Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial.
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| Title: | Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial. |
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| Authors: | Pratley, Richard E., Nauck, Michael, Bailey, Timothy, Montanya, Eduard, Cuddihy, Robert, Filetti, Sebastiano, Thomsen, Anne Bloch, Sønderqaard, Rie Elvang, Davies, Melanie |
| Source: | Lancet. 4/24/2010, Vol. 375 Issue 9724, p1447-1456. 10p. 1 Diagram, 3 Charts, 3 Graphs. |
| Subjects: | Type 2 diabetes treatment, Drug efficacy, Glucagon-like peptide 1, Clinical drug trials, Hypoglycemic agents, Metformin |
| Abstract: | The article details a study which investigated the efficacy and safety of human glucagon-like peptide-1 (GLP-1) analogue liraglutide compared to dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin. The study included patients with type 2 diabetes mellitus who have inadequate glycemic control on metformin. It found that liraglutide is more efficient than sitagliptin in terms of lowering HbA1a>. Study authors also found that liraglutide was well tolerated than sitagliptin, and has lower risk for hypoglycemia. They concluded that liraglutide is an effective GLP-1 agent in combination with metformin. |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 49753719 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Pratley%2C+Richard+E%2E%22">Pratley, Richard E.</searchLink><br /><searchLink fieldCode="AR" term="%22Nauck%2C+Michael%22">Nauck, Michael</searchLink><br /><searchLink fieldCode="AR" term="%22Bailey%2C+Timothy%22">Bailey, Timothy</searchLink><br /><searchLink fieldCode="AR" term="%22Montanya%2C+Eduard%22">Montanya, Eduard</searchLink><br /><searchLink fieldCode="AR" term="%22Cuddihy%2C+Robert%22">Cuddihy, Robert</searchLink><br /><searchLink fieldCode="AR" term="%22Filetti%2C+Sebastiano%22">Filetti, Sebastiano</searchLink><br /><searchLink fieldCode="AR" term="%22Thomsen%2C+Anne+Bloch%22">Thomsen, Anne Bloch</searchLink><br /><searchLink fieldCode="AR" term="%22Sønderqaard%2C+Rie+Elvang%22">Sønderqaard, Rie Elvang</searchLink><br /><searchLink fieldCode="AR" term="%22Davies%2C+Melanie%22">Davies, Melanie</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 4/24/2010, Vol. 375 Issue 9724, p1447-1456. 10p. 1 Diagram, 3 Charts, 3 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Type+2+diabetes+treatment%22">Type 2 diabetes treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+efficacy%22">Drug efficacy</searchLink><br /><searchLink fieldCode="DE" term="%22Glucagon-like+peptide+1%22">Glucagon-like peptide 1</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+drug+trials%22">Clinical drug trials</searchLink><br /><searchLink fieldCode="DE" term="%22Hypoglycemic+agents%22">Hypoglycemic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Metformin%22">Metformin</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The article details a study which investigated the efficacy and safety of human glucagon-like peptide-1 (GLP-1) analogue liraglutide compared to dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin. The study included patients with type 2 diabetes mellitus who have inadequate glycemic control on metformin. It found that liraglutide is more efficient than sitagliptin in terms of lowering HbA1a>. Study authors also found that liraglutide was well tolerated than sitagliptin, and has lower risk for hypoglycemia. They concluded that liraglutide is an effective GLP-1 agent in combination with metformin. |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=49753719 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S0140-6736(10)60307-8 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 1447 Subjects: – SubjectFull: Type 2 diabetes treatment Type: general – SubjectFull: Drug efficacy Type: general – SubjectFull: Glucagon-like peptide 1 Type: general – SubjectFull: Clinical drug trials Type: general – SubjectFull: Hypoglycemic agents Type: general – SubjectFull: Metformin Type: general Titles: – TitleFull: Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Pratley, Richard E. – PersonEntity: Name: NameFull: Nauck, Michael – PersonEntity: Name: NameFull: Bailey, Timothy – PersonEntity: Name: NameFull: Montanya, Eduard – PersonEntity: Name: NameFull: Cuddihy, Robert – PersonEntity: Name: NameFull: Filetti, Sebastiano – PersonEntity: Name: NameFull: Thomsen, Anne Bloch – PersonEntity: Name: NameFull: Sønderqaard, Rie Elvang – PersonEntity: Name: NameFull: Davies, Melanie IsPartOfRelationships: – BibEntity: Dates: – D: 24 M: 04 Text: 4/24/2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 01406736 Numbering: – Type: volume Value: 375 – Type: issue Value: 9724 Titles: – TitleFull: Lancet Type: main |
| ResultId | 1 |
