The superiority of antidepressant medication to cognitive behavior therapy in melancholic depressed patients: a 12-week single-blind randomized study.
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| Title: | The superiority of antidepressant medication to cognitive behavior therapy in melancholic depressed patients: a 12-week single-blind randomized study. |
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| Authors: | Parker, G., Blanch, B., Paterson, A., Hadzi‐Pavlovic, D., Sheppard, E., Manicavasagar, V., Synnott, H., Graham, R. K., Friend, P., Gilfillan, D., Perich, T. |
| Source: | Acta Psychiatrica Scandinavica. Oct2013, Vol. 128 Issue 4, p271-281. 11p. 1 Diagram, 2 Charts, 2 Graphs. |
| Subjects: | Mental depression, Antidepressants, Psychotherapy, Cognitive therapy, Serotonin uptake inhibitors |
| Abstract: | Objective To pursue the previously long-standing but formally untested clinical view that melancholia is preferentially responsive to antidepressant medication in comparison with psychotherapy [specifically Cognitive Behavior Therapy ( CBT)]. Second, to determine whether a broader action antidepressant medication sequencing regimen is superior to a Selective Serotonin Reuptake Inhibitor ( SSRI) alone. Method We sought to recruit a large sample of participants with melancholic depression for a 12-week trial but inclusion criteria compromised recruitment and testing the second hypothesis. The first hypothesis was evaluated by comparing 18 participants receiving antidepressant medication to 11 receiving CBT. Primary study measures were the Hamilton Rating Scale for Depression ( HAM-D) and the Hamilton Endogenous Subscale ( HES), rated blindly, while several secondary measures also evaluated outcome. Results Participants receiving medication had a superior 12-week outcome to those receiving CBT, with significant differences present on primary measures as early as 4 weeks. At trial conclusion, the percentage improvement in HAM-D scores was 61.1% vs. 34.4%, respectively [Number Needed to Treat ( NNT) = 3.7] and with those in receipt of medication returning non-significantly higher HAM-D responder (66.6% vs. 36.4%, NNT = 2.8) and remission (66.7% vs. 45.4%, NNT = 4.7) rates. Conclusion As the sample size was small and participants evidenced only moderate levels of depression severity, the study risked being underpowered and idiosyncratic. Despite the small sample, the superiority of antidepressant medication to CBT in those with a melancholic depression was distinctive in this pilot study. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 90466429 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The superiority of antidepressant medication to cognitive behavior therapy in melancholic depressed patients: a 12-week single-blind randomized study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Parker%2C+G%2E%22">Parker, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Blanch%2C+B%2E%22">Blanch, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Paterson%2C+A%2E%22">Paterson, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Hadzi‐Pavlovic%2C+D%2E%22">Hadzi‐Pavlovic, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Sheppard%2C+E%2E%22">Sheppard, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Manicavasagar%2C+V%2E%22">Manicavasagar, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Synnott%2C+H%2E%22">Synnott, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Graham%2C+R%2E+K%2E%22">Graham, R. K.</searchLink><br /><searchLink fieldCode="AR" term="%22Friend%2C+P%2E%22">Friend, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Gilfillan%2C+D%2E%22">Gilfillan, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Perich%2C+T%2E%22">Perich, T.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Oct2013, Vol. 128 Issue 4, p271-281. 11p. 1 Diagram, 2 Charts, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Psychotherapy%22">Psychotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+therapy%22">Cognitive therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin+uptake+inhibitors%22">Serotonin uptake inhibitors</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective To pursue the previously long-standing but formally untested clinical view that melancholia is preferentially responsive to antidepressant medication in comparison with psychotherapy [specifically Cognitive Behavior Therapy ( CBT)]. Second, to determine whether a broader action antidepressant medication sequencing regimen is superior to a Selective Serotonin Reuptake Inhibitor ( SSRI) alone. Method We sought to recruit a large sample of participants with melancholic depression for a 12-week trial but inclusion criteria compromised recruitment and testing the second hypothesis. The first hypothesis was evaluated by comparing 18 participants receiving antidepressant medication to 11 receiving CBT. Primary study measures were the Hamilton Rating Scale for Depression ( HAM-D) and the Hamilton Endogenous Subscale ( HES), rated blindly, while several secondary measures also evaluated outcome. Results Participants receiving medication had a superior 12-week outcome to those receiving CBT, with significant differences present on primary measures as early as 4 weeks. At trial conclusion, the percentage improvement in HAM-D scores was 61.1% vs. 34.4%, respectively [Number Needed to Treat ( NNT) = 3.7] and with those in receipt of medication returning non-significantly higher HAM-D responder (66.6% vs. 36.4%, NNT = 2.8) and remission (66.7% vs. 45.4%, NNT = 4.7) rates. Conclusion As the sample size was small and participants evidenced only moderate levels of depression severity, the study risked being underpowered and idiosyncratic. Despite the small sample, the superiority of antidepressant medication to CBT in those with a melancholic depression was distinctive in this pilot study. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=90466429 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/acps.12049 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 271 Subjects: – SubjectFull: Mental depression Type: general – SubjectFull: Antidepressants Type: general – SubjectFull: Psychotherapy Type: general – SubjectFull: Cognitive therapy Type: general – SubjectFull: Serotonin uptake inhibitors Type: general Titles: – TitleFull: The superiority of antidepressant medication to cognitive behavior therapy in melancholic depressed patients: a 12-week single-blind randomized study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Parker, G. – PersonEntity: Name: NameFull: Blanch, B. – PersonEntity: Name: NameFull: Paterson, A. – PersonEntity: Name: NameFull: Hadzi‐Pavlovic, D. – PersonEntity: Name: NameFull: Sheppard, E. – PersonEntity: Name: NameFull: Manicavasagar, V. – PersonEntity: Name: NameFull: Synnott, H. – PersonEntity: Name: NameFull: Graham, R. K. – PersonEntity: Name: NameFull: Friend, P. – PersonEntity: Name: NameFull: Gilfillan, D. – PersonEntity: Name: NameFull: Perich, T. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 0001690X Numbering: – Type: volume Value: 128 – Type: issue Value: 4 Titles: – TitleFull: Acta Psychiatrica Scandinavica Type: main |
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