Renal denervation abolishes the protective effects of ischaemic preconditioning on function and haemodynamics in ischaemia-reperfused rat kidneys.
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| Title: | Renal denervation abolishes the protective effects of ischaemic preconditioning on function and haemodynamics in ischaemia-reperfused rat kidneys. |
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| Authors: | OGAWA, T, MIMURA, Y, KAMINISHI, M |
| Source: | Acta Physiologica Scandinavica. Mar2002, Vol. 174 Issue 3, p291-297. 7p. |
| Subjects: | Kidney surgery, Ischemia |
| Abstract: | Studies were conducted to investigate the role of renal sympathetic nerves in the process of acquiring ischaemic tolerance in ischaemic preconditioned ischaemia-reperfused rat kidneys. Two periods of 3-min occlusion of bilateral renal arteries was performed prior to 30-min bilateral ischaemia and 90-min reperfusion in acute renal denervated or innervated kidneys. The glomerular filtration rate (GFR), fractional excretion of sodium (FENa) and lithium (FELi), and renal blood flow (RBF) were assessed in reperfused kidneys. Ischaemic preconditioning significantly improved values for all these parameters as compared with no treated ischaemia-reperfused kidneys. Denervation caused slight increase in GFR, diuresis and natriuresis without improving RBF after reperfusion. However, protecting effects of ischaemic preconditioning on renal function were disappeared in denervated kidneys, while in innevated kidneys the effects of ischaemic preconditioning were maintained. These results clearly showed that ischaemic preconditioning pre-treatment protects kidneys against ischaemia–reperfusion injury, and the effects are, at least in part, mediated by sympathetic nerves, as the protective effects were abolished by denervation. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Physiologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 6372544 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Renal denervation abolishes the protective effects of ischaemic preconditioning on function and haemodynamics in ischaemia-reperfused rat kidneys. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22OGAWA%2C+T%22">OGAWA, T</searchLink><br /><searchLink fieldCode="AR" term="%22MIMURA%2C+Y%22">MIMURA, Y</searchLink><br /><searchLink fieldCode="AR" term="%22KAMINISHI%2C+M%22">KAMINISHI, M</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica+Scandinavica%22">Acta Physiologica Scandinavica</searchLink>. Mar2002, Vol. 174 Issue 3, p291-297. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Kidney+surgery%22">Kidney surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Ischemia%22">Ischemia</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Studies were conducted to investigate the role of renal sympathetic nerves in the process of acquiring ischaemic tolerance in ischaemic preconditioned ischaemia-reperfused rat kidneys. Two periods of 3-min occlusion of bilateral renal arteries was performed prior to 30-min bilateral ischaemia and 90-min reperfusion in acute renal denervated or innervated kidneys. The glomerular filtration rate (GFR), fractional excretion of sodium (FENa) and lithium (FELi), and renal blood flow (RBF) were assessed in reperfused kidneys. Ischaemic preconditioning significantly improved values for all these parameters as compared with no treated ischaemia-reperfused kidneys. Denervation caused slight increase in GFR, diuresis and natriuresis without improving RBF after reperfusion. However, protecting effects of ischaemic preconditioning on renal function were disappeared in denervated kidneys, while in innevated kidneys the effects of ischaemic preconditioning were maintained. These results clearly showed that ischaemic preconditioning pre-treatment protects kidneys against ischaemia–reperfusion injury, and the effects are, at least in part, mediated by sympathetic nerves, as the protective effects were abolished by denervation. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Physiologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1046/j.1365-201x.2002.00944.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 291 Subjects: – SubjectFull: Kidney surgery Type: general – SubjectFull: Ischemia Type: general Titles: – TitleFull: Renal denervation abolishes the protective effects of ischaemic preconditioning on function and haemodynamics in ischaemia-reperfused rat kidneys. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: OGAWA, T – PersonEntity: Name: NameFull: MIMURA, Y – PersonEntity: Name: NameFull: KAMINISHI, M IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2002 Type: published Y: 2002 Identifiers: – Type: issn-print Value: 00016772 Numbering: – Type: volume Value: 174 – Type: issue Value: 3 Titles: – TitleFull: Acta Physiologica Scandinavica Type: main |
| ResultId | 1 |
