Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats.
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| Title: | Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats. |
|---|---|
| Authors: | Olivier, J., Jans, L., Korte-Bouws, G., Korte, S., Deen, P., Cools, A., Ellenbroek, B., Blokland, A. |
| Source: | Psychopharmacology. Oct2008, Vol. 200 Issue 2, p243-254. 12p. 2 Charts, 3 Graphs. |
| Subjects: | Tryptophan, Memory research, Laboratory rats, Serotonin |
| Abstract: | Acute tryptophan depletion (ATD) transiently lowers central serotonin levels and can induce depressive mood states and cognitive defects. Previous studies have shown that ATD impairs object recognition in rats. As individual differences exist in central serotonin neurotransmission, the impact of ATD may vary accordingly. In this experiment, we investigated the hypothesis that male serotonin transporter knockout (SERT−/−), rats marked by a lower SERT function, are more vulnerable to the effects of ATD in an object recognition task than male wildtype (SERT+/+) and heterozygous (SERT+/−) rats. Twelve male SERT+/+, SERT+/−, and SERT−/− rats were treated with standard dose and low-dose ATD using a gelatine-based protein–carbohydrate mixture lacking tryptophan. In the control treatment, l-tryptophan was added to the mixture. Four hours after treatment, the rats were subjected to the object recognition task. In addition, the effects of ATD on plasma amino acid concentrations were measured, and concentrations of 5-HT and 5-HIAA were measured in the frontal cortex and hippocampus of these rats. Plasma TRP levels and central 5-HT and 5-HIAA levels were decreased in all genotypes after ATD, but effects were stronger in SERT−/− rats. The standard dose of ATD impaired object recognition in all genotypes. SERT−/− and SERT+/− rats were more vulnerable to low dose of ATD in the object recognition task compared to SERT+/+ rats. These results indicate a greater sensitivity to ATD in SERT−/− and SERT+/− rats, which may be related to stronger central depletion effects in these rats. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 34139324 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Olivier%2C+J%2E%22">Olivier, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Jans%2C+L%2E%22">Jans, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Korte-Bouws%2C+G%2E%22">Korte-Bouws, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Korte%2C+S%2E%22">Korte, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Deen%2C+P%2E%22">Deen, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Cools%2C+A%2E%22">Cools, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Ellenbroek%2C+B%2E%22">Ellenbroek, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Blokland%2C+A%2E%22">Blokland, A.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Oct2008, Vol. 200 Issue 2, p243-254. 12p. 2 Charts, 3 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Tryptophan%22">Tryptophan</searchLink><br /><searchLink fieldCode="DE" term="%22Memory+research%22">Memory research</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin%22">Serotonin</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Acute tryptophan depletion (ATD) transiently lowers central serotonin levels and can induce depressive mood states and cognitive defects. Previous studies have shown that ATD impairs object recognition in rats. As individual differences exist in central serotonin neurotransmission, the impact of ATD may vary accordingly. In this experiment, we investigated the hypothesis that male serotonin transporter knockout (SERT−/−), rats marked by a lower SERT function, are more vulnerable to the effects of ATD in an object recognition task than male wildtype (SERT+/+) and heterozygous (SERT+/−) rats. Twelve male SERT+/+, SERT+/−, and SERT−/− rats were treated with standard dose and low-dose ATD using a gelatine-based protein–carbohydrate mixture lacking tryptophan. In the control treatment, l-tryptophan was added to the mixture. Four hours after treatment, the rats were subjected to the object recognition task. In addition, the effects of ATD on plasma amino acid concentrations were measured, and concentrations of 5-HT and 5-HIAA were measured in the frontal cortex and hippocampus of these rats. Plasma TRP levels and central 5-HT and 5-HIAA levels were decreased in all genotypes after ATD, but effects were stronger in SERT−/− rats. The standard dose of ATD impaired object recognition in all genotypes. SERT−/− and SERT+/− rats were more vulnerable to low dose of ATD in the object recognition task compared to SERT+/+ rats. These results indicate a greater sensitivity to ATD in SERT−/− and SERT+/− rats, which may be related to stronger central depletion effects in these rats. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-008-1201-0 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 243 Subjects: – SubjectFull: Tryptophan Type: general – SubjectFull: Memory research Type: general – SubjectFull: Laboratory rats Type: general – SubjectFull: Serotonin Type: general Titles: – TitleFull: Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Olivier, J. – PersonEntity: Name: NameFull: Jans, L. – PersonEntity: Name: NameFull: Korte-Bouws, G. – PersonEntity: Name: NameFull: Korte, S. – PersonEntity: Name: NameFull: Deen, P. – PersonEntity: Name: NameFull: Cools, A. – PersonEntity: Name: NameFull: Ellenbroek, B. – PersonEntity: Name: NameFull: Blokland, A. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 200 – Type: issue Value: 2 Titles: – TitleFull: Psychopharmacology Type: main |
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