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The PRIPS study: screening battery for subjects at risk for Parkinson's disease.

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Title: The PRIPS study: screening battery for subjects at risk for Parkinson's disease.
Authors: Berg, D., Godau, J., Seppi, K., Behnke, S., Liepelt‐Scarfone, I., Lerche, S., Stockner, H., Gaenslen, A., Mahlknecht, P., Huber, H., Srulijes, K., Klenk, J., Fassbender, K., Maetzler, W., Poewe, W.
Source: European Journal of Neurology. Jan2013, Vol. 20 Issue 1, p102-108. 7p. 1 Diagram, 4 Charts.
Subjects: Parkinson's disease & genetics, Genetic testing, Substantia nigra, Family history (Medicine), Genetic disorder diagnosis
Abstract: Background and purpose Screening batteries to narrow down a target-at-risk population are essential for trials testing neuroprotective compounds aiming to delay or prevent onset of Parkinson's disease (PD). Methods The PRIPS study focuses on early detection of incident PD in 1847 at baseline PD-free subjects, and assessed age, male gender, positive family history, hyposmia, subtle motor impairment and enlarged substantia nigra hyperechogenicity (SN+). Results After 3 years follow-up 11 subjects had developed PD. In this analysis of the secondary outcome parameters, sensitivity and specificity of baseline markers for incident PD were calculated in 1352 subjects with complete datasets (10 PD patients). The best approach for prediction of incident PD comprised three steps: (i) prescreening for age, (ii) primary screening for positive family history and/or hyposmia, and (iii) secondary screening for SN+. Conclusion With this approach, one out of 16 positively screened participants developed PD compared to one out of 135 in the original cohort. This corresponds to a sensitivity of 80.0%, a specificity of 90.6% and a positive predictive value of 6.1%. These values are higher than for any single screening instrument but still too low for a feasible and cost-effective screening strategy which might require longer follow-up intervals and application of additional instruments. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: The PRIPS study: screening battery for subjects at risk for Parkinson's disease.
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  Data: <searchLink fieldCode="AR" term="%22Berg%2C+D%2E%22">Berg, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Godau%2C+J%2E%22">Godau, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Seppi%2C+K%2E%22">Seppi, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Behnke%2C+S%2E%22">Behnke, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Liepelt‐Scarfone%2C+I%2E%22">Liepelt‐Scarfone, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Lerche%2C+S%2E%22">Lerche, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Stockner%2C+H%2E%22">Stockner, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Gaenslen%2C+A%2E%22">Gaenslen, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Mahlknecht%2C+P%2E%22">Mahlknecht, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Huber%2C+H%2E%22">Huber, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Srulijes%2C+K%2E%22">Srulijes, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Klenk%2C+J%2E%22">Klenk, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Fassbender%2C+K%2E%22">Fassbender, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Maetzler%2C+W%2E%22">Maetzler, W.</searchLink><br /><searchLink fieldCode="AR" term="%22Poewe%2C+W%2E%22">Poewe, W.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Jan2013, Vol. 20 Issue 1, p102-108. 7p. 1 Diagram, 4 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease+%26+genetics%22">Parkinson's disease & genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+testing%22">Genetic testing</searchLink><br /><searchLink fieldCode="DE" term="%22Substantia+nigra%22">Substantia nigra</searchLink><br /><searchLink fieldCode="DE" term="%22Family+history+%28Medicine%29%22">Family history (Medicine)</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+disorder+diagnosis%22">Genetic disorder diagnosis</searchLink>
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  Data: Background and purpose Screening batteries to narrow down a target-at-risk population are essential for trials testing neuroprotective compounds aiming to delay or prevent onset of Parkinson's disease (PD). Methods The PRIPS study focuses on early detection of incident PD in 1847 at baseline PD-free subjects, and assessed age, male gender, positive family history, hyposmia, subtle motor impairment and enlarged substantia nigra hyperechogenicity (SN+). Results After 3 years follow-up 11 subjects had developed PD. In this analysis of the secondary outcome parameters, sensitivity and specificity of baseline markers for incident PD were calculated in 1352 subjects with complete datasets (10 PD patients). The best approach for prediction of incident PD comprised three steps: (i) prescreening for age, (ii) primary screening for positive family history and/or hyposmia, and (iii) secondary screening for SN+. Conclusion With this approach, one out of 16 positively screened participants developed PD compared to one out of 135 in the original cohort. This corresponds to a sensitivity of 80.0%, a specificity of 90.6% and a positive predictive value of 6.1%. These values are higher than for any single screening instrument but still too low for a feasible and cost-effective screening strategy which might require longer follow-up intervals and application of additional instruments. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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