Astrocyte pathology in the prefrontal cortex impairs the cognitive function of rats.
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| Title: | Astrocyte pathology in the prefrontal cortex impairs the cognitive function of rats. |
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| Authors: | Lima, A, Sardinha, V M, Oliveira, A F, Reis, M, Mota, C, Silva, M A, Marques, F, Cerqueira, J J, Pinto, L, Sousa, N, Oliveira, J F |
| Source: | Molecular Psychiatry. Jul2014, Vol. 19 Issue 7, p834-841. 8p. |
| Subjects: | Astrocytes, Prefrontal cortex, Neuroglia, Cognitive ability, Laboratory rats, Mental depression |
| Abstract: | Interest in astroglial cells is rising due to recent findings supporting dynamic neuron-astrocyte interactions. There is increasing evidence of astrocytic dysfunction in several brain disorders such as depression, schizophrenia or bipolar disorder; importantly these pathologies are characterized by the involvement of the prefrontal cortex and by significant cognitive impairments. Here, to model astrocyte pathology, we injected animals with the astrocyte specific toxin L-α-aminoadipate (L-AA) in the medial prefrontal cortex (mPFC); a behavioral and structural characterization two and six days after the injection was performed. Behavioral data shows that the astrocyte pathology in the mPFC affects the attentional set-shifting, the working memory and the reversal learning functions. Histological analysis of brain sections of the L-AA-injected animals revealed a pronounced loss of astrocytes in the targeted region. Interestingly, analysis of neurons in the lesion sites showed a progressive neuronal loss that was accompanied with dendritic atrophy in the surviving neurons. These results suggest that the L-AA-induced astrocytic loss in the mPFC triggers subsequent neuronal damage leading to cognitive impairment in tasks depending on the integrity of this brain region. These findings are of relevance to better understand the pathophysiological mechanisms underlying disorders that involve astrocytic loss/dysfunction in the PFC. [ABSTRACT FROM AUTHOR] |
| Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 96796141 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/mp.2013.182 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 834 Subjects: – SubjectFull: Astrocytes Type: general – SubjectFull: Prefrontal cortex Type: general – SubjectFull: Neuroglia Type: general – SubjectFull: Cognitive ability Type: general – SubjectFull: Laboratory rats Type: general – SubjectFull: Mental depression Type: general Titles: – TitleFull: Astrocyte pathology in the prefrontal cortex impairs the cognitive function of rats. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lima, A – PersonEntity: Name: NameFull: Sardinha, V M – PersonEntity: Name: NameFull: Oliveira, A F – PersonEntity: Name: NameFull: Reis, M – PersonEntity: Name: NameFull: Mota, C – PersonEntity: Name: NameFull: Silva, M A – PersonEntity: Name: NameFull: Marques, F – PersonEntity: Name: NameFull: Cerqueira, J J – PersonEntity: Name: NameFull: Pinto, L – PersonEntity: Name: NameFull: Sousa, N – PersonEntity: Name: NameFull: Oliveira, J F IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 13594184 Numbering: – Type: volume Value: 19 – Type: issue Value: 7 Titles: – TitleFull: Molecular Psychiatry Type: main |
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