Brain activation by short-term nicotine exposure in anesthetized wild-type and beta2-nicotinic receptors knockout mice: a BOLD fMRI study.
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| Title: | Brain activation by short-term nicotine exposure in anesthetized wild-type and beta2-nicotinic receptors knockout mice: a BOLD fMRI study. |
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| Authors: | Suarez, S., Amadon, A., Giacomini, E., Wiklund, A., Changeux, J.-P., Bihan, D., Granon, S. |
| Source: | Psychopharmacology. Mar2009, Vol. 202 Issue 4, p599-610. 12p. 1 Color Photograph, 3 Diagrams, 2 Charts, 2 Graphs. |
| Subjects: | Neurosciences, Mice physiology, Laboratory mice, Physiological effects of nicotine, Nicotinic receptors |
| Abstract: | The behavioral effects of nicotine and the role of the beta2-containing nicotinic receptors in these behaviors are well documented. However, the behaviors altered by nicotine rely on the functioning on multiple brain circuits where the high-affinity beta2-containing nicotinic receptors (β2*nAChRs) are located. We intend to see which brain circuits are activated when nicotine is given in animals naïve for nicotine and whether the β2*nAChRs are needed for its activation of the blood oxygen level dependent (BOLD) signal in all brain areas. We used functional magnetic resonance imaging (fMRI) to measure the brain activation evoked by nicotine (1 mg/kg delivered at a slow rate for 45 min) in anesthetized C57BL/6J mice and beta2 knockout (KO) mice. Acute nicotine injection results in a significant increased activation in anterior frontal, motor, and somatosensory cortices and in the ventral tegmental area and the substantia nigra. Anesthetized mice receiving no nicotine injection exhibited a major decreased activation in all cortical and subcortical structures, likely due to prolonged anesthesia. At a global level, beta2 KO mice were not rescued from the globally declining BOLD signal. However, nicotine still activated regions of a meso-cortico-limbic circuit likely via alpha7 nicotinic receptors. Acute nicotine exposure compensates for the drop in brain activation due to anesthesia through the meso-cortico-limbic network via the action of nicotine on β2*nAChRs. The developed fMRI method is suitable for comparing responses in wild-type and mutant mice. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 36420066 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-008-1338-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 599 Subjects: – SubjectFull: Neurosciences Type: general – SubjectFull: Mice physiology Type: general – SubjectFull: Laboratory mice Type: general – SubjectFull: Physiological effects of nicotine Type: general – SubjectFull: Nicotinic receptors Type: general Titles: – TitleFull: Brain activation by short-term nicotine exposure in anesthetized wild-type and beta2-nicotinic receptors knockout mice: a BOLD fMRI study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Suarez, S. – PersonEntity: Name: NameFull: Amadon, A. – PersonEntity: Name: NameFull: Giacomini, E. – PersonEntity: Name: NameFull: Wiklund, A. – PersonEntity: Name: NameFull: Changeux, J.-P. – PersonEntity: Name: NameFull: Bihan, D. – PersonEntity: Name: NameFull: Granon, S. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 202 – Type: issue Value: 4 Titles: – TitleFull: Psychopharmacology Type: main |
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