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Management and pitfalls of stage I/II glottic cancer.

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Title: Management and pitfalls of stage I/II glottic cancer.
Authors: Tateya, Ichiro, Hirano, Shigeru, Kitamura, Morimasa, Kada, Shinpei, Ishikawa, Seiji, Kanda, Tomoko, Asato, Ryo, Tanaka, Shinzo, Ito, Juichi
Source: Acta Oto-Laryngologica (Supplement). Nov2010 Supplement 563, Vol. 130, p62-67. 6p. 6 Charts, 2 Graphs.
Subjects: Voice disorders, Pharynx surgery, Academic medical centers, Analysis of variance, Cancer relapse, Glottis, Laryngectomy, Laryngoscopy, Health outcome assessment, Survival analysis (Biometry), Pharyngeal cancer, Survival, Tumor classification, Treatment effectiveness, Radiotherapy, Prevention, Prognosis, Diagnosis
Geographic Terms: Japan
Abstract: Conclusions: Once-daily radiotherapy for stage I glottic cancer and hyperfractionated radiotherapy for stage II glottic cancer achieved satisfactory results in terms of prognosis and laryngeal preservation. The treatment strategy for stage II glottal cancer with subglottal invasion needs to be reconsidered to further improve the outcome. Objectives: Although early glottic carcinomas are highly curable by radiation therapy, the laryngeal preservation rate is not always sufficient. We reviewed the stage I/II glottal cancer treated in our institute during a recent 15-year period to improve the outcome and prognosis. Methods: In all, 113 cases of stage I/II glottic cancer (81 stage I cases and 32 stage II cases) were treated in Kyoto University hospital from 1994 to 2008. In 81 cases with stage I glottic cancer, radiation was performed for 66 cases, transoral laser excision (TLE) was performed for 14 cases, and hyperfractionated radiotherapy was done for one case. Among 32 cases with stage II glottic cancer, 24 cases were treated with hyperfractionated radiotherapy, 6 cases were treated with radiation, and one case with partial laryngectomy. Total laryngectomy was performed for one patient who suffered mixed connective tissue disease. Kaplan-Meier estimates were used for the analysis of survival rate and laryngeal preservation rate. Results: The 5-year overall survival rates were 88.4% in stage I cases and 89.1% in stage II cases. The 5-year disease-specific survival rates were 100% in stage I cases and 93% in stage II cases. The 5-year laryngeal preservation rates were 99% in stage I cases and 90% in stage II cases. Two cases of stage II glottal cancer with subglottal invasion failed to be controlled and the patients died from local recurrence and mediastinum lymph node metastasis, respectively. [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica (Supplement) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Management and pitfalls of stage I/II glottic cancer.
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  Data: <searchLink fieldCode="AR" term="%22Tateya%2C+Ichiro%22">Tateya, Ichiro</searchLink><br /><searchLink fieldCode="AR" term="%22Hirano%2C+Shigeru%22">Hirano, Shigeru</searchLink><br /><searchLink fieldCode="AR" term="%22Kitamura%2C+Morimasa%22">Kitamura, Morimasa</searchLink><br /><searchLink fieldCode="AR" term="%22Kada%2C+Shinpei%22">Kada, Shinpei</searchLink><br /><searchLink fieldCode="AR" term="%22Ishikawa%2C+Seiji%22">Ishikawa, Seiji</searchLink><br /><searchLink fieldCode="AR" term="%22Kanda%2C+Tomoko%22">Kanda, Tomoko</searchLink><br /><searchLink fieldCode="AR" term="%22Asato%2C+Ryo%22">Asato, Ryo</searchLink><br /><searchLink fieldCode="AR" term="%22Tanaka%2C+Shinzo%22">Tanaka, Shinzo</searchLink><br /><searchLink fieldCode="AR" term="%22Ito%2C+Juichi%22">Ito, Juichi</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica+%28Supplement%29%22">Acta Oto-Laryngologica (Supplement)</searchLink>. Nov2010 Supplement 563, Vol. 130, p62-67. 6p. 6 Charts, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Voice+disorders%22">Voice disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Pharynx+surgery%22">Pharynx surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Academic+medical+centers%22">Academic medical centers</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+relapse%22">Cancer relapse</searchLink><br /><searchLink fieldCode="DE" term="%22Glottis%22">Glottis</searchLink><br /><searchLink fieldCode="DE" term="%22Laryngectomy%22">Laryngectomy</searchLink><br /><searchLink fieldCode="DE" term="%22Laryngoscopy%22">Laryngoscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Health+outcome+assessment%22">Health outcome assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Survival+analysis+%28Biometry%29%22">Survival analysis (Biometry)</searchLink><br /><searchLink fieldCode="DE" term="%22Pharyngeal+cancer%22">Pharyngeal cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Survival%22">Survival</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+classification%22">Tumor classification</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Radiotherapy%22">Radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Prevention%22">Prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Prognosis%22">Prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Japan%22">Japan</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Conclusions: Once-daily radiotherapy for stage I glottic cancer and hyperfractionated radiotherapy for stage II glottic cancer achieved satisfactory results in terms of prognosis and laryngeal preservation. The treatment strategy for stage II glottal cancer with subglottal invasion needs to be reconsidered to further improve the outcome. Objectives: Although early glottic carcinomas are highly curable by radiation therapy, the laryngeal preservation rate is not always sufficient. We reviewed the stage I/II glottal cancer treated in our institute during a recent 15-year period to improve the outcome and prognosis. Methods: In all, 113 cases of stage I/II glottic cancer (81 stage I cases and 32 stage II cases) were treated in Kyoto University hospital from 1994 to 2008. In 81 cases with stage I glottic cancer, radiation was performed for 66 cases, transoral laser excision (TLE) was performed for 14 cases, and hyperfractionated radiotherapy was done for one case. Among 32 cases with stage II glottic cancer, 24 cases were treated with hyperfractionated radiotherapy, 6 cases were treated with radiation, and one case with partial laryngectomy. Total laryngectomy was performed for one patient who suffered mixed connective tissue disease. Kaplan-Meier estimates were used for the analysis of survival rate and laryngeal preservation rate. Results: The 5-year overall survival rates were 88.4% in stage I cases and 89.1% in stage II cases. The 5-year disease-specific survival rates were 100% in stage I cases and 93% in stage II cases. The 5-year laryngeal preservation rates were 99% in stage I cases and 90% in stage II cases. Two cases of stage II glottal cancer with subglottal invasion failed to be controlled and the patients died from local recurrence and mediastinum lymph node metastasis, respectively. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Acta Oto-Laryngologica (Supplement) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.3109/00016489.2010.489574
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      – Code: eng
        Text: English
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        PageCount: 6
        StartPage: 62
    Subjects:
      – SubjectFull: Voice disorders
        Type: general
      – SubjectFull: Pharynx surgery
        Type: general
      – SubjectFull: Academic medical centers
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Cancer relapse
        Type: general
      – SubjectFull: Glottis
        Type: general
      – SubjectFull: Laryngectomy
        Type: general
      – SubjectFull: Laryngoscopy
        Type: general
      – SubjectFull: Health outcome assessment
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      – SubjectFull: Survival analysis (Biometry)
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      – SubjectFull: Pharyngeal cancer
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      – SubjectFull: Survival
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      – SubjectFull: Tumor classification
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      – SubjectFull: Treatment effectiveness
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      – SubjectFull: Radiotherapy
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      – SubjectFull: Prognosis
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      – SubjectFull: Diagnosis
        Type: general
      – SubjectFull: Japan
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      – TitleFull: Management and pitfalls of stage I/II glottic cancer.
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              Text: Nov2010 Supplement 563
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