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Do systolic BP and pulse pressure relate to ventricular enlargement?

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Title: Do systolic BP and pulse pressure relate to ventricular enlargement?
Authors: Graff‐Radford, N. R., Knopman, D. S., Penman, A. D., Coker, L. H., Mosley, T. H.
Source: European Journal of Neurology. Apr2013, Vol. 20 Issue 4, p720-724. 5p. 3 Charts.
Subjects: Systolic blood pressure, Pulse measurement, Heart ventricle diseases, Logistic regression analysis, Hydrocephalus, Laboratory animals, Hypertension, Hypotension, Disease risk factors
Abstract: Background and purpose To evaluate the association between systolic, diastolic and pulse pressure, and increase in ventricular size (VS). Observations in laboratory animals suggest intraventricular pulse pressure (systolic-diastolic) may play a role in ventricular enlargement. Methods Initial magnetic resonance ( MR) scans and vascular risk factors evaluation were performed in 1812 Atherosclerosis Risk in Communities participants in 1994-1995. In 2004-2006, 1130 participants underwent repeat MR. VS was rated using a validated nine-point scale. Multiple logistic regression analysis assessed association between blood pressure measures and pulse pressure, and the change between the MR scans of VS controlling for age, sex and race. Results At baseline 1112 participants (385 black women, 200 black men, 304 white women and 223 white men) had a mean age of 61.7 ± 4.3 years. In adjusted models pulse pressure at baseline was associated with an increase in VS [odds ratio (OR) 1.19, 95% confidence interval ( CI) 1.01-1.40], as was systolic pressure ( OR 1.28, 95% CI 1.03-1.58). Conclusions Systolic pressure and pulse pressure are associated with future development of increased VS. The findings are consistent with the animal literature that increased pulse pressure predisposes to risk of future increased VS. High pulse pressure might play a role in the pathogenesis of normal pressure hydrocephalus. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Do systolic BP and pulse pressure relate to ventricular enlargement?
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  Data: <searchLink fieldCode="AR" term="%22Graff‐Radford%2C+N%2E+R%2E%22">Graff‐Radford, N. R.</searchLink><br /><searchLink fieldCode="AR" term="%22Knopman%2C+D%2E+S%2E%22">Knopman, D. S.</searchLink><br /><searchLink fieldCode="AR" term="%22Penman%2C+A%2E+D%2E%22">Penman, A. D.</searchLink><br /><searchLink fieldCode="AR" term="%22Coker%2C+L%2E+H%2E%22">Coker, L. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Mosley%2C+T%2E+H%2E%22">Mosley, T. H.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Apr2013, Vol. 20 Issue 4, p720-724. 5p. 3 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Systolic+blood+pressure%22">Systolic blood pressure</searchLink><br /><searchLink fieldCode="DE" term="%22Pulse+measurement%22">Pulse measurement</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+ventricle+diseases%22">Heart ventricle diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Logistic+regression+analysis%22">Logistic regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrocephalus%22">Hydrocephalus</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+animals%22">Laboratory animals</searchLink><br /><searchLink fieldCode="DE" term="%22Hypertension%22">Hypertension</searchLink><br /><searchLink fieldCode="DE" term="%22Hypotension%22">Hypotension</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink>
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  Data: Background and purpose To evaluate the association between systolic, diastolic and pulse pressure, and increase in ventricular size (VS). Observations in laboratory animals suggest intraventricular pulse pressure (systolic-diastolic) may play a role in ventricular enlargement. Methods Initial magnetic resonance ( MR) scans and vascular risk factors evaluation were performed in 1812 Atherosclerosis Risk in Communities participants in 1994-1995. In 2004-2006, 1130 participants underwent repeat MR. VS was rated using a validated nine-point scale. Multiple logistic regression analysis assessed association between blood pressure measures and pulse pressure, and the change between the MR scans of VS controlling for age, sex and race. Results At baseline 1112 participants (385 black women, 200 black men, 304 white women and 223 white men) had a mean age of 61.7 ± 4.3 years. In adjusted models pulse pressure at baseline was associated with an increase in VS [odds ratio (OR) 1.19, 95% confidence interval ( CI) 1.01-1.40], as was systolic pressure ( OR 1.28, 95% CI 1.03-1.58). Conclusions Systolic pressure and pulse pressure are associated with future development of increased VS. The findings are consistent with the animal literature that increased pulse pressure predisposes to risk of future increased VS. High pulse pressure might play a role in the pathogenesis of normal pressure hydrocephalus. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ene.12067
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        Text: English
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      – SubjectFull: Pulse measurement
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      – SubjectFull: Heart ventricle diseases
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      – SubjectFull: Logistic regression analysis
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      – SubjectFull: Hydrocephalus
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      – SubjectFull: Laboratory animals
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      – SubjectFull: Hypertension
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      – SubjectFull: Disease risk factors
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      – TitleFull: Do systolic BP and pulse pressure relate to ventricular enlargement?
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            NameFull: Graff‐Radford, N. R.
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              Text: Apr2013
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