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Ecstasy--long-term effects on the human central nervous system revealed by positron emission tomography.

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Bibliographic Details
Title:	Ecstasy--long-term effects on the human central nervous system revealed by positron emission tomography.
Authors:	Obrocki, J., Buchert, R., Väterlein, O., Thomasius, R., Beyer, W., Schiemann, T., Väterlein, O (AUTHOR)
Source:	British Journal of Psychiatry. Aug99, Vol. 175, p186-188. 3p. 1 Chart, 1 Graph.
Subjects:	Ecstasy (Drug), Hallucinogenic drugs, Methamphetamine, Drug abuse, Central nervous system, Neurotoxic agents, Serotoninergic mechanisms, Glucose metabolism, Central nervous system diseases, Deoxy sugars, Radiopharmaceuticals, Positron emission tomography, Case-control method
Abstract:	Background: The main psychotropic agent of the popular illicit drug ecstasy is 3,4-methylenedioxymethamphetamine (MDMA). In the light of animal studies and examinations of human cerebrospinal fluid, MDMA is suspected of causing neurotoxic lesions to the serotonergic system.Aims: To postulate a relationship between ecstasy use and lasting alterations to the cerebral glucose metabolic rate.Method: Positron emission tomography (PET) with 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) was performed on seven ecstasy users and seven subjects without any known history of illicit drug use. Data were compared for a limited number of brain regions.Results: By comparison with the control group, the glucose metabolic uptake of the ecstasy user group was altered within the amygdala, hippocampus and Brodmann's area II.Conclusions: The results suggest the possibility that ecstasy use has lasting effects on central neuronal activity in humans. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

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