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ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry.

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Title: ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry.
Authors: Bierut, L J, Goate, A M, Breslau, N, Johnson, E O, Bertelsen, S, Fox, L, Agrawal, A, Bucholz, K K, Grucza, R, Hesselbrock, V, Kramer, J, Kuperman, S, Nurnberger, J, Porjesz, B, Saccone, N L, Schuckit, M, Tischfield, J, Wang, J C, Foroud, T, Rice, J P
Source: Molecular Psychiatry. Apr2012, Vol. 17 Issue 4, p445-450. 6p. 3 Charts, 1 Graph.
Subjects: Alcohol dehydrogenase, Alcohol drinking, Drug abuse, Mental illness, African Americans
Abstract: A coding variant in alcohol dehydrogenase 1B (ADH1B) (rs1229984) that leads to the replacement of Arg48 with His48 is common in Asian populations and reduces their risk for alcoholism, but because of very low allele frequencies the effects in European or African populations have been difficult to detect. We genotyped and analyzed this variant in three large European and African-American case-control studies in which alcohol dependence was defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria, and demonstrated a strong protective effect of the His48 variant (odds ratio (OR) 0.34, 95% confidence interval (CI) 0.24, 0.48) on alcohol dependence, with genome-wide significance (6.6 × 10-10). The hypothesized mechanism of action involves an increased aversive reaction to alcohol; in keeping with this hypothesis, the same allele is strongly associated with a lower maximum number of drinks in a 24-hour period (lifetime), with P=3 × 10-13. We also tested the effects of this allele on the development of alcoholism in adolescents and young adults, and demonstrated a significantly protective effect. This variant has the strongest effect on risk for alcohol dependence compared with any other tested variant in European populations. [ABSTRACT FROM AUTHOR]
Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry.
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  Data: <searchLink fieldCode="AR" term="%22Bierut%2C+L+J%22">Bierut, L J</searchLink><br /><searchLink fieldCode="AR" term="%22Goate%2C+A+M%22">Goate, A M</searchLink><br /><searchLink fieldCode="AR" term="%22Breslau%2C+N%22">Breslau, N</searchLink><br /><searchLink fieldCode="AR" term="%22Johnson%2C+E+O%22">Johnson, E O</searchLink><br /><searchLink fieldCode="AR" term="%22Bertelsen%2C+S%22">Bertelsen, S</searchLink><br /><searchLink fieldCode="AR" term="%22Fox%2C+L%22">Fox, L</searchLink><br /><searchLink fieldCode="AR" term="%22Agrawal%2C+A%22">Agrawal, A</searchLink><br /><searchLink fieldCode="AR" term="%22Bucholz%2C+K+K%22">Bucholz, K K</searchLink><br /><searchLink fieldCode="AR" term="%22Grucza%2C+R%22">Grucza, R</searchLink><br /><searchLink fieldCode="AR" term="%22Hesselbrock%2C+V%22">Hesselbrock, V</searchLink><br /><searchLink fieldCode="AR" term="%22Kramer%2C+J%22">Kramer, J</searchLink><br /><searchLink fieldCode="AR" term="%22Kuperman%2C+S%22">Kuperman, S</searchLink><br /><searchLink fieldCode="AR" term="%22Nurnberger%2C+J%22">Nurnberger, J</searchLink><br /><searchLink fieldCode="AR" term="%22Porjesz%2C+B%22">Porjesz, B</searchLink><br /><searchLink fieldCode="AR" term="%22Saccone%2C+N+L%22">Saccone, N L</searchLink><br /><searchLink fieldCode="AR" term="%22Schuckit%2C+M%22">Schuckit, M</searchLink><br /><searchLink fieldCode="AR" term="%22Tischfield%2C+J%22">Tischfield, J</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+J+C%22">Wang, J C</searchLink><br /><searchLink fieldCode="AR" term="%22Foroud%2C+T%22">Foroud, T</searchLink><br /><searchLink fieldCode="AR" term="%22Rice%2C+J+P%22">Rice, J P</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. Apr2012, Vol. 17 Issue 4, p445-450. 6p. 3 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Alcohol+dehydrogenase%22">Alcohol dehydrogenase</searchLink><br /><searchLink fieldCode="DE" term="%22Alcohol+drinking%22">Alcohol drinking</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+abuse%22">Drug abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+illness%22">Mental illness</searchLink><br /><searchLink fieldCode="DE" term="%22African+Americans%22">African Americans</searchLink>
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  Data: A coding variant in alcohol dehydrogenase 1B (ADH1B) (rs1229984) that leads to the replacement of Arg48 with His48 is common in Asian populations and reduces their risk for alcoholism, but because of very low allele frequencies the effects in European or African populations have been difficult to detect. We genotyped and analyzed this variant in three large European and African-American case-control studies in which alcohol dependence was defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria, and demonstrated a strong protective effect of the His48 variant (odds ratio (OR) 0.34, 95% confidence interval (CI) 0.24, 0.48) on alcohol dependence, with genome-wide significance (6.6 × 10-10). The hypothesized mechanism of action involves an increased aversive reaction to alcohol; in keeping with this hypothesis, the same allele is strongly associated with a lower maximum number of drinks in a 24-hour period (lifetime), with P=3 × 10-13. We also tested the effects of this allele on the development of alcoholism in adolescents and young adults, and demonstrated a significantly protective effect. This variant has the strongest effect on risk for alcohol dependence compared with any other tested variant in European populations. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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