Fulcrum Occupancy–Leverage Perturbation Strategy Enables Rapid Discovery of Potent CDK2–Cyclin A2 Interaction Inhibitors.
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| Title: | Fulcrum Occupancy–Leverage Perturbation Strategy Enables Rapid Discovery of Potent CDK2–Cyclin A2 Interaction Inhibitors. |
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| Authors: | Sun, Ge1,2, Chi, Shuaishuai1,3, Li, Jiacheng1,2, Xu, Pan1,2, Lin, Tingting2, Chen, Chao1,4, Liu, Liping1,2, Yang, Yulin1,2, Yan, Ruyu1,2,5, Han, HongBo1,2, Wang, Mingyu1,2, Fu, Shuiping1,2, Qiu, Junyi6, Wang, Mingchen5, Wei, Fan2,7, Yang, Yaxi1,2,4,5, Zheng, Jie1, Chen, Kaixian1,2, Chen, Shijie1,8, sjchen@pharm.ecnu.edu.cn, Chen, Yi4,7, ychen@simm.ac.cn |
| Source: | Angewandte Chemie; 10/6/2025, Vol. 137 Issue 41, p1-14, 14p |
| Database: | Applied Science & Technology Source |
| ISSN: | 00448249 |
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| DOI: | 10.1002/ange.202513542 |
