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The JAZ family of repressors is the missing link in jasmonate signalling.

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Title: The JAZ family of repressors is the missing link in jasmonate signalling.
Authors: Chini, A., Fonseca, S., Fernández, G., Adie, B., Chico, J. M., Lorenzo, O., García-Casado, G., L&;#x00F3;pez-Vidriero, I., Lozano, F. M., Ponce, M. R., Micol, J. L., Solano, R.
Source: Nature. 8/9/2007, Vol. 448 Issue 7154, p666-671. 6p. 1 Color Photograph, 3 Diagrams, 1 Graph.
Subjects: Plant development, Plant growth, Plant hormones, Genetic regulation in plants, Genetic research, Plant genetics, Plant regulators, Growth regulators, Genetic repressors, Arabidopsis thaliana
Abstract: Jasmonates are essential phytohormones for plant development and survival. However, the molecular details of their signalling pathway remain largely unknown. The identification more than a decade ago of COI1 as an F-box protein suggested the existence of a repressor of jasmonate responses that is targeted by the SCFCOI1 complex for proteasome degradation in response to jasmonate. Here we report the identification of JASMONATE-INSENSITIVE 3 (JAI3) and a family of related proteins named JAZ (jasmonate ZIM-domain), in Arabidopsis thaliana. Our results demonstrate that JAI3 and other JAZs are direct targets of the SCFCOI1 E3 ubiquitin ligase and jasmonate treatment induces their proteasome degradation. Moreover, JAI3 negatively regulates the key transcriptional activator of jasmonate responses, MYC2. The JAZ family therefore represents the molecular link between the two previously known steps in the jasmonate pathway. Furthermore, we demonstrate the existence of a regulatory feed-back loop involving MYC2 and JAZ proteins, which provides a mechanistic explanation for the pulsed response to jasmonate and the subsequent desensitization of the cell. [ABSTRACT FROM AUTHOR]
Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The JAZ family of repressors is the missing link in jasmonate signalling.
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  Data: <searchLink fieldCode="AR" term="%22Chini%2C+A%2E%22">Chini, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Fonseca%2C+S%2E%22">Fonseca, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Fernández%2C+G%2E%22">Fernández, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Adie%2C+B%2E%22">Adie, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Chico%2C+J%2E+M%2E%22">Chico, J. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Lorenzo%2C+O%2E%22">Lorenzo, O.</searchLink><br /><searchLink fieldCode="AR" term="%22García-Casado%2C+G%2E%22">García-Casado, G.</searchLink><br /><searchLink fieldCode="AR" term="%22L%26%3B#x00F3%3Bpez-Vidriero%2C+I%2E%22">L&;#x00F3;pez-Vidriero, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Lozano%2C+F%2E+M%2E%22">Lozano, F. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Ponce%2C+M%2E+R%2E%22">Ponce, M. R.</searchLink><br /><searchLink fieldCode="AR" term="%22Micol%2C+J%2E+L%2E%22">Micol, J. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Solano%2C+R%2E%22">Solano, R.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 8/9/2007, Vol. 448 Issue 7154, p666-671. 6p. 1 Color Photograph, 3 Diagrams, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Plant+development%22">Plant development</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+growth%22">Plant growth</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+hormones%22">Plant hormones</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+regulation+in+plants%22">Genetic regulation in plants</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+research%22">Genetic research</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+genetics%22">Plant genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+regulators%22">Plant regulators</searchLink><br /><searchLink fieldCode="DE" term="%22Growth+regulators%22">Growth regulators</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+repressors%22">Genetic repressors</searchLink><br /><searchLink fieldCode="DE" term="%22Arabidopsis+thaliana%22">Arabidopsis thaliana</searchLink>
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  Data: Jasmonates are essential phytohormones for plant development and survival. However, the molecular details of their signalling pathway remain largely unknown. The identification more than a decade ago of COI1 as an F-box protein suggested the existence of a repressor of jasmonate responses that is targeted by the SCFCOI1 complex for proteasome degradation in response to jasmonate. Here we report the identification of JASMONATE-INSENSITIVE 3 (JAI3) and a family of related proteins named JAZ (jasmonate ZIM-domain), in Arabidopsis thaliana. Our results demonstrate that JAI3 and other JAZs are direct targets of the SCFCOI1 E3 ubiquitin ligase and jasmonate treatment induces their proteasome degradation. Moreover, JAI3 negatively regulates the key transcriptional activator of jasmonate responses, MYC2. The JAZ family therefore represents the molecular link between the two previously known steps in the jasmonate pathway. Furthermore, we demonstrate the existence of a regulatory feed-back loop involving MYC2 and JAZ proteins, which provides a mechanistic explanation for the pulsed response to jasmonate and the subsequent desensitization of the cell. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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