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Visual cortex organisation in a macaque monkey with macular degeneration.

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Title: Visual cortex organisation in a macaque monkey with macular degeneration.
Authors: Shao, Yibin, Keliris, Georgios A., Papanikolaou, Amalia, Fischer, M. Dominik, Zobor, Ditta, Jägle, Herbert, Logothetis, Nikos K., Smirnakis, Stelios M.
Source: European Journal of Neuroscience. Nov2013, Vol. 38 Issue 10, p3456-3464. 9p.
Subjects: Visual cortex, Macaques, Retinal degeneration, Visual fields, Functional magnetic resonance imaging, Receptive fields (Neurology), Neurosciences
Abstract: The visual field is retinotopically represented in early visual areas. It has been suggested that when adult primary visual cortex (V1) is deprived of normal retinal input it is capable of large-scale reorganisation, with neurons inside the lesion projection zone (LPZ) being visually driven by inputs from intact retinal regions. Early functional magnetic resonance imaging ( fMRI) studies in humans with macular degeneration (MD) report > 1 cm spread of activity inside the LPZ border, whereas recent results report no shift of the LPZ border. Here, we used fMRI population receptive field measurements to study, for the first time, the visual cortex organisation of one macaque monkey with MD and to compare it with normal controls. Our results showed that the border of the V1 LPZ remained stable, suggesting that the deafferented area V1 zone of the MD animal has limited capacity for reorganisation. Interestingly, the pRF size of non-deafferented V1 voxels increased slightly (~20% on average), although this effect appears weaker than that in previous single-unit recording reports. Area V2 also showed limited reorganisation. Remarkably, area V5/MT of the MD animal showed extensive activation compared to controls stimulated over the part of the visual field that was spared in the MD animal. Furthermore, population receptive field size distributions differed markedly in area V5/MT of the MD animal. Taken together, these results suggest that V5/MT has a higher potential for reorganisation after MD than earlier visual cortex. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Visual cortex organisation in a macaque monkey with macular degeneration.
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  Data: <searchLink fieldCode="AR" term="%22Shao%2C+Yibin%22">Shao, Yibin</searchLink><br /><searchLink fieldCode="AR" term="%22Keliris%2C+Georgios+A%2E%22">Keliris, Georgios A.</searchLink><br /><searchLink fieldCode="AR" term="%22Papanikolaou%2C+Amalia%22">Papanikolaou, Amalia</searchLink><br /><searchLink fieldCode="AR" term="%22Fischer%2C+M%2E+Dominik%22">Fischer, M. Dominik</searchLink><br /><searchLink fieldCode="AR" term="%22Zobor%2C+Ditta%22">Zobor, Ditta</searchLink><br /><searchLink fieldCode="AR" term="%22Jägle%2C+Herbert%22">Jägle, Herbert</searchLink><br /><searchLink fieldCode="AR" term="%22Logothetis%2C+Nikos+K%2E%22">Logothetis, Nikos K.</searchLink><br /><searchLink fieldCode="AR" term="%22Smirnakis%2C+Stelios+M%2E%22">Smirnakis, Stelios M.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Nov2013, Vol. 38 Issue 10, p3456-3464. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Visual+cortex%22">Visual cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Macaques%22">Macaques</searchLink><br /><searchLink fieldCode="DE" term="%22Retinal+degeneration%22">Retinal degeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Visual+fields%22">Visual fields</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Receptive+fields+%28Neurology%29%22">Receptive fields (Neurology)</searchLink><br /><searchLink fieldCode="DE" term="%22Neurosciences%22">Neurosciences</searchLink>
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  Data: The visual field is retinotopically represented in early visual areas. It has been suggested that when adult primary visual cortex (V1) is deprived of normal retinal input it is capable of large-scale reorganisation, with neurons inside the lesion projection zone (LPZ) being visually driven by inputs from intact retinal regions. Early functional magnetic resonance imaging ( fMRI) studies in humans with macular degeneration (MD) report > 1 cm spread of activity inside the LPZ border, whereas recent results report no shift of the LPZ border. Here, we used fMRI population receptive field measurements to study, for the first time, the visual cortex organisation of one macaque monkey with MD and to compare it with normal controls. Our results showed that the border of the V1 LPZ remained stable, suggesting that the deafferented area V1 zone of the MD animal has limited capacity for reorganisation. Interestingly, the pRF size of non-deafferented V1 voxels increased slightly (~20% on average), although this effect appears weaker than that in previous single-unit recording reports. Area V2 also showed limited reorganisation. Remarkably, area V5/MT of the MD animal showed extensive activation compared to controls stimulated over the part of the visual field that was spared in the MD animal. Furthermore, population receptive field size distributions differed markedly in area V5/MT of the MD animal. Taken together, these results suggest that V5/MT has a higher potential for reorganisation after MD than earlier visual cortex. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=92005421
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        Value: 10.1111/ejn.12349
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      – TitleFull: Visual cortex organisation in a macaque monkey with macular degeneration.
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              Text: Nov2013
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              Y: 2013
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