View in EDS

In Utero Smoke Exposure, Glutathione S-Transferase P1 Haplotypes, and Respiratory Illness--Related Absence Among Schoolchildren.

Saved in:
Bibliographic Details
Title: In Utero Smoke Exposure, Glutathione S-Transferase P1 Haplotypes, and Respiratory Illness--Related Absence Among Schoolchildren.
Authors: Wenten, Madé, Yu-Fen Li, Pi-Chu Lin, Gauderman, W. James, Berhane, Kiros, Avol, Edward, Gilliland, Frank D.
Source: Pediatrics. May2009, Vol. 123 Issue 5, p1344-1351. 8p.
Subjects: Children's health, Respiratory diseases, Glutathione transferase, Tobacco smoke, Health of school children, Public health
Abstract: BACKGROUND. The GSTP1 Ile105Val variant and secondhand tobacco smoke exposure have been independently associated with acute respiratory illness; however, susceptibility to in utero and secondhand tobacco smoke has yet to be examined in relation to variation across the GSTP1 locus. OBJECTIVE. The purpose of this work was to determine whether variation across the GSTP1 locus is associated with respiratory illness-related school absences and to determine whether this relationship varies by in utero and secondhand tobacco smoke exposure. METHODS. Tobacco smoke exposure status, incident respiratory-related school absence records, and DNA samples was ascertained for 1132 Hispanic and non-Hispanic white elementary school children as part of the Children's Health Study. RESULTS. Four GSTP1 single-nucleotide polymorphisms were selected that accounted for 93% of the variation across the locus. Individual single-nucleotide polymorphism analyses showed a protective effect for the minor alleles in single-nucleotide polymorphisms 1 (rs6591255), 3 (GSTP1 Ile 05Val: rs1695), and 4 (rs749174) for respiratory illness. The haplotype, which includes a minor allele for single nucleotide polymorphisms 1, 3, and 4 (h1011), was associated with a decreased risk of respiratory illness. The protective effect of GSTP1 variants was lost among individuals exposed to in utero and secondhand tobacco smoke. CONCLUSIONS. A common GSTP1 haplotype, which includes the functional Ile105Val polymorphism, was associated with respiratory-related school absences. The protection afforded by this haplotype was lost in children exposed to involuntary tobacco smoke. The paradigm of loss of genetic protection among those exposed to tobacco smoke has clinical and public health implications that warrant broader consideration in research and practice. [ABSTRACT FROM AUTHOR]
Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 39753210
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: In Utero Smoke Exposure, Glutathione S-Transferase P1 Haplotypes, and Respiratory Illness--Related Absence Among Schoolchildren.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Wenten%2C+Madé%22">Wenten, Madé</searchLink><br /><searchLink fieldCode="AR" term="%22Yu-Fen+Li%22">Yu-Fen Li</searchLink><br /><searchLink fieldCode="AR" term="%22Pi-Chu+Lin%22">Pi-Chu Lin</searchLink><br /><searchLink fieldCode="AR" term="%22Gauderman%2C+W%2E+James%22">Gauderman, W. James</searchLink><br /><searchLink fieldCode="AR" term="%22Berhane%2C+Kiros%22">Berhane, Kiros</searchLink><br /><searchLink fieldCode="AR" term="%22Avol%2C+Edward%22">Avol, Edward</searchLink><br /><searchLink fieldCode="AR" term="%22Gilliland%2C+Frank+D%2E%22">Gilliland, Frank D.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. May2009, Vol. 123 Issue 5, p1344-1351. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Children's+health%22">Children's health</searchLink><br /><searchLink fieldCode="DE" term="%22Respiratory+diseases%22">Respiratory diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Glutathione+transferase%22">Glutathione transferase</searchLink><br /><searchLink fieldCode="DE" term="%22Tobacco+smoke%22">Tobacco smoke</searchLink><br /><searchLink fieldCode="DE" term="%22Health+of+school+children%22">Health of school children</searchLink><br /><searchLink fieldCode="DE" term="%22Public+health%22">Public health</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: BACKGROUND. The GSTP1 Ile105Val variant and secondhand tobacco smoke exposure have been independently associated with acute respiratory illness; however, susceptibility to in utero and secondhand tobacco smoke has yet to be examined in relation to variation across the GSTP1 locus. OBJECTIVE. The purpose of this work was to determine whether variation across the GSTP1 locus is associated with respiratory illness-related school absences and to determine whether this relationship varies by in utero and secondhand tobacco smoke exposure. METHODS. Tobacco smoke exposure status, incident respiratory-related school absence records, and DNA samples was ascertained for 1132 Hispanic and non-Hispanic white elementary school children as part of the Children's Health Study. RESULTS. Four GSTP1 single-nucleotide polymorphisms were selected that accounted for 93% of the variation across the locus. Individual single-nucleotide polymorphism analyses showed a protective effect for the minor alleles in single-nucleotide polymorphisms 1 (rs6591255), 3 (GSTP1 Ile 05Val: rs1695), and 4 (rs749174) for respiratory illness. The haplotype, which includes a minor allele for single nucleotide polymorphisms 1, 3, and 4 (h1011), was associated with a decreased risk of respiratory illness. The protective effect of GSTP1 variants was lost among individuals exposed to in utero and secondhand tobacco smoke. CONCLUSIONS. A common GSTP1 haplotype, which includes the functional Ile105Val polymorphism, was associated with respiratory-related school absences. The protection afforded by this haplotype was lost in children exposed to involuntary tobacco smoke. The paradigm of loss of genetic protection among those exposed to tobacco smoke has clinical and public health implications that warrant broader consideration in research and practice. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=39753210
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1542/peds.2008-1892
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 1344
    Subjects:
      – SubjectFull: Children's health
        Type: general
      – SubjectFull: Respiratory diseases
        Type: general
      – SubjectFull: Glutathione transferase
        Type: general
      – SubjectFull: Tobacco smoke
        Type: general
      – SubjectFull: Health of school children
        Type: general
      – SubjectFull: Public health
        Type: general
    Titles:
      – TitleFull: In Utero Smoke Exposure, Glutathione S-Transferase P1 Haplotypes, and Respiratory Illness--Related Absence Among Schoolchildren.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Wenten, Madé
      – PersonEntity:
          Name:
            NameFull: Yu-Fen Li
      – PersonEntity:
          Name:
            NameFull: Pi-Chu Lin
      – PersonEntity:
          Name:
            NameFull: Gauderman, W. James
      – PersonEntity:
          Name:
            NameFull: Berhane, Kiros
      – PersonEntity:
          Name:
            NameFull: Avol, Edward
      – PersonEntity:
          Name:
            NameFull: Gilliland, Frank D.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2009
              Type: published
              Y: 2009
          Identifiers:
            – Type: issn-print
              Value: 00314005
          Numbering:
            – Type: volume
              Value: 123
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Pediatrics
              Type: main
ResultId 1