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Effects of a CACNA1C genotype on attention networks in healthy individuals.

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Title: Effects of a CACNA1C genotype on attention networks in healthy individuals.
Authors: Thimm, M., Kircher, T., Kellermann, T., Markov, V., Krach, S., Jansen, A., Zerres, K., Eggermann, T., Stöcker, T., Shah, N. J., Nöthen, M. M., Rietschel, M., Witt, S. H., Mathiak, K., Krug, A.
Source: Psychological Medicine. Jul2011, Vol. 41 Issue 7, p1551-1561. 11p. 1 Diagram, 1 Chart, 2 Graphs.
Subjects: Brain, Radiography, Attention, DNA, Genes, Handedness, Magnetic resonance imaging, Psychoses, Research funding
Geographic Terms: Germany
Abstract: BackgroundRecent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder. In these disorders, attention deficits are among the main cognitive symptoms and have been related to altered neural activity in cerebral attention networks. The particular effect of CACNA1C on neural function, such as attention networks, remains to be elucidated.MethodThe current event-related functional magnetic resonance imaging (fMRI) study investigated the effect of the CACNA1C gene on brain activity in 80 subjects while performing a scanner-adapted version of the Attention Network Test (ANT). Three domains of attention were probed simultaneously: alerting, orienting and executive control of attention.ResultsRisk allele carriers showed impaired performance in alerting and orienting in addition to reduced neural activity in the right inferior parietal lobule [Brodmann area (BA) 40] during orienting and in the medial frontal gyrus (BA 8) during executive control of attention. These areas belong to networks that have been related to impaired orienting and executive control mechanisms in neuropsychiatric disorders.ConclusionsOur results suggest that CACNA1C plays a role in the development of specific attention deficits in psychiatric disorders by modulation of neural attention networks. [ABSTRACT FROM PUBLISHER]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Effects of a CACNA1C genotype on attention networks in healthy individuals.
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  Data: <searchLink fieldCode="AR" term="%22Thimm%2C+M%2E%22">Thimm, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Kircher%2C+T%2E%22">Kircher, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Kellermann%2C+T%2E%22">Kellermann, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Markov%2C+V%2E%22">Markov, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Krach%2C+S%2E%22">Krach, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Jansen%2C+A%2E%22">Jansen, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Zerres%2C+K%2E%22">Zerres, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Eggermann%2C+T%2E%22">Eggermann, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Stöcker%2C+T%2E%22">Stöcker, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Shah%2C+N%2E+J%2E%22">Shah, N. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Nöthen%2C+M%2E+M%2E%22">Nöthen, M. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Rietschel%2C+M%2E%22">Rietschel, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Witt%2C+S%2E+H%2E%22">Witt, S. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Mathiak%2C+K%2E%22">Mathiak, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Krug%2C+A%2E%22">Krug, A.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Jul2011, Vol. 41 Issue 7, p1551-1561. 11p. 1 Diagram, 1 Chart, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Radiography%22">Radiography</searchLink><br /><searchLink fieldCode="DE" term="%22Attention%22">Attention</searchLink><br /><searchLink fieldCode="DE" term="%22DNA%22">DNA</searchLink><br /><searchLink fieldCode="DE" term="%22Genes%22">Genes</searchLink><br /><searchLink fieldCode="DE" term="%22Handedness%22">Handedness</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink>
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  Data: BackgroundRecent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder. In these disorders, attention deficits are among the main cognitive symptoms and have been related to altered neural activity in cerebral attention networks. The particular effect of CACNA1C on neural function, such as attention networks, remains to be elucidated.MethodThe current event-related functional magnetic resonance imaging (fMRI) study investigated the effect of the CACNA1C gene on brain activity in 80 subjects while performing a scanner-adapted version of the Attention Network Test (ANT). Three domains of attention were probed simultaneously: alerting, orienting and executive control of attention.ResultsRisk allele carriers showed impaired performance in alerting and orienting in addition to reduced neural activity in the right inferior parietal lobule [Brodmann area (BA) 40] during orienting and in the medial frontal gyrus (BA 8) during executive control of attention. These areas belong to networks that have been related to impaired orienting and executive control mechanisms in neuropsychiatric disorders.ConclusionsOur results suggest that CACNA1C plays a role in the development of specific attention deficits in psychiatric disorders by modulation of neural attention networks. [ABSTRACT FROM PUBLISHER]
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=60966824
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        Value: 10.1017/S0033291710002217
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