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Brain vulnerability to chemotherapy toxicities Brain vulnerability to chemotherapy toxicities.

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Title: Brain vulnerability to chemotherapy toxicities Brain vulnerability to chemotherapy toxicities.
Authors: Ahles, Tim A. (AUTHOR)
Source: Psycho-Oncology. Nov2012, Vol. 21 Issue 11, p1141-1148. 8p. 2 Graphs.
Subjects: Drug side effects, Cancer treatment complications, Drug toxicity, Adjuvant treatment of cancer, Breast cancer patients, Laboratory animals
Abstract: Chemotherapy-induced cognitive changes have been an increasing concern among cancer survivors. By using adjuvant treatment for breast cancer as the prototype, this manuscript reviews research from neuropsychological, imaging, genetic, and animal model studies that have examined the clinical presentation and potential mechanisms for cognitive changes associated with exposure to chemotherapy. An impressive body of research supports the hypothesis that a subgroup of patients is vulnerable to post-treatment cognitive changes, although not exclusively related to chemotherapy. Further, imaging and animal model studies provide accumulating evidence of putative mechanisms for chemotherapy-induced cognitive change. Models of aging are also reviewed in support of the proposal that cognitive changes associated with cancer and cancer treatments can be viewed in the context of factors that affect the trajectory of normal aging. Copyright © 2012 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Copyright of Psycho-Oncology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Brain vulnerability to chemotherapy toxicities Brain vulnerability to chemotherapy toxicities.
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  Data: <searchLink fieldCode="DE" term="%22Drug+side+effects%22">Drug side effects</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+treatment+complications%22">Cancer treatment complications</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+toxicity%22">Drug toxicity</searchLink><br /><searchLink fieldCode="DE" term="%22Adjuvant+treatment+of+cancer%22">Adjuvant treatment of cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Breast+cancer+patients%22">Breast cancer patients</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+animals%22">Laboratory animals</searchLink>
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  Data: Chemotherapy-induced cognitive changes have been an increasing concern among cancer survivors. By using adjuvant treatment for breast cancer as the prototype, this manuscript reviews research from neuropsychological, imaging, genetic, and animal model studies that have examined the clinical presentation and potential mechanisms for cognitive changes associated with exposure to chemotherapy. An impressive body of research supports the hypothesis that a subgroup of patients is vulnerable to post-treatment cognitive changes, although not exclusively related to chemotherapy. Further, imaging and animal model studies provide accumulating evidence of putative mechanisms for chemotherapy-induced cognitive change. Models of aging are also reviewed in support of the proposal that cognitive changes associated with cancer and cancer treatments can be viewed in the context of factors that affect the trajectory of normal aging. Copyright © 2012 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psycho-Oncology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/pon.3196
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        Text: English
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      – SubjectFull: Drug toxicity
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      – SubjectFull: Adjuvant treatment of cancer
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      – SubjectFull: Breast cancer patients
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      – TitleFull: Brain vulnerability to chemotherapy toxicities Brain vulnerability to chemotherapy toxicities.
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              Text: Nov2012
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