Dlk1 Promotes a Fast Motor Neuron Biophysical Signature Required for Peak Force Execution.
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| Title: | Dlk1 Promotes a Fast Motor Neuron Biophysical Signature Required for Peak Force Execution. |
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| Authors: | Müller, Daniel, Cherukuri, Pitchaiah, Henningfeld, Kristine, Chor Hoon Poh, Wittler, Lars, Grote, Phillip, Schlüter, Oliver, Schmidt, Jennifer, Laborda, Jorge, Bauer, Steven R., Brownstone, Robert M., Marquardt, Till |
| Source: | Science (pre-March 2025). 3/14/2014, Vol. 343 Issue 6176, p1264-1266. 3p. |
| Subjects: | Motor neurons, Ligands (Biochemistry), Muscle motility, Notch protein genetics, Animal mechanics |
| Abstract: | Motor neurons, which relay neural commands to drive skeletal muscle movements, encompass types ranging from "slow" to "fast," whose biophysical properties govern the timing, gradation, and amplitude of muscle force. Here we identify the noncanonical Notch ligand Delta-like homolog 1 (Dlk1) as a determinant of motor neuron functional diversification. Dlk1, expressed by ~30% of motor neurons, is necessary and sufficient to promote a fast biophysical signature in the mouse and chick. Dlk1 suppresses Notch signaling and activates expression of the K+ channel subunit Kcng4 to modulate delayed-rectifier currents. Dlk1 inactivation comprehensively shifts motor neurons toward slow biophysical and transcriptome signatures, while abolishing peak force outputs. Our findings provide insights into the development of motor neuron functional diversity and its contribution to the execution of movements. [ABSTRACT FROM AUTHOR] |
| Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 94969987 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Dlk1 Promotes a Fast Motor Neuron Biophysical Signature Required for Peak Force Execution. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Müller%2C+Daniel%22">Müller, Daniel</searchLink><br /><searchLink fieldCode="AR" term="%22Cherukuri%2C+Pitchaiah%22">Cherukuri, Pitchaiah</searchLink><br /><searchLink fieldCode="AR" term="%22Henningfeld%2C+Kristine%22">Henningfeld, Kristine</searchLink><br /><searchLink fieldCode="AR" term="%22Chor+Hoon+Poh%22">Chor Hoon Poh</searchLink><br /><searchLink fieldCode="AR" term="%22Wittler%2C+Lars%22">Wittler, Lars</searchLink><br /><searchLink fieldCode="AR" term="%22Grote%2C+Phillip%22">Grote, Phillip</searchLink><br /><searchLink fieldCode="AR" term="%22Schlüter%2C+Oliver%22">Schlüter, Oliver</searchLink><br /><searchLink fieldCode="AR" term="%22Schmidt%2C+Jennifer%22">Schmidt, Jennifer</searchLink><br /><searchLink fieldCode="AR" term="%22Laborda%2C+Jorge%22">Laborda, Jorge</searchLink><br /><searchLink fieldCode="AR" term="%22Bauer%2C+Steven+R%2E%22">Bauer, Steven R.</searchLink><br /><searchLink fieldCode="AR" term="%22Brownstone%2C+Robert+M%2E%22">Brownstone, Robert M.</searchLink><br /><searchLink fieldCode="AR" term="%22Marquardt%2C+Till%22">Marquardt, Till</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 3/14/2014, Vol. 343 Issue 6176, p1264-1266. 3p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Motor+neurons%22">Motor neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Ligands+%28Biochemistry%29%22">Ligands (Biochemistry)</searchLink><br /><searchLink fieldCode="DE" term="%22Muscle+motility%22">Muscle motility</searchLink><br /><searchLink fieldCode="DE" term="%22Notch+protein+genetics%22">Notch protein genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+mechanics%22">Animal mechanics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Motor neurons, which relay neural commands to drive skeletal muscle movements, encompass types ranging from "slow" to "fast," whose biophysical properties govern the timing, gradation, and amplitude of muscle force. Here we identify the noncanonical Notch ligand Delta-like homolog 1 (Dlk1) as a determinant of motor neuron functional diversification. Dlk1, expressed by ~30% of motor neurons, is necessary and sufficient to promote a fast biophysical signature in the mouse and chick. Dlk1 suppresses Notch signaling and activates expression of the K+ channel subunit Kcng4 to modulate delayed-rectifier currents. Dlk1 inactivation comprehensively shifts motor neurons toward slow biophysical and transcriptome signatures, while abolishing peak force outputs. Our findings provide insights into the development of motor neuron functional diversity and its contribution to the execution of movements. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1126/science.1246448 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 3 StartPage: 1264 Subjects: – SubjectFull: Motor neurons Type: general – SubjectFull: Ligands (Biochemistry) Type: general – SubjectFull: Muscle motility Type: general – SubjectFull: Notch protein genetics Type: general – SubjectFull: Animal mechanics Type: general Titles: – TitleFull: Dlk1 Promotes a Fast Motor Neuron Biophysical Signature Required for Peak Force Execution. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Müller, Daniel – PersonEntity: Name: NameFull: Cherukuri, Pitchaiah – PersonEntity: Name: NameFull: Henningfeld, Kristine – PersonEntity: Name: NameFull: Chor Hoon Poh – PersonEntity: Name: NameFull: Wittler, Lars – PersonEntity: Name: NameFull: Grote, Phillip – PersonEntity: Name: NameFull: Schlüter, Oliver – PersonEntity: Name: NameFull: Schmidt, Jennifer – PersonEntity: Name: NameFull: Laborda, Jorge – PersonEntity: Name: NameFull: Bauer, Steven R. – PersonEntity: Name: NameFull: Brownstone, Robert M. – PersonEntity: Name: NameFull: Marquardt, Till IsPartOfRelationships: – BibEntity: Dates: – D: 14 M: 03 Text: 3/14/2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 00368075 Numbering: – Type: volume Value: 343 – Type: issue Value: 6176 Titles: – TitleFull: Science (pre-March 2025) Type: main |
| ResultId | 1 |
