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Slow wave sleep and dopaminergic treatment in Parkinson’s disease: a polysomnographic study.

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Title: Slow wave sleep and dopaminergic treatment in Parkinson’s disease: a polysomnographic study.
Authors: Diederich, N. J., Paolini, V., Vaillant, M.
Source: Acta Neurologica Scandinavica. Nov2009, Vol. 120 Issue 5, p308-313. 6p. 3 Charts, 1 Graph.
Subjects: Parkinson's disease, Rapid eye movement sleep, Regression analysis, Multivariate analysis, Extrapyramidal disorders
Abstract: Background – In Parkinson’s disease (PD), there is entanglement of disease-inherent and treatment-induced sleep abnormalities. So far, there has been no study specifically investigating the influence of diurnal dopaminergic medication (DM) on nocturnal slow wave sleep (SWS). Methods – Polysomnographic analysis in 62 PD patients. Results – PD patients had a sleep efficiency of 70 ± 17% and an SWS amount of 16 ± 11%. Linear regression analysis showed no significant correlation between the amounts of SWS and DM. However, patients with a medium DM dosage (300–600 mg of levodopa equivalents) preserved a SWS percentage >25% ( p = 0.035, χ2 test) more frequently than patients with higher or smaller DM. The DM dosage had no effect on other main sleep parameters. Psychotropic comedication had no effect on SWS percentage. In contrast, SWS amount was inversely correlated with both disease duration and age. It was independent of rapid eye movement sleep amount. The natural female bonus effect on SWS amount was absent in women with PD. Conclusion – Diurnal dopaminergic treatment has no major impact on SWS in PD, which, however, decreases with disease duration. Disease-dependent, but treatment-independent decrease in SWS suggests primary degeneration of sleep-regulating systems in PD. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Slow wave sleep and dopaminergic treatment in Parkinson’s disease: a polysomnographic study.
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  Data: <searchLink fieldCode="AR" term="%22Diederich%2C+N%2E+J%2E%22">Diederich, N. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Paolini%2C+V%2E%22">Paolini, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Vaillant%2C+M%2E%22">Vaillant, M.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Nov2009, Vol. 120 Issue 5, p308-313. 6p. 3 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Rapid+eye+movement+sleep%22">Rapid eye movement sleep</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Multivariate+analysis%22">Multivariate analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Extrapyramidal+disorders%22">Extrapyramidal disorders</searchLink>
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  Label: Abstract
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  Data: Background – In Parkinson’s disease (PD), there is entanglement of disease-inherent and treatment-induced sleep abnormalities. So far, there has been no study specifically investigating the influence of diurnal dopaminergic medication (DM) on nocturnal slow wave sleep (SWS). Methods – Polysomnographic analysis in 62 PD patients. Results – PD patients had a sleep efficiency of 70 ± 17% and an SWS amount of 16 ± 11%. Linear regression analysis showed no significant correlation between the amounts of SWS and DM. However, patients with a medium DM dosage (300–600 mg of levodopa equivalents) preserved a SWS percentage >25% ( p = 0.035, χ2 test) more frequently than patients with higher or smaller DM. The DM dosage had no effect on other main sleep parameters. Psychotropic comedication had no effect on SWS percentage. In contrast, SWS amount was inversely correlated with both disease duration and age. It was independent of rapid eye movement sleep amount. The natural female bonus effect on SWS amount was absent in women with PD. Conclusion – Diurnal dopaminergic treatment has no major impact on SWS in PD, which, however, decreases with disease duration. Disease-dependent, but treatment-independent decrease in SWS suggests primary degeneration of sleep-regulating systems in PD. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Nov2009
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