Clinical Efficacy of Frovatriptan: Placebo-Controlled Studies.
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| Title: | Clinical Efficacy of Frovatriptan: Placebo-Controlled Studies. |
|---|---|
| Authors: | Ryan, R, Géraud, G, Goldstein, J, Cady, R, Keywood, C |
| Source: | Headache: The Journal of Head & Face Pain. Apr2002 Supplement 2, Vol. 42, p84-92. 9p. |
| Subjects: | Serotonin, Headache treatment, Migraine |
| Abstract: | Objective.—To confirm the clinical efficacy of frovatriptan 2.5 mg. Background.—Frovatriptan is a new 5-hydroxytryptamine (5-HT)1B/1D receptor agonist being developed for the acute treatment of migraine with or without aura. Results from preclinical and clinical pharmacology studies showed frovatriptan to be a potent 5-HT1B receptor agonist with a long terminal elimination half-life (26 hours) and a broad therapeutic index. Design.—Three randomized, placebo-controlled, double-blind, parallel-group trials, in a total of 2676 patients, were performed to confirm the clinical efficacy of frovatriptan 2.5 mg for the acute treatment of migraine. Results.—In all three studies, headache response 2 hours after frovatriptan dosing was significantly greater than that seen with placebo (P <= .001) with approximately a two-fold measure of effect over placebo for headache response at 2 and 4 hours postdosing. Time to headache response occurred within 1.5 hours in a substantial proportion of patients. The incidence of 24-hour headache recurrence with frovatriptan was low (10% to 25%). Frovatriptan therapy also was associated with a high degree of patient satisfaction. Conclusions.—Frovatriptan represents a consistently effective acute treatment for migraine and accompanying symptoms. [ABSTRACT FROM AUTHOR] |
| Copyright of Headache: The Journal of Head & Face Pain is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 6698588 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Clinical Efficacy of Frovatriptan: Placebo-Controlled Studies. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ryan%2C+R%22">Ryan, R</searchLink><br /><searchLink fieldCode="AR" term="%22Géraud%2C+G%22">Géraud, G</searchLink><br /><searchLink fieldCode="AR" term="%22Goldstein%2C+J%22">Goldstein, J</searchLink><br /><searchLink fieldCode="AR" term="%22Cady%2C+R%22">Cady, R</searchLink><br /><searchLink fieldCode="AR" term="%22Keywood%2C+C%22">Keywood, C</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Headache%3A+The+Journal+of+Head+%26+Face+Pain%22">Headache: The Journal of Head & Face Pain</searchLink>. Apr2002 Supplement 2, Vol. 42, p84-92. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Serotonin%22">Serotonin</searchLink><br /><searchLink fieldCode="DE" term="%22Headache+treatment%22">Headache treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Migraine%22">Migraine</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective.—To confirm the clinical efficacy of frovatriptan 2.5 mg. Background.—Frovatriptan is a new 5-hydroxytryptamine (5-HT)1B/1D receptor agonist being developed for the acute treatment of migraine with or without aura. Results from preclinical and clinical pharmacology studies showed frovatriptan to be a potent 5-HT1B receptor agonist with a long terminal elimination half-life (26 hours) and a broad therapeutic index. Design.—Three randomized, placebo-controlled, double-blind, parallel-group trials, in a total of 2676 patients, were performed to confirm the clinical efficacy of frovatriptan 2.5 mg for the acute treatment of migraine. Results.—In all three studies, headache response 2 hours after frovatriptan dosing was significantly greater than that seen with placebo (P <= .001) with approximately a two-fold measure of effect over placebo for headache response at 2 and 4 hours postdosing. Time to headache response occurred within 1.5 hours in a substantial proportion of patients. The incidence of 24-hour headache recurrence with frovatriptan was low (10% to 25%). Frovatriptan therapy also was associated with a high degree of patient satisfaction. Conclusions.—Frovatriptan represents a consistently effective acute treatment for migraine and accompanying symptoms. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Headache: The Journal of Head & Face Pain is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=6698588 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1046/j.1526-4610.42.s2.6.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 84 Subjects: – SubjectFull: Serotonin Type: general – SubjectFull: Headache treatment Type: general – SubjectFull: Migraine Type: general Titles: – TitleFull: Clinical Efficacy of Frovatriptan: Placebo-Controlled Studies. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ryan, R – PersonEntity: Name: NameFull: Géraud, G – PersonEntity: Name: NameFull: Goldstein, J – PersonEntity: Name: NameFull: Cady, R – PersonEntity: Name: NameFull: Keywood, C IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 04 Text: Apr2002 Supplement 2 Type: published Y: 2002 Identifiers: – Type: issn-print Value: 00178748 Numbering: – Type: volume Value: 42 Titles: – TitleFull: Headache: The Journal of Head & Face Pain Type: main |
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