View in EDS HTML Full Text PDF Full Text

Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China.

Saved in:
Bibliographic Details
Title: Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China.
Authors: London, Stephanie J, Yuan, Jian-Min, Chung, Fung-Lung, Gao, Yu-Tang, Coetzee, Gerhard A, Ross, Ronald K, Yu, Mimi C, London, S J (AUTHOR), Yuan, J M (AUTHOR), Chung, F L (AUTHOR), Gao, Y T (AUTHOR), Coetzee, G A (AUTHOR), Ross, R K (AUTHOR), Yu, M C (AUTHOR)
Source: Lancet. 8/26/2000, Vol. 356 Issue 9231, p724-729. 6p. 4 Charts.
Subjects: Cancer risk factors, Men's health, Animal models of carcinogenesis, Lung disease diagnosis
Geographic Terms: China, Shanghai (China)
Abstract: Background: Dietary isothiocyanates inhibit lung carcinogenesis in laboratory animals but human data are limited. Glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) conjugate isothiocyanates leading to more rapid elimination. Common deletion polymorphisms of GSTM1 and GSTT1 abolish enzyme activity. We hypothesised that chemopreventive effects of isothiocyanates might be heightened when enzymes that enhance their elimination are lacking.Methods: We examined the relation between total isothiocyanate concentrations in urine, collected before diagnosis, and the subsequent risk of lung cancer among 232 incident cases of lung cancer and 710 matched controls from a cohort of 18,244 men in Shanghai, China, followed from 1986 to 1997. Homozygous deletion of the GSTM1 and GSTT1 genes were determined by PCR.Findings: Individuals with detectable isothiocyanates in the urine were at decreased risk of lung cancer (smoking-adjusted relative risk for lung cancer=0.65 [95% CI 0.43-0.97]). This protective effect of isothiocyanates was seen primarily among individuals with homozygous deletion of GSTM1 (0.36 [0.20-0.63]) and particularly with deletion of both GSTM1 and GSTT1 (0.28 [0.13-0.57]).Interpretation: Isothiocyanates appeared to reduce lung-cancer risk in this cohort of Chinese men. Reduction in risk was strongest among persons genetically deficient in enzymes that rapidly eliminate these chemopreventive compounds. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 3503848
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22London%2C+Stephanie+J%22">London, Stephanie J</searchLink><br /><searchLink fieldCode="AR" term="%22Yuan%2C+Jian-Min%22">Yuan, Jian-Min</searchLink><br /><searchLink fieldCode="AR" term="%22Chung%2C+Fung-Lung%22">Chung, Fung-Lung</searchLink><br /><searchLink fieldCode="AR" term="%22Gao%2C+Yu-Tang%22">Gao, Yu-Tang</searchLink><br /><searchLink fieldCode="AR" term="%22Coetzee%2C+Gerhard+A%22">Coetzee, Gerhard A</searchLink><br /><searchLink fieldCode="AR" term="%22Ross%2C+Ronald+K%22">Ross, Ronald K</searchLink><br /><searchLink fieldCode="AR" term="%22Yu%2C+Mimi+C%22">Yu, Mimi C</searchLink><br /><searchLink fieldCode="AR" term="%22London%2C+S+J%22">London, S J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yuan%2C+J+M%22">Yuan, J M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chung%2C+F+L%22">Chung, F L</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gao%2C+Y+T%22">Gao, Y T</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Coetzee%2C+G+A%22">Coetzee, G A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ross%2C+R+K%22">Ross, R K</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yu%2C+M+C%22">Yu, M C</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 8/26/2000, Vol. 356 Issue 9231, p724-729. 6p. 4 Charts.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Cancer+risk+factors%22">Cancer risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Men's+health%22">Men's health</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+models+of+carcinogenesis%22">Animal models of carcinogenesis</searchLink><br /><searchLink fieldCode="DE" term="%22Lung+disease+diagnosis%22">Lung disease diagnosis</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22China%22">China</searchLink><br /><searchLink fieldCode="DE" term="%22Shanghai+%28China%29%22">Shanghai (China)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Background: </bold>Dietary isothiocyanates inhibit lung carcinogenesis in laboratory animals but human data are limited. Glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) conjugate isothiocyanates leading to more rapid elimination. Common deletion polymorphisms of GSTM1 and GSTT1 abolish enzyme activity. We hypothesised that chemopreventive effects of isothiocyanates might be heightened when enzymes that enhance their elimination are lacking.<bold>Methods: </bold>We examined the relation between total isothiocyanate concentrations in urine, collected before diagnosis, and the subsequent risk of lung cancer among 232 incident cases of lung cancer and 710 matched controls from a cohort of 18,244 men in Shanghai, China, followed from 1986 to 1997. Homozygous deletion of the GSTM1 and GSTT1 genes were determined by PCR.<bold>Findings: </bold>Individuals with detectable isothiocyanates in the urine were at decreased risk of lung cancer (smoking-adjusted relative risk for lung cancer=0.65 [95% CI 0.43-0.97]). This protective effect of isothiocyanates was seen primarily among individuals with homozygous deletion of GSTM1 (0.36 [0.20-0.63]) and particularly with deletion of both GSTM1 and GSTT1 (0.28 [0.13-0.57]).<bold>Interpretation: </bold>Isothiocyanates appeared to reduce lung-cancer risk in this cohort of Chinese men. Reduction in risk was strongest among persons genetically deficient in enzymes that rapidly eliminate these chemopreventive compounds. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=3503848
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/S0140-6736(00)02631-3
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 724
    Subjects:
      – SubjectFull: Cancer risk factors
        Type: general
      – SubjectFull: Men's health
        Type: general
      – SubjectFull: Animal models of carcinogenesis
        Type: general
      – SubjectFull: Lung disease diagnosis
        Type: general
      – SubjectFull: China
        Type: general
      – SubjectFull: Shanghai (China)
        Type: general
    Titles:
      – TitleFull: Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: London, Stephanie J
      – PersonEntity:
          Name:
            NameFull: Yuan, Jian-Min
      – PersonEntity:
          Name:
            NameFull: Chung, Fung-Lung
      – PersonEntity:
          Name:
            NameFull: Gao, Yu-Tang
      – PersonEntity:
          Name:
            NameFull: Coetzee, Gerhard A
      – PersonEntity:
          Name:
            NameFull: Ross, Ronald K
      – PersonEntity:
          Name:
            NameFull: Yu, Mimi C
      – PersonEntity:
          Name:
            NameFull: London, S J
      – PersonEntity:
          Name:
            NameFull: Yuan, J M
      – PersonEntity:
          Name:
            NameFull: Chung, F L
      – PersonEntity:
          Name:
            NameFull: Gao, Y T
      – PersonEntity:
          Name:
            NameFull: Coetzee, G A
      – PersonEntity:
          Name:
            NameFull: Ross, R K
      – PersonEntity:
          Name:
            NameFull: Yu, M C
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 26
              M: 08
              Text: 8/26/2000
              Type: published
              Y: 2000
          Identifiers:
            – Type: issn-print
              Value: 01406736
          Numbering:
            – Type: volume
              Value: 356
            – Type: issue
              Value: 9231
          Titles:
            – TitleFull: Lancet
              Type: main
ResultId 1