Hepatitis C Virus E2 Envelope Glycoprotein Core Structure.
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| Title: | Hepatitis C Virus E2 Envelope Glycoprotein Core Structure. |
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| Authors: | Leopold Kong, Giang, Erick, Nieusma, Travis, Kadam, Rameshwar U., Cogburn, Kristin E., Yuanzi Hua, Xiaoping Dai, Stanfield, Robyn L., Burton, Dennis R., Ward, Andrew B., Wilson, Ian A., Mansun Law |
| Source: | Science (pre-March 2025). 11/29/2013, Vol. 342 Issue 6162, p1090-1094. 5p. |
| Subjects: | Treatment of cirrhosis of the liver, Hepatitis C virus, Glycoproteins, Protein structure, Immune response, Electron microscopy, Drug design |
| Abstract: | Hepatitis C virus (HCV), a Hepacivirus, is a major cause of viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. HCV envelope glycoproteins E1 and E2 mediate fusion and entry into host cells and are the primary targets of the humoral immune response. The crystal structure of the E2 core bound to broadly neutralizing antibody AR3C at 2.65 angstroms reveals a compact architecture composed of a central immunoglobulin-fold b sandwich flanked by two additional protein layers. The CD81 receptor binding site was identified by electron microscopy and site-directed mutagenesis and overlaps with the AR3C epitope. The x-ray and electron microscopy E2 structures differ markedly from predictions of an extended, three-domain, class II fusion protein fold and therefore provide valuable information for HCV drug and vaccine design. [ABSTRACT FROM AUTHOR] |
| Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 92711964 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Hepatitis C Virus E2 Envelope Glycoprotein Core Structure. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Leopold+Kong%22">Leopold Kong</searchLink><br /><searchLink fieldCode="AR" term="%22Giang%2C+Erick%22">Giang, Erick</searchLink><br /><searchLink fieldCode="AR" term="%22Nieusma%2C+Travis%22">Nieusma, Travis</searchLink><br /><searchLink fieldCode="AR" term="%22Kadam%2C+Rameshwar+U%2E%22">Kadam, Rameshwar U.</searchLink><br /><searchLink fieldCode="AR" term="%22Cogburn%2C+Kristin+E%2E%22">Cogburn, Kristin E.</searchLink><br /><searchLink fieldCode="AR" term="%22Yuanzi+Hua%22">Yuanzi Hua</searchLink><br /><searchLink fieldCode="AR" term="%22Xiaoping+Dai%22">Xiaoping Dai</searchLink><br /><searchLink fieldCode="AR" term="%22Stanfield%2C+Robyn+L%2E%22">Stanfield, Robyn L.</searchLink><br /><searchLink fieldCode="AR" term="%22Burton%2C+Dennis+R%2E%22">Burton, Dennis R.</searchLink><br /><searchLink fieldCode="AR" term="%22Ward%2C+Andrew+B%2E%22">Ward, Andrew B.</searchLink><br /><searchLink fieldCode="AR" term="%22Wilson%2C+Ian+A%2E%22">Wilson, Ian A.</searchLink><br /><searchLink fieldCode="AR" term="%22Mansun+Law%22">Mansun Law</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 11/29/2013, Vol. 342 Issue 6162, p1090-1094. 5p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Treatment+of+cirrhosis+of+the+liver%22">Treatment of cirrhosis of the liver</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatitis+C+virus%22">Hepatitis C virus</searchLink><br /><searchLink fieldCode="DE" term="%22Glycoproteins%22">Glycoproteins</searchLink><br /><searchLink fieldCode="DE" term="%22Protein+structure%22">Protein structure</searchLink><br /><searchLink fieldCode="DE" term="%22Immune+response%22">Immune response</searchLink><br /><searchLink fieldCode="DE" term="%22Electron+microscopy%22">Electron microscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+design%22">Drug design</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Hepatitis C virus (HCV), a Hepacivirus, is a major cause of viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. HCV envelope glycoproteins E1 and E2 mediate fusion and entry into host cells and are the primary targets of the humoral immune response. The crystal structure of the E2 core bound to broadly neutralizing antibody AR3C at 2.65 angstroms reveals a compact architecture composed of a central immunoglobulin-fold b sandwich flanked by two additional protein layers. The CD81 receptor binding site was identified by electron microscopy and site-directed mutagenesis and overlaps with the AR3C epitope. The x-ray and electron microscopy E2 structures differ markedly from predictions of an extended, three-domain, class II fusion protein fold and therefore provide valuable information for HCV drug and vaccine design. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1126/science.1243876 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 1090 Subjects: – SubjectFull: Treatment of cirrhosis of the liver Type: general – SubjectFull: Hepatitis C virus Type: general – SubjectFull: Glycoproteins Type: general – SubjectFull: Protein structure Type: general – SubjectFull: Immune response Type: general – SubjectFull: Electron microscopy Type: general – SubjectFull: Drug design Type: general Titles: – TitleFull: Hepatitis C Virus E2 Envelope Glycoprotein Core Structure. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Leopold Kong – PersonEntity: Name: NameFull: Giang, Erick – PersonEntity: Name: NameFull: Nieusma, Travis – PersonEntity: Name: NameFull: Kadam, Rameshwar U. – PersonEntity: Name: NameFull: Cogburn, Kristin E. – PersonEntity: Name: NameFull: Yuanzi Hua – PersonEntity: Name: NameFull: Xiaoping Dai – PersonEntity: Name: NameFull: Stanfield, Robyn L. – PersonEntity: Name: NameFull: Burton, Dennis R. – PersonEntity: Name: NameFull: Ward, Andrew B. – PersonEntity: Name: NameFull: Wilson, Ian A. – PersonEntity: Name: NameFull: Mansun Law IsPartOfRelationships: – BibEntity: Dates: – D: 29 M: 11 Text: 11/29/2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 00368075 Numbering: – Type: volume Value: 342 – Type: issue Value: 6162 Titles: – TitleFull: Science (pre-March 2025) Type: main |
| ResultId | 1 |
