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Association of the DTNBP1 genotype with cognition and personality traits in healthy subjects.

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Title: Association of the DTNBP1 genotype with cognition and personality traits in healthy subjects.
Authors: Kircher, T., Markov, V., Krug, A., Eggermann, T., Zerres, K., Nöthen, M. M., Skowronek, M. H., Rietschel, M.
Source: Psychological Medicine. Oct2009, Vol. 39 Issue 10, p1657-1665. 9p. 1 Chart.
Subjects: Schizophrenia, Experiments, Personality & cognition, Cognitive ability, Genes
Abstract: Background. Schizophrenia is a complex disorder with a high heritability. Family members have an increased risk not only for schizophrenia per se but also for schizophrenia spectrum disorders. Impairment of neuropsychological functions found in schizophrenia patients are also frequently observed in their relatives. The dystrobrevin-binding protein 1 (DTNBP1) gene located at chromosome 6p22.3 is one of the most often replicated vulnerability genes for schizophrenia. In addition, this gene has been shown to modulate general cognitive abilities both in healthy subjects and in patients with schizophrenia. Method. In a sample of 521 healthy subjects we investigated an association between the DTNBP1 genotype [single nucleotide polymorphism (SNP) rs1018381], personality traits [using the NEO Five-Factor Inventory (NEO-FFI) and the Schizotypal Personality Questionnaire - Brief Version (SPQ-B)] and cognitive function (estimated IQ, verbal fluency, attention, working memory and executive function). Results. Significantly lower scores on the SPQ-B (p=0.0005) and the Interpersonal Deficit subscale (p=0.0005) in carriers of the A-risk allele were detected. There were no differences in any of the cognitive variables between groups. Conclusions. The results indicate that genetic variation of the DTNBP1 genotype might exert gene-specific modulating effects on schizophrenia endophenotypes at the population level. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Association of the DTNBP1 genotype with cognition and personality traits in healthy subjects.
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  Data: <searchLink fieldCode="AR" term="%22Kircher%2C+T%2E%22">Kircher, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Markov%2C+V%2E%22">Markov, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Krug%2C+A%2E%22">Krug, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Eggermann%2C+T%2E%22">Eggermann, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Zerres%2C+K%2E%22">Zerres, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Nöthen%2C+M%2E+M%2E%22">Nöthen, M. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Skowronek%2C+M%2E+H%2E%22">Skowronek, M. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Rietschel%2C+M%2E%22">Rietschel, M.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Oct2009, Vol. 39 Issue 10, p1657-1665. 9p. 1 Chart.
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  Data: <searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Experiments%22">Experiments</searchLink><br /><searchLink fieldCode="DE" term="%22Personality+%26+cognition%22">Personality & cognition</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink><br /><searchLink fieldCode="DE" term="%22Genes%22">Genes</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background. Schizophrenia is a complex disorder with a high heritability. Family members have an increased risk not only for schizophrenia per se but also for schizophrenia spectrum disorders. Impairment of neuropsychological functions found in schizophrenia patients are also frequently observed in their relatives. The dystrobrevin-binding protein 1 (DTNBP1) gene located at chromosome 6p22.3 is one of the most often replicated vulnerability genes for schizophrenia. In addition, this gene has been shown to modulate general cognitive abilities both in healthy subjects and in patients with schizophrenia. Method. In a sample of 521 healthy subjects we investigated an association between the DTNBP1 genotype [single nucleotide polymorphism (SNP) rs1018381], personality traits [using the NEO Five-Factor Inventory (NEO-FFI) and the Schizotypal Personality Questionnaire - Brief Version (SPQ-B)] and cognitive function (estimated IQ, verbal fluency, attention, working memory and executive function). Results. Significantly lower scores on the SPQ-B (p=0.0005) and the Interpersonal Deficit subscale (p=0.0005) in carriers of the A-risk allele were detected. There were no differences in any of the cognitive variables between groups. Conclusions. The results indicate that genetic variation of the DTNBP1 genotype might exert gene-specific modulating effects on schizophrenia endophenotypes at the population level. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Oct2009
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