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Statin Use and Pain in Older People with Cancer: A Cross-Sectional Study.

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Title: Statin Use and Pain in Older People with Cancer: A Cross-Sectional Study.
Authors: Turner, Justin P., Shakib, Sepehr, Singhal, Nimit, Hogan‐Doran, Jonathon, Prowse, Robert, Johns, Sally, Thynne, Tilenka, Bell, J. Simon
Source: Journal of the American Geriatrics Society. Oct2014, Vol. 62 Issue 10, p1900-1905. 6p. 3 Charts.
Subjects: Pain risk factors, Cancer patients, Cancer patient medical care, Chi-squared test, Confidence intervals, Logistic regression analysis, Statins (Cardiovascular agents), Visual analog scale, Cross-sectional method, Severity of illness index, Data analysis software, Descriptive statistics, Odds ratio, Mann Whitney U Test, Old age
Geographic Terms: South Australia
Abstract: Objectives To investigate statin use and pain in people with cancer aged 70 to 79 and 80 and older. Design Cross-sectional. Setting Medical oncology outpatient clinic at the Royal Adelaide Hospital. Participants Individuals aged 70 and older who presented consecutively between January 2009 and June 2010 (n = 385), of whom 106 were aged 80 and older. Measurements Participants completed a structured data collection instrument, documenting medication use, comorbidities and a general pain assessment (10-point visual analogue scale ( VAS)). Unadjusted and adjusted logistic regression was used to compute odds ratios ( ORs) and 95% confidence intervals ( CIs) for factors associated with statin use. Results The prevalence of statin use was 35% (n = 97) in people aged 70 to 79 and 39% (n = 41) in those aged 80 and older. After adjusting for age, sex, Charlson Comorbidity Index, and analgesic use, statin use was associated with self-reported pain ( VAS ≥5) ( OR = 4.09, 95% CI = 1.32-12.68) in people aged 80 and older but not in those aged 70 to 79. Half of participants using statins (51% n = 70) had a palliative treatment approach. Of the 41 statin users aged 80 and older, 20 (49%) were using statins for primary prevention. Conclusion The prevalence of statin use was similar in people aged 70 to 79 years and those aged 80 and older, with statin use associated with self-reported pain in people aged 80 and older. This highlights a potential benefit of 'deprescribing' statins in older people with cancer, especially those aged 80 and older. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Statin Use and Pain in Older People with Cancer: A Cross-Sectional Study.
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  Data: <searchLink fieldCode="AR" term="%22Turner%2C+Justin+P%2E%22">Turner, Justin P.</searchLink><br /><searchLink fieldCode="AR" term="%22Shakib%2C+Sepehr%22">Shakib, Sepehr</searchLink><br /><searchLink fieldCode="AR" term="%22Singhal%2C+Nimit%22">Singhal, Nimit</searchLink><br /><searchLink fieldCode="AR" term="%22Hogan‐Doran%2C+Jonathon%22">Hogan‐Doran, Jonathon</searchLink><br /><searchLink fieldCode="AR" term="%22Prowse%2C+Robert%22">Prowse, Robert</searchLink><br /><searchLink fieldCode="AR" term="%22Johns%2C+Sally%22">Johns, Sally</searchLink><br /><searchLink fieldCode="AR" term="%22Thynne%2C+Tilenka%22">Thynne, Tilenka</searchLink><br /><searchLink fieldCode="AR" term="%22Bell%2C+J%2E+Simon%22">Bell, J. Simon</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+the+American+Geriatrics+Society%22">Journal of the American Geriatrics Society</searchLink>. Oct2014, Vol. 62 Issue 10, p1900-1905. 6p. 3 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Pain+risk+factors%22">Pain risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+patients%22">Cancer patients</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+patient+medical+care%22">Cancer patient medical care</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Logistic+regression+analysis%22">Logistic regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Statins+%28Cardiovascular+agents%29%22">Statins (Cardiovascular agents)</searchLink><br /><searchLink fieldCode="DE" term="%22Visual+analog+scale%22">Visual analog scale</searchLink><br /><searchLink fieldCode="DE" term="%22Cross-sectional+method%22">Cross-sectional method</searchLink><br /><searchLink fieldCode="DE" term="%22Severity+of+illness+index%22">Severity of illness index</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Mann+Whitney+U+Test%22">Mann Whitney U Test</searchLink><br /><searchLink fieldCode="DE" term="%22Old+age%22">Old age</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22South+Australia%22">South Australia</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Objectives To investigate statin use and pain in people with cancer aged 70 to 79 and 80 and older. Design Cross-sectional. Setting Medical oncology outpatient clinic at the Royal Adelaide Hospital. Participants Individuals aged 70 and older who presented consecutively between January 2009 and June 2010 (n = 385), of whom 106 were aged 80 and older. Measurements Participants completed a structured data collection instrument, documenting medication use, comorbidities and a general pain assessment (10-point visual analogue scale ( VAS)). Unadjusted and adjusted logistic regression was used to compute odds ratios ( ORs) and 95% confidence intervals ( CIs) for factors associated with statin use. Results The prevalence of statin use was 35% (n = 97) in people aged 70 to 79 and 39% (n = 41) in those aged 80 and older. After adjusting for age, sex, Charlson Comorbidity Index, and analgesic use, statin use was associated with self-reported pain ( VAS ≥5) ( OR = 4.09, 95% CI = 1.32-12.68) in people aged 80 and older but not in those aged 70 to 79. Half of participants using statins (51% n = 70) had a palliative treatment approach. Of the 41 statin users aged 80 and older, 20 (49%) were using statins for primary prevention. Conclusion The prevalence of statin use was similar in people aged 70 to 79 years and those aged 80 and older, with statin use associated with self-reported pain in people aged 80 and older. This highlights a potential benefit of 'deprescribing' statins in older people with cancer, especially those aged 80 and older. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1111/jgs.13051
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      – Code: eng
        Text: English
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        PageCount: 6
        StartPage: 1900
    Subjects:
      – SubjectFull: Pain risk factors
        Type: general
      – SubjectFull: Cancer patients
        Type: general
      – SubjectFull: Cancer patient medical care
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      – SubjectFull: Chi-squared test
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      – SubjectFull: Confidence intervals
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      – SubjectFull: Logistic regression analysis
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      – SubjectFull: Statins (Cardiovascular agents)
        Type: general
      – SubjectFull: Visual analog scale
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      – SubjectFull: Cross-sectional method
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      – SubjectFull: Severity of illness index
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Odds ratio
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      – SubjectFull: Mann Whitney U Test
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      – SubjectFull: Old age
        Type: general
      – SubjectFull: South Australia
        Type: general
    Titles:
      – TitleFull: Statin Use and Pain in Older People with Cancer: A Cross-Sectional Study.
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              Text: Oct2014
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