View in EDS HTML Full Text PDF Full Text

Primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum.

Saved in:
Bibliographic Details
Title: Primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum.
Authors: Brown, Holden D. (AUTHOR), McCutcheon, James E. (AUTHOR), Cone, Jackson J. (AUTHOR), Ragozzino, Michael E. (AUTHOR), Roitman, Mitchell F. (AUTHOR)
Source: European Journal of Neuroscience. Dec2011, Vol. 34 Issue 12, p1997-2006. 10p.
Subjects: Neural stimulation, Dopamine, Cellular signal transduction, Dopaminergic neurons, Prediction models, Material plasticity, Gene targeting, Voltammetry
Abstract: Phasic changes in dopamine activity play a critical role in learning and goal-directed behavior. Unpredicted reward and reward-predictive cues evoke phasic increases in the firing rate of the majority of midbrain dopamine neurons - results that predict uniformly broadcast increases in dopamine concentration throughout the striatum. However, measurement of dopamine concentration changes during reward has cast doubt on this prediction. We systematically measured phasic changes in dopamine in four striatal subregions [nucleus accumbens shell and core (Core), dorsomedial (DMS) and dorsolateral striatum] in response to stimuli known to activate a majority of dopamine neurons. We used fast-scan cyclic voltammetry in awake and behaving rats, which measures changes in dopamine on a similar timescale to the electrophysiological recordings that established a relationship between phasic dopamine activity and reward. Unlike the responses of midbrain dopamine neurons, unpredicted food reward and reward-predictive cues evoked a phasic increase in dopamine that was subregion specific. In rats with limited experience, unpredicted food reward evoked an increase exclusively in the Core. In rats trained on a discriminative stimulus paradigm, both unpredicted reward and reward-predictive cues evoked robust phasic dopamine in the Core and DMS. Thus, phasic dopamine release in select target structures is dynamic and dependent on context and experience. Because the four subregions assayed receive different inputs and have differential projection targets, the regional selectivity of phasic changes in dopamine has important implications for information flow through the striatum and plasticity that underlies learning and goal-directed behavior. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 69605166
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Brown%2C+Holden+D%2E%22">Brown, Holden D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McCutcheon%2C+James+E%2E%22">McCutcheon, James E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cone%2C+Jackson+J%2E%22">Cone, Jackson J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ragozzino%2C+Michael+E%2E%22">Ragozzino, Michael E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roitman%2C+Mitchell+F%2E%22">Roitman, Mitchell F.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Dec2011, Vol. 34 Issue 12, p1997-2006. 10p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Neural+stimulation%22">Neural stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink><br /><searchLink fieldCode="DE" term="%22Cellular+signal+transduction%22">Cellular signal transduction</searchLink><br /><searchLink fieldCode="DE" term="%22Dopaminergic+neurons%22">Dopaminergic neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Prediction+models%22">Prediction models</searchLink><br /><searchLink fieldCode="DE" term="%22Material+plasticity%22">Material plasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+targeting%22">Gene targeting</searchLink><br /><searchLink fieldCode="DE" term="%22Voltammetry%22">Voltammetry</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Phasic changes in dopamine activity play a critical role in learning and goal-directed behavior. Unpredicted reward and reward-predictive cues evoke phasic increases in the firing rate of the majority of midbrain dopamine neurons - results that predict uniformly broadcast increases in dopamine concentration throughout the striatum. However, measurement of dopamine concentration changes during reward has cast doubt on this prediction. We systematically measured phasic changes in dopamine in four striatal subregions [nucleus accumbens shell and core (Core), dorsomedial (DMS) and dorsolateral striatum] in response to stimuli known to activate a majority of dopamine neurons. We used fast-scan cyclic voltammetry in awake and behaving rats, which measures changes in dopamine on a similar timescale to the electrophysiological recordings that established a relationship between phasic dopamine activity and reward. Unlike the responses of midbrain dopamine neurons, unpredicted food reward and reward-predictive cues evoked a phasic increase in dopamine that was subregion specific. In rats with limited experience, unpredicted food reward evoked an increase exclusively in the Core. In rats trained on a discriminative stimulus paradigm, both unpredicted reward and reward-predictive cues evoked robust phasic dopamine in the Core and DMS. Thus, phasic dopamine release in select target structures is dynamic and dependent on context and experience. Because the four subregions assayed receive different inputs and have differential projection targets, the regional selectivity of phasic changes in dopamine has important implications for information flow through the striatum and plasticity that underlies learning and goal-directed behavior. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=69605166
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/j.1460-9568.2011.07914.x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 1997
    Subjects:
      – SubjectFull: Neural stimulation
        Type: general
      – SubjectFull: Dopamine
        Type: general
      – SubjectFull: Cellular signal transduction
        Type: general
      – SubjectFull: Dopaminergic neurons
        Type: general
      – SubjectFull: Prediction models
        Type: general
      – SubjectFull: Material plasticity
        Type: general
      – SubjectFull: Gene targeting
        Type: general
      – SubjectFull: Voltammetry
        Type: general
    Titles:
      – TitleFull: Primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Brown, Holden D.
      – PersonEntity:
          Name:
            NameFull: McCutcheon, James E.
      – PersonEntity:
          Name:
            NameFull: Cone, Jackson J.
      – PersonEntity:
          Name:
            NameFull: Ragozzino, Michael E.
      – PersonEntity:
          Name:
            NameFull: Roitman, Mitchell F.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 12
              Text: Dec2011
              Type: published
              Y: 2011
          Identifiers:
            – Type: issn-print
              Value: 0953816X
          Numbering:
            – Type: volume
              Value: 34
            – Type: issue
              Value: 12
          Titles:
            – TitleFull: European Journal of Neuroscience
              Type: main
ResultId 1