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The highly efficacious actions ofN-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine’s actions?

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Title: The highly efficacious actions ofN-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine’s actions?
Authors: Davies, Marilyn A.1, Compton-Toth, Beth Ann2, Hufeisen, Sandra J.2, Meltzer, Herbert Y.3,4, Roth, Bryan L.1,2,5,6 bryan.roth@case.edu
Source: Psychopharmacology. Apr2005, Vol. 178 Issue 4, p451-460.
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  Data: The highly efficacious actions ofN-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M<subscript>1</subscript> agonism a pre-requisite for mimicking clozapine’s actions?
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  Data: <searchLink fieldCode="AR" term="%22Davies%2C+Marilyn+A%2E%22">Davies, Marilyn A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Compton-Toth%2C+Beth+Ann%22">Compton-Toth, Beth Ann</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Hufeisen%2C+Sandra+J%2E%22">Hufeisen, Sandra J.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Meltzer%2C+Herbert+Y%2E%22">Meltzer, Herbert Y.</searchLink><relatesTo>3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Roth%2C+Bryan+L%2E%22">Roth, Bryan L.</searchLink><relatesTo>1,2,5,6</relatesTo><i> bryan.roth@case.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Apr2005, Vol. 178 Issue 4, p451-460.
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        Value: 10.1007/s00213-004-2017-1
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      – TitleFull: The highly efficacious actions ofN-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine’s actions?
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              Text: Apr2005
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