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Ecstasy--long-term effects on the human central nervous system revealed by positron emission tomography.

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Title: Ecstasy--long-term effects on the human central nervous system revealed by positron emission tomography.
Authors: Obrocki, J., Buchert, R., Väterlein, O., Thomasius, R., Beyer, W., Schiemann, T., Väterlein, O (AUTHOR)
Source: British Journal of Psychiatry. Aug99, Vol. 175, p186-188. 3p. 1 Chart, 1 Graph.
Subjects: Ecstasy (Drug), Hallucinogenic drugs, Methamphetamine, Drug abuse, Central nervous system, Neurotoxic agents, Serotoninergic mechanisms, Glucose metabolism, Central nervous system diseases, Deoxy sugars, Radiopharmaceuticals, Positron emission tomography, Case-control method
Abstract: Background: The main psychotropic agent of the popular illicit drug ecstasy is 3,4-methylenedioxymethamphetamine (MDMA). In the light of animal studies and examinations of human cerebrospinal fluid, MDMA is suspected of causing neurotoxic lesions to the serotonergic system.Aims: To postulate a relationship between ecstasy use and lasting alterations to the cerebral glucose metabolic rate.Method: Positron emission tomography (PET) with 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) was performed on seven ecstasy users and seven subjects without any known history of illicit drug use. Data were compared for a limited number of brain regions.Results: By comparison with the control group, the glucose metabolic uptake of the ecstasy user group was altered within the amygdala, hippocampus and Brodmann's area II.Conclusions: The results suggest the possibility that ecstasy use has lasting effects on central neuronal activity in humans. [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
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DbLabel: Psychology and Behavioral Sciences Collection
An: 25202967
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
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  Data: Ecstasy--long-term effects on the human central nervous system revealed by positron emission tomography.
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  Data: <searchLink fieldCode="AR" term="%22Obrocki%2C+J%2E%22">Obrocki, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Buchert%2C+R%2E%22">Buchert, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Väterlein%2C+O%2E%22">Väterlein, O.</searchLink><br /><searchLink fieldCode="AR" term="%22Thomasius%2C+R%2E%22">Thomasius, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Beyer%2C+W%2E%22">Beyer, W.</searchLink><br /><searchLink fieldCode="AR" term="%22Schiemann%2C+T%2E%22">Schiemann, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Väterlein%2C+O%22">Väterlein, O</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22British+Journal+of+Psychiatry%22">British Journal of Psychiatry</searchLink>. Aug99, Vol. 175, p186-188. 3p. 1 Chart, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Ecstasy+%28Drug%29%22">Ecstasy (Drug)</searchLink><br /><searchLink fieldCode="DE" term="%22Hallucinogenic+drugs%22">Hallucinogenic drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Methamphetamine%22">Methamphetamine</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+abuse%22">Drug abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Central+nervous+system%22">Central nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Neurotoxic+agents%22">Neurotoxic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Serotoninergic+mechanisms%22">Serotoninergic mechanisms</searchLink><br /><searchLink fieldCode="DE" term="%22Glucose+metabolism%22">Glucose metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Central+nervous+system+diseases%22">Central nervous system diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Deoxy+sugars%22">Deoxy sugars</searchLink><br /><searchLink fieldCode="DE" term="%22Radiopharmaceuticals%22">Radiopharmaceuticals</searchLink><br /><searchLink fieldCode="DE" term="%22Positron+emission+tomography%22">Positron emission tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Case-control+method%22">Case-control method</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Background: </bold>The main psychotropic agent of the popular illicit drug ecstasy is 3,4-methylenedioxymethamphetamine (MDMA). In the light of animal studies and examinations of human cerebrospinal fluid, MDMA is suspected of causing neurotoxic lesions to the serotonergic system.<bold>Aims: </bold>To postulate a relationship between ecstasy use and lasting alterations to the cerebral glucose metabolic rate.<bold>Method: </bold>Positron emission tomography (PET) with 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) was performed on seven ecstasy users and seven subjects without any known history of illicit drug use. Data were compared for a limited number of brain regions.<bold>Results: </bold>By comparison with the control group, the glucose metabolic uptake of the ecstasy user group was altered within the amygdala, hippocampus and Brodmann's area II.<bold>Conclusions: </bold>The results suggest the possibility that ecstasy use has lasting effects on central neuronal activity in humans. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=25202967
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1192/bjp.175.2.186
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 3
        StartPage: 186
    Subjects:
      – SubjectFull: Ecstasy (Drug)
        Type: general
      – SubjectFull: Hallucinogenic drugs
        Type: general
      – SubjectFull: Methamphetamine
        Type: general
      – SubjectFull: Drug abuse
        Type: general
      – SubjectFull: Central nervous system
        Type: general
      – SubjectFull: Neurotoxic agents
        Type: general
      – SubjectFull: Serotoninergic mechanisms
        Type: general
      – SubjectFull: Glucose metabolism
        Type: general
      – SubjectFull: Central nervous system diseases
        Type: general
      – SubjectFull: Deoxy sugars
        Type: general
      – SubjectFull: Radiopharmaceuticals
        Type: general
      – SubjectFull: Positron emission tomography
        Type: general
      – SubjectFull: Case-control method
        Type: general
    Titles:
      – TitleFull: Ecstasy--long-term effects on the human central nervous system revealed by positron emission tomography.
        Type: main
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            NameFull: Obrocki, J.
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            NameFull: Buchert, R.
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            NameFull: Väterlein, O.
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            NameFull: Thomasius, R.
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            NameFull: Beyer, W.
      – PersonEntity:
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            NameFull: Schiemann, T.
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            NameFull: Väterlein, O
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          Dates:
            – D: 01
              M: 08
              Text: Aug99
              Type: published
              Y: 1999
          Identifiers:
            – Type: issn-print
              Value: 00071250
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              Value: 175
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            – TitleFull: British Journal of Psychiatry
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