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Exogenous ghrelin accentuates the acute hypoxic ventilatory response after two weeks of chronic hypoxia in conscious rats.

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Title: Exogenous ghrelin accentuates the acute hypoxic ventilatory response after two weeks of chronic hypoxia in conscious rats.
Authors: Schwenke, D. O., Pearson, J. T., Kangawa, K., Cragg, P. A., Shirai, M.
Source: Acta Physiologica. Nov2010, Vol. 200 Issue 3, p279-287. 9p. 1 Diagram, 2 Charts, 3 Graphs.
Subjects: Ghrelin, Pulmonary artery abnormalities, Hypoxemia, Gastrointestinal hormones, Laboratory rats, Pulmonary hypertension treatment, Therapeutics
Abstract: Aim: Ghrelin has been implicated as a modulator of numerous physiological pathways. To date, there have not been any studies describing the role of ghrelin in modulating the chemoreflex control of pulmonary ventilation. Yet the respiratory system impacts, at least to some degree, on virtually all homeostatic control systems. Chronic hypoxia (CH) can cause fundamental changes in ventilatory control, evident by alterations in the acute hypoxia ventilatory response (HVR). As ghrelin plays an important role in metabolic homeostasis, which is tightly linked to ventilatory control, we hypothesized that ghrelin may modulate HVR, especially following CH. Methods: Whole body plethysmography was used to measure the HVR (8% O2 for 10 min) in male Sprague-Dawley rats (body wt ∼180-220 g) before and after 14 days of CH (CH = 10% O2). During CH, rats received daily subcutaneous injections of either saline (control; n = 5) or ghrelin (150 μg kg−1 day−1; n = 5). The HVR was measured in another four rats that had received daily injections of ghrelin during normoxia for 7 days. Results: Ghrelin did not significantly alter basal ventilatory drive or acute HVR in normoxic rats. However, the acute HVR was accentuated following CH in ghrelin-treated rats compared with saline-treated rats. Conclusions: These results describe the impact that ghrelin has in altering ventilatory control following CH and, although the mechanisms remain to be fully elucidated, provide guidance for future ghrelin-based studies interpreting physiological data indirectly related to the chemoreflex control of pulmonary ventilation. [ABSTRACT FROM AUTHOR]
Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Exogenous ghrelin accentuates the acute hypoxic ventilatory response after two weeks of chronic hypoxia in conscious rats.
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  Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica%22">Acta Physiologica</searchLink>. Nov2010, Vol. 200 Issue 3, p279-287. 9p. 1 Diagram, 2 Charts, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Ghrelin%22">Ghrelin</searchLink><br /><searchLink fieldCode="DE" term="%22Pulmonary+artery+abnormalities%22">Pulmonary artery abnormalities</searchLink><br /><searchLink fieldCode="DE" term="%22Hypoxemia%22">Hypoxemia</searchLink><br /><searchLink fieldCode="DE" term="%22Gastrointestinal+hormones%22">Gastrointestinal hormones</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink><br /><searchLink fieldCode="DE" term="%22Pulmonary+hypertension+treatment%22">Pulmonary hypertension treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink>
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  Data: Aim: Ghrelin has been implicated as a modulator of numerous physiological pathways. To date, there have not been any studies describing the role of ghrelin in modulating the chemoreflex control of pulmonary ventilation. Yet the respiratory system impacts, at least to some degree, on virtually all homeostatic control systems. Chronic hypoxia (CH) can cause fundamental changes in ventilatory control, evident by alterations in the acute hypoxia ventilatory response (HVR). As ghrelin plays an important role in metabolic homeostasis, which is tightly linked to ventilatory control, we hypothesized that ghrelin may modulate HVR, especially following CH. Methods: Whole body plethysmography was used to measure the HVR (8% O2 for 10 min) in male Sprague-Dawley rats (body wt ∼180-220 g) before and after 14 days of CH (CH = 10% O2). During CH, rats received daily subcutaneous injections of either saline (control; n = 5) or ghrelin (150 μg kg−1 day−1; n = 5). The HVR was measured in another four rats that had received daily injections of ghrelin during normoxia for 7 days. Results: Ghrelin did not significantly alter basal ventilatory drive or acute HVR in normoxic rats. However, the acute HVR was accentuated following CH in ghrelin-treated rats compared with saline-treated rats. Conclusions: These results describe the impact that ghrelin has in altering ventilatory control following CH and, although the mechanisms remain to be fully elucidated, provide guidance for future ghrelin-based studies interpreting physiological data indirectly related to the chemoreflex control of pulmonary ventilation. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/j.1748-1716.2010.02142.x
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      – SubjectFull: Pulmonary artery abnormalities
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      – SubjectFull: Hypoxemia
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      – SubjectFull: Therapeutics
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      – TitleFull: Exogenous ghrelin accentuates the acute hypoxic ventilatory response after two weeks of chronic hypoxia in conscious rats.
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              Text: Nov2010
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