Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
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| Title: | Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. |
|---|---|
| Authors: | Harrison, David E., Strong, Randy, Sharp, Zelton Dave, Nelson, James F., Astle, Clinton M., Flurkey, Kevin, Nadon, Nancy L., Wilkinson, J. Erby, Frenkel, Krystyna, Carter, Christy S., Pahor, Marco, Javors, Martin A., Fernandez, Elizabeth, Miller, Richard A. |
| Source: | Nature. 7/16/2009, Vol. 460 Issue 7253, p392-395. 4p. 1 Chart, 3 Graphs. |
| Subjects: | Invertebrates, Rare invertebrates, Invertebrates as carriers of disease, Yeast, Nematodes, Fruit flies, Mediterranean fruit-fly, Drosophila |
| Abstract: | Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruitflies; however, whether inhibition of mTOR signalling can extend lifespan in a mammalian species was unknown. Here we report that rapamycin, an inhibitor of the mTOR pathway, extends median and maximal lifespan of both male and female mice when fed beginning at 600 days of age. On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males. The effect was seen at three independent test sites in genetically heterogeneous mice, chosen to avoid genotype-specific effects on disease susceptibility. Disease patterns of rapamycin-treated mice did not differ from those of control mice. In a separate study, rapamycin fed to mice beginning at 270 days of age also increased survival in both males and females, based on an interim analysis conducted near the median survival point. Rapamycin may extend lifespan by postponing death from cancer, by retarding mechanisms of ageing, or both. To our knowledge, these are the first results to demonstrate a role for mTOR signalling in the regulation of mammalian lifespan, as well as pharmacological extension of lifespan in both genders. These findings have implications for further development of interventions targeting mTOR for the treatment and prevention of age-related diseases. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 43217724 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/nature08221 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 392 Subjects: – SubjectFull: Invertebrates Type: general – SubjectFull: Rare invertebrates Type: general – SubjectFull: Invertebrates as carriers of disease Type: general – SubjectFull: Yeast Type: general – SubjectFull: Nematodes Type: general – SubjectFull: Fruit flies Type: general – SubjectFull: Mediterranean fruit-fly Type: general – SubjectFull: Drosophila Type: general Titles: – TitleFull: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Harrison, David E. – PersonEntity: Name: NameFull: Strong, Randy – PersonEntity: Name: NameFull: Sharp, Zelton Dave – PersonEntity: Name: NameFull: Nelson, James F. – PersonEntity: Name: NameFull: Astle, Clinton M. – PersonEntity: Name: NameFull: Flurkey, Kevin – PersonEntity: Name: NameFull: Nadon, Nancy L. – PersonEntity: Name: NameFull: Wilkinson, J. Erby – PersonEntity: Name: NameFull: Frenkel, Krystyna – PersonEntity: Name: NameFull: Carter, Christy S. – PersonEntity: Name: NameFull: Pahor, Marco – PersonEntity: Name: NameFull: Javors, Martin A. – PersonEntity: Name: NameFull: Fernandez, Elizabeth – PersonEntity: Name: NameFull: Miller, Richard A. IsPartOfRelationships: – BibEntity: Dates: – D: 16 M: 07 Text: 7/16/2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 00280836 Numbering: – Type: volume Value: 460 – Type: issue Value: 7253 Titles: – TitleFull: Nature Type: main |
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