The influence of folate serum levels on depressive mood and mental processing in patients with epilepsy treated with enzyme-inducing anti-epileptic drugs.
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| Title: | The influence of folate serum levels on depressive mood and mental processing in patients with epilepsy treated with enzyme-inducing anti-epileptic drugs. |
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| Authors: | Rösche, J., Uhlmann, C., Weber, R., Fröscher, W. |
| Source: | Acta Neuropsychiatrica. Apr2003, Vol. 15 Issue 2, p63-67. 5p. |
| Subjects: | Serum, Mood (Psychology), Mental depression, Epilepsy, Drugs |
| Abstract: | Rösche J, Uhlmann C, Weber R, Fröscher W. The influence of folate serum levels on depressive mood and mental processing in patients with epilepsy treated with enzyme-inducing anti-epileptic drugs. Background: Folate deficiency is common in patients with epilepsy and also occurs in patients with depression or cognitive deficits. Objective: This study investigates whether low serum folate levels may contribute to depressive mood and difficulties in mental processing in patients with epilepsy treated with anti-epileptic drugs inducing the cytochrome P450. Methods: We analysed the serum folate levels, the score in the Self Rating Depression Scale (SDS) and the results of a bedside test in mental processing in 54 patients with epilepsy. Results: There was a significant negative correlation between the serum folate levels and the score in SDS and significant positive correlations between the score in SDS and the time needed to process an interference task or a letter-reading task. Conclusions: Low serum folate levels may contribute to depressive mood and therefore to difficulties in mental processing. Further studies utilizing total plasma homocysteine as a sensitive measure of functional folate deficiency and more elaborate tests of mental processing are required to elucidate the impact of folate metabolism on depressive mood and cognitive function in patients with epilepsy. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Neuropsychiatrica is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 9584851 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The influence of folate serum levels on depressive mood and mental processing in patients with epilepsy treated with enzyme-inducing anti-epileptic drugs. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Rösche%2C+J%2E%22">Rösche, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Uhlmann%2C+C%2E%22">Uhlmann, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Weber%2C+R%2E%22">Weber, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Fröscher%2C+W%2E%22">Fröscher, W.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Neuropsychiatrica%22">Acta Neuropsychiatrica</searchLink>. Apr2003, Vol. 15 Issue 2, p63-67. 5p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Serum%22">Serum</searchLink><br /><searchLink fieldCode="DE" term="%22Mood+%28Psychology%29%22">Mood (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Epilepsy%22">Epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rösche J, Uhlmann C, Weber R, Fröscher W. The influence of folate serum levels on depressive mood and mental processing in patients with epilepsy treated with enzyme-inducing anti-epileptic drugs. Background: Folate deficiency is common in patients with epilepsy and also occurs in patients with depression or cognitive deficits. Objective: This study investigates whether low serum folate levels may contribute to depressive mood and difficulties in mental processing in patients with epilepsy treated with anti-epileptic drugs inducing the cytochrome P450. Methods: We analysed the serum folate levels, the score in the Self Rating Depression Scale (SDS) and the results of a bedside test in mental processing in 54 patients with epilepsy. Results: There was a significant negative correlation between the serum folate levels and the score in SDS and significant positive correlations between the score in SDS and the time needed to process an interference task or a letter-reading task. Conclusions: Low serum folate levels may contribute to depressive mood and therefore to difficulties in mental processing. Further studies utilizing total plasma homocysteine as a sensitive measure of functional folate deficiency and more elaborate tests of mental processing are required to elucidate the impact of folate metabolism on depressive mood and cognitive function in patients with epilepsy. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Neuropsychiatrica is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1034/j.1601-5215.2003.00009.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 63 Subjects: – SubjectFull: Serum Type: general – SubjectFull: Mood (Psychology) Type: general – SubjectFull: Mental depression Type: general – SubjectFull: Epilepsy Type: general – SubjectFull: Drugs Type: general Titles: – TitleFull: The influence of folate serum levels on depressive mood and mental processing in patients with epilepsy treated with enzyme-inducing anti-epileptic drugs. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rösche, J. – PersonEntity: Name: NameFull: Uhlmann, C. – PersonEntity: Name: NameFull: Weber, R. – PersonEntity: Name: NameFull: Fröscher, W. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2003 Type: published Y: 2003 Identifiers: – Type: issn-print Value: 09242708 Numbering: – Type: volume Value: 15 – Type: issue Value: 2 Titles: – TitleFull: Acta Neuropsychiatrica Type: main |
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