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Cortical representations of olfactory input by trans-synaptic tracing.

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Title: Cortical representations of olfactory input by trans-synaptic tracing.
Authors: Miyamichi, Kazunari, Amat, Fernando, Moussavi, Farshid, Wang, Chen, Wickersham, Ian, Wall, Nicholas R., Taniguchi, Hiroki, Tasic, Bosiljka, Huang, Z. Josh, He, Zhigang, Callaway, Edward M., Horowitz, Mark A., Luo, Liqun
Source: Nature. 4/14/2011, Vol. 472 Issue 7342, p191-196. 6p. 3 Color Photographs, 1 Graph.
Subjects: Olfactory receptors, Laboratory mice, Mice physiology, Neural physiology, Rabies virus, Neurodegeneration, Kidney glomerulus, Amygdaloid body
Abstract: In the mouse, each class of olfactory receptor neurons expressing a given odorant receptor has convergent axonal projections to two specific glomeruli in the olfactory bulb, thereby creating an odour map. However, it is unclear how this map is represented in the olfactory cortex. Here we combine rabies-virus-dependent retrograde mono-trans-synaptic labelling with genetics to control the location, number and type of 'starter' cortical neurons, from which we trace their presynaptic neurons. We find that individual cortical neurons receive input from multiple mitral cells representing broadly distributed glomeruli. Different cortical areas represent the olfactory bulb input differently. For example, the cortical amygdala preferentially receives dorsal olfactory bulb input, whereas the piriform cortex samples the whole olfactory bulb without obvious bias. These differences probably reflect different functions of these cortical areas in mediating innate odour preference or associative memory. The trans-synaptic labelling method described here should be widely applicable to mapping connections throughout the mouse nervous system. [ABSTRACT FROM AUTHOR]
Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: <searchLink fieldCode="AR" term="%22Miyamichi%2C+Kazunari%22">Miyamichi, Kazunari</searchLink><br /><searchLink fieldCode="AR" term="%22Amat%2C+Fernando%22">Amat, Fernando</searchLink><br /><searchLink fieldCode="AR" term="%22Moussavi%2C+Farshid%22">Moussavi, Farshid</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Chen%22">Wang, Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Wickersham%2C+Ian%22">Wickersham, Ian</searchLink><br /><searchLink fieldCode="AR" term="%22Wall%2C+Nicholas+R%2E%22">Wall, Nicholas R.</searchLink><br /><searchLink fieldCode="AR" term="%22Taniguchi%2C+Hiroki%22">Taniguchi, Hiroki</searchLink><br /><searchLink fieldCode="AR" term="%22Tasic%2C+Bosiljka%22">Tasic, Bosiljka</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+Z%2E+Josh%22">Huang, Z. Josh</searchLink><br /><searchLink fieldCode="AR" term="%22He%2C+Zhigang%22">He, Zhigang</searchLink><br /><searchLink fieldCode="AR" term="%22Callaway%2C+Edward+M%2E%22">Callaway, Edward M.</searchLink><br /><searchLink fieldCode="AR" term="%22Horowitz%2C+Mark+A%2E%22">Horowitz, Mark A.</searchLink><br /><searchLink fieldCode="AR" term="%22Luo%2C+Liqun%22">Luo, Liqun</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 4/14/2011, Vol. 472 Issue 7342, p191-196. 6p. 3 Color Photographs, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Olfactory+receptors%22">Olfactory receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Mice+physiology%22">Mice physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+physiology%22">Neural physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Rabies+virus%22">Rabies virus</searchLink><br /><searchLink fieldCode="DE" term="%22Neurodegeneration%22">Neurodegeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Kidney+glomerulus%22">Kidney glomerulus</searchLink><br /><searchLink fieldCode="DE" term="%22Amygdaloid+body%22">Amygdaloid body</searchLink>
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  Data: In the mouse, each class of olfactory receptor neurons expressing a given odorant receptor has convergent axonal projections to two specific glomeruli in the olfactory bulb, thereby creating an odour map. However, it is unclear how this map is represented in the olfactory cortex. Here we combine rabies-virus-dependent retrograde mono-trans-synaptic labelling with genetics to control the location, number and type of 'starter' cortical neurons, from which we trace their presynaptic neurons. We find that individual cortical neurons receive input from multiple mitral cells representing broadly distributed glomeruli. Different cortical areas represent the olfactory bulb input differently. For example, the cortical amygdala preferentially receives dorsal olfactory bulb input, whereas the piriform cortex samples the whole olfactory bulb without obvious bias. These differences probably reflect different functions of these cortical areas in mediating innate odour preference or associative memory. The trans-synaptic labelling method described here should be widely applicable to mapping connections throughout the mouse nervous system. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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