ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity.
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| Title: | ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity. |
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| Authors: | Jiaping Gu, Chi Wai Lee, Yanjie Fan, Komlos, Daniel, Xin Tang, Chicheng Sun, Kuai Yu, Hartzell, H. Criss, Gong Chen, Bamburg, James R., Zheng, James Q. |
| Source: | Nature Neuroscience. Oct2010, Vol. 13 Issue 10, p1208-1215. 8p. 3 Color Photographs, 1 Diagram, 4 Graphs. |
| Subjects: | Dendritic cells, Actin, Neuroplasticity, Proteins, Phosphorylation |
| Abstract: | Dendritic spines undergo actin-based growth and shrinkage during synaptic plasticity, in which the actin depolymerizing factor (ADF)/cofilin family of actin-associated proteins are important. Elevated ADF/cofilin activities often lead to reduced spine size and immature spine morphology but can also enhance synaptic potentiation in some cases. Thus, ADF/cofilin may have distinct effects on postsynaptic structure and function. We found that ADF/cofilin-mediated actin dynamics regulated AMPA receptor (AMPAR) trafficking during synaptic potentiation, which was distinct from actin's structural role in spine morphology. Specifically, elevated ADF/cofilin activity markedly enhanced surface addition of AMPARs after chemically induced long-term potentiation (LTP), whereas inhibition of ADF/cofilin abolished AMPAR addition. We found that chemically induced LTP elicited a temporal sequence of ADF/cofilin dephosphorylation and phosphorylation that underlies AMPAR trafficking and spine enlargement. These findings suggest that temporally regulated ADF/cofilin activities function in postsynaptic modifications of receptor number and spine size during synaptic plasticity. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 53960981 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Jiaping+Gu%22">Jiaping Gu</searchLink><br /><searchLink fieldCode="AR" term="%22Chi+Wai+Lee%22">Chi Wai Lee</searchLink><br /><searchLink fieldCode="AR" term="%22Yanjie+Fan%22">Yanjie Fan</searchLink><br /><searchLink fieldCode="AR" term="%22Komlos%2C+Daniel%22">Komlos, Daniel</searchLink><br /><searchLink fieldCode="AR" term="%22Xin+Tang%22">Xin Tang</searchLink><br /><searchLink fieldCode="AR" term="%22Chicheng+Sun%22">Chicheng Sun</searchLink><br /><searchLink fieldCode="AR" term="%22Kuai+Yu%22">Kuai Yu</searchLink><br /><searchLink fieldCode="AR" term="%22Hartzell%2C+H%2E+Criss%22">Hartzell, H. Criss</searchLink><br /><searchLink fieldCode="AR" term="%22Gong+Chen%22">Gong Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Bamburg%2C+James+R%2E%22">Bamburg, James R.</searchLink><br /><searchLink fieldCode="AR" term="%22Zheng%2C+James+Q%2E%22">Zheng, James Q.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Oct2010, Vol. 13 Issue 10, p1208-1215. 8p. 3 Color Photographs, 1 Diagram, 4 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Dendritic+cells%22">Dendritic cells</searchLink><br /><searchLink fieldCode="DE" term="%22Actin%22">Actin</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroplasticity%22">Neuroplasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Proteins%22">Proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Phosphorylation%22">Phosphorylation</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Dendritic spines undergo actin-based growth and shrinkage during synaptic plasticity, in which the actin depolymerizing factor (ADF)/cofilin family of actin-associated proteins are important. Elevated ADF/cofilin activities often lead to reduced spine size and immature spine morphology but can also enhance synaptic potentiation in some cases. Thus, ADF/cofilin may have distinct effects on postsynaptic structure and function. We found that ADF/cofilin-mediated actin dynamics regulated AMPA receptor (AMPAR) trafficking during synaptic potentiation, which was distinct from actin's structural role in spine morphology. Specifically, elevated ADF/cofilin activity markedly enhanced surface addition of AMPARs after chemically induced long-term potentiation (LTP), whereas inhibition of ADF/cofilin abolished AMPAR addition. We found that chemically induced LTP elicited a temporal sequence of ADF/cofilin dephosphorylation and phosphorylation that underlies AMPAR trafficking and spine enlargement. These findings suggest that temporally regulated ADF/cofilin activities function in postsynaptic modifications of receptor number and spine size during synaptic plasticity. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/nn.2634 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 1208 Subjects: – SubjectFull: Dendritic cells Type: general – SubjectFull: Actin Type: general – SubjectFull: Neuroplasticity Type: general – SubjectFull: Proteins Type: general – SubjectFull: Phosphorylation Type: general Titles: – TitleFull: ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jiaping Gu – PersonEntity: Name: NameFull: Chi Wai Lee – PersonEntity: Name: NameFull: Yanjie Fan – PersonEntity: Name: NameFull: Komlos, Daniel – PersonEntity: Name: NameFull: Xin Tang – PersonEntity: Name: NameFull: Chicheng Sun – PersonEntity: Name: NameFull: Kuai Yu – PersonEntity: Name: NameFull: Hartzell, H. Criss – PersonEntity: Name: NameFull: Gong Chen – PersonEntity: Name: NameFull: Bamburg, James R. – PersonEntity: Name: NameFull: Zheng, James Q. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 10976256 Numbering: – Type: volume Value: 13 – Type: issue Value: 10 Titles: – TitleFull: Nature Neuroscience Type: main |
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