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Vitamin D and cognitive function and dementia risk in a biracial cohort: the ARIC Brain MRI Study.

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Title: Vitamin D and cognitive function and dementia risk in a biracial cohort: the ARIC Brain MRI Study.
Authors: Schneider, A. L. C., Lutsey, P. L., Alonso, A., Gottesman, R. F., Sharrett, A. R., Carson, K. A., Gross, M., Post, W. S., Knopman, D. S., Mosley, T. H., Michos, E. D.
Source: European Journal of Neurology. Sep2014, Vol. 21 Issue 9, p1211-1211. 9p.
Subjects: Vitamin D, Cognitive ability, Dementia risk factors, Brain imaging, Magnetic resonance imaging, Cohort analysis, Atherosclerosis
Abstract: Background and purpose Some recent studies in older, largely white populations suggest that vitamin D, measured by 25-hydroxyvitamin D [25( OH)D], is important for cognition, but such results may be affected by reverse causation. Measuring 25( OH)D in late middle age before poor cognition affects behavior may provide clearer results. Methods This was a prospective cohort analysis of 1652 participants (52% white, 48% black) in the Atherosclerosis Risk in Communities ( ARIC) Brain MRI Study. 25( OH)D was measured from serum collected in 1993-1995. Cognition was measured by the delayed word recall test ( DWRT), the digit symbol substitution test ( DSST) and the word fluency test ( WFT). Dementia hospitalization was defined by ICD-9 codes. Adjusted linear, logistic and Cox proportional hazards models were used. Results Mean age of participants was 62 years and 60% were female. Mean 25( OH)D was higher in whites than blacks (25.5 vs. 17.3 ng/ml, P < 0.001). Lower 25( OH)D was not associated with lower baseline scores or with greater DWRT, DSST or WFT decline over a median of 3 or 10 years of follow-up ( P > 0.05). Over a median of 16.6 years, there were 145 incident hospitalized dementia cases. Although not statistically significant, lower levels of 25( OH)D were suggestive of an association with increased dementia risk [hazard ratio for lowest versus highest race-specific tertile: whites 1.32 (95% confidence interval 0.69, 2.55); blacks 1.53 (95% confidence interval 0.84, 2.79)]. Conclusions In contrast to prior studies performed in older white populations, our study of late middle age white and black participants did not find significant associations between lower levels of 25( OH)D with lower cognitive test scores at baseline, change in scores over time or dementia risk. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Vitamin D and cognitive function and dementia risk in a biracial cohort: the ARIC Brain MRI Study.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Schneider%2C+A%2E+L%2E+C%2E%22&quot;&gt;Schneider, A. L. C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lutsey%2C+P%2E+L%2E%22&quot;&gt;Lutsey, P. L.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Alonso%2C+A%2E%22&quot;&gt;Alonso, A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gottesman%2C+R%2E+F%2E%22&quot;&gt;Gottesman, R. F.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sharrett%2C+A%2E+R%2E%22&quot;&gt;Sharrett, A. R.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Carson%2C+K%2E+A%2E%22&quot;&gt;Carson, K. A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gross%2C+M%2E%22&quot;&gt;Gross, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Post%2C+W%2E+S%2E%22&quot;&gt;Post, W. S.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Knopman%2C+D%2E+S%2E%22&quot;&gt;Knopman, D. S.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mosley%2C+T%2E+H%2E%22&quot;&gt;Mosley, T. H.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Michos%2C+E%2E+D%2E%22&quot;&gt;Michos, E. D.&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Journal+of+Neurology%22&quot;&gt;European Journal of Neurology&lt;/searchLink&gt;. Sep2014, Vol. 21 Issue 9, p1211-1211. 9p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Vitamin+D%22&quot;&gt;Vitamin D&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cognitive+ability%22&quot;&gt;Cognitive ability&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Dementia+risk+factors%22&quot;&gt;Dementia risk factors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Brain+imaging%22&quot;&gt;Brain imaging&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Magnetic+resonance+imaging%22&quot;&gt;Magnetic resonance imaging&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cohort+analysis%22&quot;&gt;Cohort analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Atherosclerosis%22&quot;&gt;Atherosclerosis&lt;/searchLink&gt;
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  Data: Background and purpose Some recent studies in older, largely white populations suggest that vitamin D, measured by 25-hydroxyvitamin D [25( OH)D], is important for cognition, but such results may be affected by reverse causation. Measuring 25( OH)D in late middle age before poor cognition affects behavior may provide clearer results. Methods This was a prospective cohort analysis of 1652 participants (52% white, 48% black) in the Atherosclerosis Risk in Communities ( ARIC) Brain MRI Study. 25( OH)D was measured from serum collected in 1993-1995. Cognition was measured by the delayed word recall test ( DWRT), the digit symbol substitution test ( DSST) and the word fluency test ( WFT). Dementia hospitalization was defined by ICD-9 codes. Adjusted linear, logistic and Cox proportional hazards models were used. Results Mean age of participants was 62 years and 60% were female. Mean 25( OH)D was higher in whites than blacks (25.5 vs. 17.3 ng/ml, P &lt; 0.001). Lower 25( OH)D was not associated with lower baseline scores or with greater DWRT, DSST or WFT decline over a median of 3 or 10 years of follow-up ( P &gt; 0.05). Over a median of 16.6 years, there were 145 incident hospitalized dementia cases. Although not statistically significant, lower levels of 25( OH)D were suggestive of an association with increased dementia risk [hazard ratio for lowest versus highest race-specific tertile: whites 1.32 (95% confidence interval 0.69, 2.55); blacks 1.53 (95% confidence interval 0.84, 2.79)]. Conclusions In contrast to prior studies performed in older white populations, our study of late middle age white and black participants did not find significant associations between lower levels of 25( OH)D with lower cognitive test scores at baseline, change in scores over time or dementia risk. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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