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Pyrotinib inhibits the tumorigenicity of HER2-positive non-small cell lung cancer by inducing ARIH1/ubiquitin/lysosome-dependent degradation of HER2.

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Title: Pyrotinib inhibits the tumorigenicity of HER2-positive non-small cell lung cancer by inducing ARIH1/ubiquitin/lysosome-dependent degradation of HER2.
Authors: Li, Xiyue1,2,3,4 (AUTHOR), Wang, Jiehong1,2,4 (AUTHOR), Li, Shu1,2,4 (AUTHOR), Fang, Jing1,4 (AUTHOR), Hao, Yue5 (AUTHOR), Xu, Chunwei6 (AUTHOR), Shu, You7 (AUTHOR), Shu, Hong7 (AUTHOR), Chen, Jiaojiao2,4 (AUTHOR), Lu, Naiyan8 (AUTHOR), Zhu, Xue1,4 (AUTHOR) zhuxue@jsinm.org, Wang, Ke1,4 (AUTHOR) wangke@jsinm.org, Wang, Xun2,3 (AUTHOR) 081104125@fudan.edu.cn
Source: Cellular Oncology (2211-3428). Dec2025, Vol. 48 Issue 6, p1795-1808. 14p.
Database: Academic Search Ultimate
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ISSN:22113428
DOI:10.1007/s13402-025-01107-z