldCode="AR" term="%22Harvey%2C+Ian%22">Harvey, Ian</searchLink><br /><searchLink fieldCode="AR" term="%22Lewis%2C+Shôn%22">Lewis, Shôn</searchLink><br /><searchLink fieldCode="AR" term="%22Williams%2C+Maureen%22">Williams, Maureen</searchLink><br /><searchLink fieldCode="AR" term="%22Toone%2C+Brian%22">Toone, Brian</searchLink><br /><searchLink fieldCode="AR" term="%22Murray%2C+Robin%22">Murray, Robin</searchLink><br /><searchLink fieldCode="AR" term="%22van+Os%2C+J%22">van Os, J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fahy%2C+T+A%22">Fahy, T A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jones%2C+P%22">Jones, P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Harvey%2C+I%22">Harvey, I</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lewis%2C+S%22">Lewis, S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Williams%2C+M%22">Williams, M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Toone%2C+B%22">Toone, B</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Murray%2C+R%22">Murray, R</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22British+Journal+of+Psychiatry%22">British Journal of Psychiatry</searchLink>. Jun95, Vol. 166, p750-758. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Cerebrospinal+fluid%22">Cerebrospinal fluid</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+illness%22">Mental illness</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+ventricles%22">Cerebral ventricles</searchLink><br /><searchLink fieldCode="DE" term="%22Suicide+%26+psychology%22">Suicide & psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Unemployment+%26+psychology%22">Unemployment & psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Vocational+rehabilitation%22">Vocational rehabilitation</searchLink><br /><searchLink fieldCode="DE" term="%22Arousal+%28Physiology%29%22">Arousal (Physiology)</searchLink><br /><searchLink fieldCode="DE" term="%22Computed+tomography%22">Computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Prognosis%22">Prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+tests%22">Psychological tests</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Psychology%22">Psychology</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: <bold>Background: </bold>It has been suggested that the dimensions of cerebral ventricles are a risk factor for poor outcome in psychotic illness.<bold>Method: </bold>A cohort of 140 patients with functional psychoses of recent onset who had undergone CT scanning, were followed up for an average of 46 months and assessed on six dimensions of course and outcome of illness.<bold>Results: </bold>Left and right sylvian fissure volumes and, to a lesser extent, third ventricular volume predicted negative symptoms and unemployment over the course of follow-up, the latter association being mediated by poor cognitive functioning. There was significant linear trend in risk over the distribution of sylvian fissure volumes in the cohort, and associations were especially evident in schizophrenic patients. No associations were found with global severity of illness, duration of hospital stay, homelessness, or affective symptoms.<bold>Conclusions: </bold>These findings support the notion that dimensions of the cerebral ventricles are a continuous risk factor for some measures of outcome in the functional psychoses. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1192/bjp.166.6.750
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 750
    Subjects:
      – SubjectFull: Cerebrospinal fluid
        Type: general
      – SubjectFull: Psychoses
        Type: general
      – SubjectFull: Pathological psychology
        Type: general
      – SubjectFull: Mental illness
        Type: general
      – SubjectFull: Cerebral ventricles
        Type: general
      – SubjectFull: Suicide & psychology
        Type: general
      – SubjectFull: Unemployment & psychology
        Type: general
      – SubjectFull: Vocational rehabilitation
        Type: general
      – SubjectFull: Arousal (Physiology)
        Type: general
      – SubjectFull: Computed tomography
        Type: general
      – SubjectFull: Longitudinal method
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      – SubjectFull: Prognosis
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      – SubjectFull: Psychological tests
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      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Psychology
        Type: general
    Titles:
      – TitleFull: Increased intracerebral cerebrospinal fluid spaces predict unemployment and negative symptoms in psychotic illness. A prospective study.
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              Text: Jun95
              Type: published
              Y: 1995
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